CIP1_KIP1*

Protein CIP1_KIP1* map

Identifiers
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
HUGO:CDKN1C HGNC:1786 ENTREZ:1028 UNIPROT:P49918 GENECARDS:CDKN1C KEGG:1028 ATLASONC:GC_CDKN1C WIKI:CDKN1C

Maps_Modules
 DNA repair  map  / G1_CC_PHASE  map
 DNA repair  map  / S_CC_PHASE  map

References
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786

CIP1_KIP1*@default

References
d_re345:( DNA repair  map ) CHECKPOINT is p53_dependent_G1_S_checkpoint
d_re115( DNA repair  map ):
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
d_re120( DNA repair  map ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141


Modifications:
In compartment: default
  1. CIP1_KIP1*@default map

Participates in complexes:
In compartment: default

  1. CIP1_KIP1*:​PARP1@default map

  2. CDK2:​CIP1_KIP1*:​CyclinE*@default map
  3. CDK2:​CIP1_KIP1*:​CyclinA1*@default map
  4. (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@default map

Participates in reactions:
As Reactant or Product:

  1. (CDK4_6*|​T172_pho:​CyclinD*)|​active@default map + CIP1_KIP1*@default map map (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@default map

  2. CIP1_KIP1*@default map + CDK2:​CyclinE*@default map map CDK2:​CIP1_KIP1*:​CyclinE*@default map
  3. CIP1_KIP1*@default map + CDK2:​CyclinA1*@default map map CDK2:​CIP1_KIP1*:​CyclinA1*@default map
  4. (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@default map map CIP1_KIP1*@default map + (CDK4_6*|​T172_pho:​CyclinD*)|​active@default map
  5. CDK2:​CIP1_KIP1*:​CyclinE*@default map map CDK2:​CyclinE*@default map + CIP1_KIP1*@default map
  6. CDK2:​CIP1_KIP1*:​CyclinA1*@default map map CDK2:​CyclinA1*@default map + CIP1_KIP1*@default map
  7. CIP1_KIP1*@default map map degraded
  8. rCIP/KIP*@default map map CIP1_KIP1*@default map
  9. CIP1_KIP1*@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map map CIP1_KIP1*:​PARP1@default map

As Catalyser:

  1. G1 phase@default map map S phase@default map

  2. G2 phase@default map map M phase@default map
  3. E2F1:​RB1@default map map E2F1:​RB1|​pho@default map
  4. E2F4_5*:​p107*@default map map E2F4_5*:​p107*|​pho@default map

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