CFL1

Protein CFL1 map

Identifiers
cofilin 1
HUGO:CFL1 HGNC:1874 ENTREZ:1072 UNIPROT:P23528 GENECARDS:CFL1 REACTOME:52508 KEGG:6944 ATLASONC:GC_CFL1 WIKI:CFL1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:15866889
Cofilin is required for the maintenance of a polarized cytoskeleton and thus for directional cell miogration.

CFL1@Cytoplasm

References
e_re471( EMT  map ):
PMID:22154077, PMID:17522712
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
PMID:15866889
The ARP2_3 complex and Cofilin are involved in protrusion at the leading edge: the actin-severing activity of cofilin and the actin-branching activity of Arp2_3 act in synergy to drive the extension of lamellipodia.
Cofilin is also required for the maintenance of a polarized cytoskeleton and thus for directional cell migration.
Integrins control motile strategy through a Rho-cofilin pathway.
Adhesion to fibronectin by a5b1 integrin leads to phosphorylation and thus inactivation of cofilin.
Cells thus fail to polarize their cytoskeleton but extend thin protrusion with cell-matrix adhesions in multiple directions.

CFL1|​pho@Cytoplasm

References
e_re471( EMT  map ):
PMID:22154077, PMID:17522712
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
PMID:15866889
The ARP2_3 complex and Cofilin are involved in protrusion at the leading edge: the actin-severing activity of cofilin and the actin-branching activity of Arp2_3 act in synergy to drive the extension of lamellipodia.
Cofilin is also required for the maintenance of a polarized cytoskeleton and thus for directional cell migration.
Integrins control motile strategy through a Rho-cofilin pathway.
Adhesion to fibronectin by a5b1 integrin leads to phosphorylation and thus inactivation of cofilin.
Cells thus fail to polarize their cytoskeleton but extend thin protrusion with cell-matrix adhesions in multiple directions.


Modifications:
In compartment: Cytoplasm
  1. CFL1@Cytoplasm map

  2. CFL1|​pho@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. Actin cytoskeletal*:​CFL1@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. CFL1@Cytoplasm map map CFL1|​pho@Cytoplasm map

  2. CFL1@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​CFL1@Cytoplasm map
  3. Actin cytoskeletal*:​CFL1@Cytoplasm map map Actin polymerization@Nucleus map

As Catalyser:

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