CHEK1

Protein CHEK1 map

Identifiers
CHK1 checkpoint homolog (S. pombe)
HUGO:CHEK1 HGNC:1925 ENTREZ:1111 UNIPROT:O14757 GENECARDS:CHEK1 REACTOME:87284 KEGG:1111 ATLASONC:GC_CHEK1 WIKI:CHEK1

Maps_Modules
 DNA repair  map  / G1_S_CHECKPOINT  map
 DNA repair  map  / S_PHASE_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 Cell cycle  map  / APOPTOSIS_ENTRY  map
 Cell cycle  map  / WEE  map

References
For S-phase checkpoint
PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197

CHEK1@Nucleus

References
d_re33:( DNA repair  map ) PMID:15485915

CHEK1|​pho|​active@Nucleus

References
d_re33:( DNA repair  map ) PMID:15485915
d_re34:( DNA repair  map ) PMID:19788416
d_re65( DNA repair  map ):
Phosphorylation of CDC25A, B or C by CHEK1 and CHEK2 inactivates CDC25, prevents activating de-phosphorylation of CDKs by CDC25 A, B, C
and stops cell cycle propagation
kegg cell cycle
PMID:20126263, PMID:17568790
d_re82:( DNA repair  map ) PMID:21376743
d_re160( DNA repair  map ):
PMID:18931676
PMID:19686080
Link between cell cycle and activation of Fanconi pathway
d_re186( DNA repair  map ):
PMID:18931676, PMID:19686080
d_re187( DNA repair  map ):
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723
d_re188( DNA repair  map ):
PMID:18931676, PMID:19686080, PMID:17296736
d_re463( DNA repair  map ):
Arrests cell cycle in S-phase in response to stalled replication fork or ds breaks in DNA:
PMID:15459660, PMID:17384638, PMID:19793801

CHEK1|​S317_pho|​S345_pho@Nucleus

References
c_re142( Cell cycle  map ):
PMID:15024084
Phosphorylation by ATR at Ser-317 et Ser-345
PMID:15190204, PMID:10859163, PMID:11090622, PMID:11390642, PMID:15279789, PMID:12781359, PMID:15272308, PMID:12766152, PMID:16431910, PMID:10859164, PMID:16360315
c_re135:( Cell cycle  map ) PMID:15024084, PMID:15140942
c_re195( Cell cycle  map ):
phosphorylation and inactivation of Wee1 kinase
PMID:8515817, PMID:15070733, PMID:7681363 (yeast)
Cyclin B phosphorylates Myt1 in vitro
PMID:9268380
c_re265( Cell cycle  map ):
Inactivated by phosphorylation by CHEK1 and CHEK2
PMID:12478465, PMID:12814430, PMID:9278512, PMID:9836640, PMID:9889122
Phosphorylation by CYCLINB-CDC2
PMID:11313986

CHEK1@Nucleus

References
c_re142( Cell cycle  map ):
PMID:15024084
Phosphorylation by ATR at Ser-317 et Ser-345
PMID:15190204, PMID:10859163, PMID:11090622, PMID:11390642, PMID:15279789, PMID:12781359, PMID:15272308, PMID:12766152, PMID:16431910, PMID:10859164, PMID:16360315


Modifications:
In compartment: Nucleus
  1. CHEK1@Nucleus map

  2. CHEK1@Nucleus map
  3. CHEK1|​pho|​active@Nucleus map
  4. CHEK1|​S317_pho|​S345_pho@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@Nucleus map

  2. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@Nucleus map
  3. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3:​TIM1*:​TIPIN@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. CHEK1@Nucleus map map CHEK1|​S317_pho|​S345_pho@Nucleus map

  2. CHEK1@Nucleus map map CHEK1|​pho|​active@Nucleus map
  3. HCLK2*@Nucleus map + CLSPN|​pho@Nucleus map + ATRIP:​ATR|​pho@Nucleus map + CHEK1|​pho|​active@Nucleus map map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@Nucleus map
  4. TIM1*@Nucleus map + CLSPN|​pho@Nucleus map + PCNA|​K164_ubi@Nucleus map + ATRIP:​ATR|​pho@Nucleus map map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@Nucleus map
  5. ATRIP:​ATR|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3@Nucleus map + TIPIN@Nucleus map + TIM1*@Nucleus map + CHEK1|​pho|​active@Nucleus map map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3:​TIM1*:​TIPIN@Nucleus map
  6. rCHEK1@Nucleus map map CHEK1@Nucleus map

As Catalyser:

  1. p53*|​Ser15_pho@Nucleus map map p53*|​Ser15_pho|​Ser20_pho@Nucleus map

  2. WEE1@Nucleus map map WEE1|​pho@Nucleus map
  3. CDC25C|​pho@Nucleus map map CDC25C|​Ser216_pho|​pho@Nucleus map
  4. S phase@Nucleus map map G2 phase@Nucleus map
  5. FANCI@Nucleus map map FANCI|​pho@Nucleus map
  6. gDamaged DNA*@Nucleus map map gRepaired_DNA*@Nucleus map
  7. FANCA@Nucleus map map FANCA|​pho@Nucleus map
  8. FANCD2@Nucleus map map FANCD2|​pho@Nucleus map
  9. FANCE@Nucleus map map FANCE|​S376_pho|​T346_pho@Nucleus map
  10. FANCG@Nucleus map map FANCG|​S7_pho@Nucleus map
  11. CDC25C@Nucleus map map CDC25C|​S216_pho@Nucleus map
  12. p53*@Nucleus map map p53*|​pho|​ace|​active@Nucleus map
  13. ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@Nucleus map + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@Nucleus map + CDT1@Nucleus map + CDC6@Nucleus map + CDC45@Nucleus map + POLA*@Nucleus map + PRIM*@Nucleus map map CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*:​RPA1:​RPA2:​RPA3@Nucleus map
  14. No DNA replicarion@Nucleus map map DNA replicarion@Nucleus map
  15. CDC25A@Nucleus map map CDC25A|​S76_pho|​S178_pho|​S124_pho|​S279_pho|​S293_pho@Nucleus map
  16. CDC25B@Nucleus map map CDC25B|​S230_pho|​S151_pho|​S323_pho@Nucleus map
  17. DNA-PK*@Nucleus map map DNA-PK*|​pho@Nucleus map

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