CHEK2

Protein CHEK2 map

Identifiers
CHK2 checkpoint homolog (S. pombe)
HUGO:CHEK2 HGNC:16627 ENTREZ:11200 UNIPROT:O96017 GENECARDS:CHEK2 REACTOME:87288 KEGG:11200 ATLASONC:CHEK2ID312 WIKI:CHEK2
Q9UGF0

Maps_Modules
 DNA repair  map  / G1_S_CHECKPOINT  map
 DNA repair  map  / S_PHASE_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 Cell cycle  map  / E2F1  map
 Cell cycle  map  / APOPTOSIS_ENTRY  map
 Cell cycle  map  / CDC25  map

References
PMID:15459660, PMID:15810020, PMID:18566216, PMID:17464182

CHEK2|​pho|​active@default

References
d_re34:( DNA repair  map ) PMID:19788416
d_re65( DNA repair  map ):
Phosphorylation of CDC25A, B or C by CHEK1 and CHEK2 inactivates CDC25, prevents activating de-phosphorylation of CDKs by CDC25 A, B, C
and stops cell cycle propagation
kegg cell cycle
PMID:20126263, PMID:17568790
d_re70:( DNA repair  map ) PMID:18971944
d_re71( DNA repair  map ):
For inactivation of EXO1 by 53BP1-mediated phosphorylation:
PMID:18756267, PMID:15867354
ATM and ATR phosphorylate EXO1 and lead to EXO1 ubiquitination and degradation:
PMID:18048416, PMID:11438669, PMID:20019063
d_re188( DNA repair  map ):
PMID:18931676, PMID:19686080, PMID:17296736
Link between cell cycle and activation of Fanconi pathway

CHEK2|​Thr68_pho@Nucleus

References
c_re130( Cell cycle  map ):
Phosphorylation initiated by E2F1.
PMID:15024084
E2F1 stimulates ATM to phosphorylate p53 (and Chk2)
PMID:15140942, PMID:12773400, PMID:10973490
c_re132( Cell cycle  map ):
ATM phosphorylates p53 in case of DNA double-strand breaks. ATR phosphorylates p53 in case of other types of DNA damages.
PMID:15140942
PMID:15140942, PMID:9843217, PMID:9733515, PMID:9733514
c_re135:( Cell cycle  map ) PMID:15024084, PMID:15140942
c_re265( Cell cycle  map ):
Inactivated by phosphorylation by CHEK1 and CHEK2
PMID:12478465, PMID:12814430, PMID:9278512, PMID:9836640, PMID:9889122
Phosphorylation by CYCLINB-CDC2
PMID:11313986
c_re621( Cell cycle  map ):
Protein stabilized by phosphorylation.
PMID:15838517, PMID:15140942

CHEK2@Nucleus

References
c_re130( Cell cycle  map ):
Phosphorylation initiated by E2F1.
PMID:15024084
E2F1 stimulates ATM to phosphorylate p53 (and Chk2)
PMID:15140942, PMID:12773400, PMID:10973490
c_re621( Cell cycle  map ):
Protein stabilized by phosphorylation.
PMID:15838517, PMID:15140942


Modifications:
In compartment: Nucleus
  1. CHEK2@Nucleus map

  2. CHEK2|​Thr68_pho@Nucleus map

In compartment: default

  1. CHEK2@default map

  2. CHEK2|​pho|​active@default map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. CHEK2@Nucleus map map CHEK2|​Thr68_pho@Nucleus map

    2. CHEK2@default map map CHEK2|​pho|​active@default map

    As Catalyser:

    1. p53*@Nucleus map map p53*|​Ser15_pho@Nucleus map

    2. p53*|​Ser15_pho@Nucleus map map p53*|​Ser15_pho|​Ser20_pho@Nucleus map
    3. CDC25C|​pho@Nucleus map map CDC25C|​Ser216_pho|​pho@Nucleus map
    4. DP1*:​E2F1|​Lys_ace:​PCAF*@Nucleus map map PCAF*@Nucleus map + DP1*:​E2F1|​Lys_ace|​Ser364_pho@Nucleus map
    5. FANCE@default map map FANCE|​S376_pho|​T346_pho@default map
    6. CDC25C@default map map CDC25C|​S216_pho@default map
    7. p53*@default map map p53*|​pho|​ace|​active@default map
    8. BRCA1@default map map BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map
    9. CDC25A@default map map CDC25A|​S76_pho|​S178_pho|​S124_pho|​S279_pho|​S293_pho@default map
    10. CDC25B@default map map CDC25B|​S230_pho|​S151_pho|​S323_pho@default map
    11. XRCC1@default map map XRCC1|​pho@default map
    12. EXO1@default map map EXO1|​S692_pho|​S372_pho|​S567_pho|​S587_pho@default map

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