During EMT, tightly zipped and largely immobile epithelial cells transform into highly mobile mesenchymal cells. The process requires disruption of cell-cell adhesions (PMID: 18050482), including tight junctions (PMID: 17950242, PMID: 17945185, PMID: 15151915), adherens junctions (PMID: 22770731, PMID: 20066120, PMID: 16325582), desmosomes (PMID: 19955337) and gap junctions (PMID: 20066080, PMID: 14576341, PMID: 22935924).
======== References ========
PMID:1720120 Kuhn TB, Stoeckli ET, Condrau MA, Rathjen FG, Sonderegger P (1991) Neurite outgrowth on immobilized axonin-1 is mediated by a heterophilic interaction with L1(G4). J. Cell Biol. 115(4);1113-26.
PMID:2288140 Orth K, Haas S, Oettinger W, Beger HG (1990) [Risk in elective cholecystectomy]. Z Gastroenterol 28(11);616-20.
PMID:2344615 Tepass U, Theres C, Knust E (1990) crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell 61(5);787-99.
PMID:6368220 Rathjen FG, Schachner M (1984) Immunocytological and biochemical characterization of a new neuronal cell surface component (L1 antigen) which is involved in cell adhesion. EMBO J. 3(1);1-10.
PMID:7479768 Chuang TH, Xu X, Kaartinen V, Heisterkamp N, Groffen J, Bokoch GM (1995) Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc. Natl. Acad. Sci. U.S.A. 92(22);10282-6.
PMID:7479854 Nusrat A, Giry M, Turner JR, Colgan SP, Parkos CA, Carnes D, Lemichez E, Boquet P, Madara JL (1995) Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia. Proc. Natl. Acad. Sci. U.S.A. 92(23);10629-33.
PMID:7512751 Brooks PC, Clark RA, Cheresh DA (1994) Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 264(5158);569-71.
PMID:7529872 Bergman M, Joukov V, Virtanen I, Alitalo K (1995) Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading. Mol. Cell. Biol. 15(2);711-22.
PMID:7542250 Kinch MS, Clark GJ, Der CJ, Burridge K (1995) Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. J. Cell Biol. 130(2);461-71.
PMID:7613634 Kadmon G, von Bohlen und Halbach F, Horstkorte R, Eckert M, Altevogt P, Schachner M (1995) Evidence for cis interaction and cooperative signalling by the heat-stable antigen nectadrin (murine CD24) and the cell adhesion molecule L1 in neurons. Eur. J. Neurosci. 7(5);993-1004.
PMID:7657702 Schaller MD, Otey CA, Hildebrand JD, Parsons JT (1995) Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J. Cell Biol. 130(5);1181-7.
PMID:7673236 Jullien-Flores V, Dorseuil O, Romero F, Letourneur F, Saragosti S, Berger R, Tavitian A, Gacon G, Camonis JH (1995) Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. J. Biol. Chem. 270(38);22473-7.
PMID:7962210 Tanihara H, Kido M, Obata S, Heimark RL, Davidson M, St John T, Suzuki S (1994) Characterization of cadherin-4 and cadherin-5 reveals new aspects of cadherins. J. Cell. Sci. 107 ( Pt 6);1697-704.
PMID:8188753 White TW, Bruzzone R, Wolfram S, Paul DL, Goodenough DA (1994) Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins. J. Cell Biol. 125(4);879-92.
PMID:8207064 Takeuchi K, Sato N, Kasahara H, Funayama N, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S (1994) Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J. Cell Biol. 125(6);1371-84.
PMID:8262969 Tan EC, Leung T, Manser E, Lim L (1993) The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins. J. Biol. Chem. 268(36);27291-8.
PMID:8365569 Tepass U, Knust E (1993) Crumbs and stardust act in a genetic pathway that controls the organization of epithelia in Drosophila melanogaster. Dev. Biol. 159(1);311-26.
PMID:8522586 Berryman M, Gary R, Bretscher A (1995) Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis. J. Cell Biol. 131(5);1231-42.
PMID:8524413 Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378(6559);785-9.
PMID:8537347 Burbelo PD, Miyamoto S, Utani A, Brill S, Yamada KM, Hall A, Yamada Y (1995) p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. J. Biol. Chem. 270(52);30919-26.
PMID:8571126 Watanabe G, Saito Y, Madaule P, Ishizaki T, Fujisawa K, Morii N, Mukai H, Ono Y, Kakizuka A, Narumiya S (1996) Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science 271(5249);645-8.
PMID:8625410 Symons M, Derry JM, Karlak B, Jiang S, Lemahieu V, Mccormick F, Francke U, Abo A (1996) Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 84(5);723-34.
PMID:8636223 Montgomery AM, Becker JC, Siu CH, Lemmon VP, Cheresh DA, Pancook JD, Zhao X, Reisfeld RA (1996) Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3. J. Cell Biol. 132(3);475-85.
PMID:8638126 Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P (1996) Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272(5264);1023-6.
PMID:8662891 Reid T, Furuyashiki T, Ishizaki T, Watanabe G, Watanabe N, Fujisawa K, Morii N, Madaule P, Narumiya S (1996) Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J. Biol. Chem. 271(23);13556-60.
PMID:8666229 Yost C, Torres M, Miller JR, Huang E, Kimelman D, Moon RT (1996) The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev. 10(12);1443-54.
PMID:8755653 Str–mblad S, Becker JC, Yebra M, Brooks PC, Cheresh DA (1996) Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis. J. Clin. Invest. 98(2);426-33.
PMID:8805275 Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J (1996) Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr. Biol. 6(5);598-605.
PMID:8893017 Hortsch M (1996) The L1 family of neural cell adhesion molecules: old proteins performing new tricks. Neuron 17(4);587-93.
PMID:8898967 Ebeling O, Duczmal A, Aigner S, Geiger C, Sch–llhammer S, Kemshead JT, M–ller P, Schwartz-Albiez R, Altevogt P (1996) L1 adhesion molecule on human lymphocytes and monocytes: expression and involvement in binding to alpha v beta 3 integrin. Eur. J. Immunol. 26(10);2508-16.
PMID:8910277 Joneson T, McDonough M, Bar-Sagi D, Van Aelst L (1996) RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science 274(5291);1374-6.
PMID:8910292 Teramoto H, Coso OA, Miyata H, Igishi T, Miki T, Gutkind JS (1996) Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. J. Biol. Chem. 271(44);27225-8.
PMID:8939998 Zalcman G, Closson V, Camonis J, Honor– N, Rousseau-Merck MF, Tavitian A, Olofsson B (1996) RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. J. Biol. Chem. 271(48);30366-74.
PMID:9003039 Hall H, Carbonetto S, Schachner M (1997) L1/HNK-1 carbohydrate- and beta 1 integrin-dependent neural cell adhesion to laminin-1. J. Neurochem. 68(2);544-53.
PMID:9069260 Morrison DK, Cutler RE (1997) The complexity of Raf-1 regulation. Curr. Opin. Cell Biol. 9(2);174-9.
PMID:9113980 Adra CN, Manor D, Ko JL, Zhu S, Horiuchi T, Van Aelst L, Cerione RA, Lim B (1997) RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. Proc. Natl. Acad. Sci. U.S.A. 94(9);4279-84.
PMID:9127006 Pancook JD, Reisfeld RA, Varki N, Vitiello A, Fox RI, Montgomery AM (1997) Expression and regulation of the neural cell adhesion molecule L1 on human cells of myelomonocytic and lymphoid origin. J. Immunol. 158(9);4413-21.
PMID:9157999 Chen Z, Fisher RJ, Riggs CW, Rhim JS, Lautenberger JA (1997) Inhibition of vascular endothelial growth factor-induced endothelial cell migration by ETS1 antisense oligonucleotides. Cancer Res. 57(10);2013-9.
PMID:9278444 Kanemitsu MY, Loo LW, Simon S, Lau AF, Eckhart W (1997) Tyrosine phosphorylation of connexin 43 by v-Src is mediated by SH2 and SH3 domain interactions. J. Biol. Chem. 272(36);22824-31.
PMID:9287351 Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S, Takai Y (1997) Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein. J. Biol. Chem. 272(37);23371-5.
PMID:9312003 D’Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (1997) A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. EMBO J. 16(17);5445-54.
PMID:9334353 Mandai K, Nakanishi H, Satoh A, Obaishi H, Wada M, Nishioka H, Itoh M, Mizoguchi A, Aoki T, Fujimoto T, Matsuda Y, Tsukita S, Takai Y (1997) Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J. Cell Biol. 139(2);517-28.
PMID:9362522 Takaishi K, Sasaki T, Kotani H, Nishioka H, Takai Y (1997) Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J. Cell Biol. 139(4);1047-59.
PMID:9389648 Liu F, Pouponnot C, Massagu– J (1998) Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11(23);3157-67.
PMID:9427749 Nagata Ki, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (1998) The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO J. 17(1);149-58.
PMID:9490022 Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P (1998) Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity. FEBS Lett. 422(2);269-73.
PMID:9592087 Ressot C, Gom–s D, Dautigny A, Pham-Dinh D, Bruzzone R (1998) Connexin32 mutations associated with X-linked Charcot-Marie-Tooth disease show two distinct behaviors: loss of function and altered gating properties. J. Neurosci. 18(11);4063-75.
PMID:9618481 Moustakas A, Kardassis D (1998) Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc. Natl. Acad. Sci. U.S.A. 95(12);6733-8.
PMID:9641915 Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG, Bollag G, Sternweis PC (1998) p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science 280(5372);2109-11.
PMID:9660866 Jou TS, Schneeberger EE, Nelson WJ (1998) Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J. Cell Biol. 142(1);101-15.
PMID:9670020 Kawabata M, Inoue H, Hanyu A, Imamura T, Miyazono K (1998) Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors. EMBO J. 17(14);4056-65.
PMID:9739078 Kowalczyk AP, Navarro P, Dejana E, Bornslaeger EA, Green KJ, Kopp DS, Borgwardt JE (1998) VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions. J. Cell. Sci. 111 ( Pt 20);3045-57.
PMID:9744077 Knaus UG, Bokoch GM (1998) The p21Rac/Cdc42-activated kinases (PAKs). Int. J. Biochem. Cell Biol. 30(8);857-62.
PMID:9753323 Kaech SM, Whitfield CW, Kim SK (1998) The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell 94(6);761-71.
PMID:9753324 Butz S, Okamoto M, S–dhof TC (1998) A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Cell 94(6);773-82.
PMID:9789025 Mao J, Yuan H, Xie W, Wu D (1998) Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13. Proc. Natl. Acad. Sci. U.S.A. 95(22);12973-6.
PMID:9808620 Kiyokawa E, Hashimoto Y, Kobayashi S, Sugimura H, Kurata T, Matsuda M (1998) Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev. 12(21);3331-6.
PMID:9819392 Roof RW, Haskell MD, Dukes BD, Sherman N, Kinter M, Parsons SJ (1998) Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formation. Mol. Cell. Biol. 18(12);7052-63.
PMID:9822605 Schuebel KE, Movilla N, Rosa JL, Bustelo XR (1998) Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2. EMBO J. 17(22);6608-21.
PMID:9822620 Borg JP, Straight SW, Kaech SM, de Tadd–o-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B (1998) Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. J. Biol. Chem. 273(48);31633-6.
PMID:9832503 Diehl JA, Cheng M, Roussel MF, Sherr CJ (1998) Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 12(22);3499-511.
PMID:9843499 Miki H, Suetsugu S, Takenawa T (1998) WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. EMBO J. 17(23);6932-41.
PMID:9857026 Ren Y, Li R, Zheng Y, Busch H (1998) Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. J. Biol. Chem. 273(52);34954-60.
PMID:9864376 Debiec H, Christensen EI, Ronco PM (1998) The cell adhesion molecule L1 is developmentally regulated in the renal epithelium and is involved in kidney branching morphogenesis. J. Cell Biol. 143(7);2067-79.
PMID:10022831 Soldi R, Mitola S, Strasly M, Defilippi P, Tarone G, Bussolino F (1999) Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J. 18(4);882-92.
PMID:10023776 Ishiai M, Kurosaki M, Pappu R, Okawa K, Ronko I, Fu C, Shibata M, Iwamatsu A, Chan AC, Kurosaki T (1999) BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells. Immunity 10(1);117-25.
PMID:10047517 Bretscher A (1999) Regulation of cortical structure by the ezrin-radixin-moesin protein family. Curr. Opin. Cell Biol. 11(1);109-16.
PMID:10048576 Oda N, Abe M, Sato Y (1999) ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin beta3. J. Cell. Physiol. 178(2);121-32.
PMID:10102271 Bhat MA, Izaddoost S, Lu Y, Cho KO, Choi KW, Bellen HJ (1999) Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Cell 96(6);833-45.
PMID:10201372 Tetsu O, McCormick F (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398(6726);422-6.
PMID:10318916 Shtutman M, Zhurinsky J, Simcha I, Albanese C, D’Amico M, Pestell R, Ben-Ze’ev A (1999) The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. U.S.A. 96(10);5522-7.
PMID:10413675 Beer S, Oleszewski M, Gutwein P, Geiger C, Altevogt P (1999) Metalloproteinase-mediated release of the ectodomain of L1 adhesion molecule. J. Cell. Sci. 112 ( Pt 16);2667-75.
PMID:10421629 Willert K, Shibamoto S, Nusse R (1999) Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. Genes Dev. 13(14);1768-73.
PMID:10428961 Li L, Yuan H, Weaver CD, Mao J, Farr GH, Sussman DJ, Jonkers J, Kimelman D, Wu D (1999) Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J. 18(15);4233-40.
PMID:10455125 Oleszewski M, Beer S, Katich S, Geiger C, Zeller Y, Rauch U, Altevogt P (1999) Integrin and neurocan binding to L1 involves distinct Ig domains. J. Biol. Chem. 274(35);24602-10.
PMID:10461188 Bagrodia S, Cerione RA (1999) Pak to the future. Trends Cell Biol. 9(9);350-5.
PMID:10467124 Carlier MF, Ducruix A, Pantaloni D (1999) Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection. Chem. Biol. 6(9);R235-40.
PMID:10469653 De Angelis E, MacFarlane J, Du JS, Yeo G, Hicks R, Rathjen FG, Kenwrick S, Br–mmendorf T (1999) Pathological missense mutations of neural cell adhesion molecule L1 affect homophilic and heterophilic binding activities. EMBO J. 18(17);4744-53.
PMID:10490598 Joberty G, Perlungher RR, Macara IG (1999) The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol. Cell. Biol. 19(10);6585-97.
PMID:10511705 Welch MD (1999) The world according to Arp: regulation of actin nucleation by the Arp2/3 complex. Trends Cell Biol. 9(11);423-7.
PMID:10545505 Carragher NO, Levkau B, Ross R, Raines EW (1999) Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talin. J. Cell Biol. 147(3);619-30.
PMID:10551883 Low BC, Lim YP, Lim J, Wong ES, Guy GR (1999) Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42. J. Biol. Chem. 274(46);33123-30.
PMID:10559936 Edwards DC, Sanders LC, Bokoch GM, Gill GN (1999) Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat. Cell Biol. 1(5);253-9.
PMID:10579713 Tatsumoto T, Xie X, Blumenthal R, Okamoto I, Miki T (1999) Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J. Cell Biol. 147(5);921-8.
PMID:10581160 Jho Eh, Lomvardas S, Costantini F (1999) A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression. Biochem. Biophys. Res. Commun. 266(1);28-35.
PMID:10581193 Kojima T, Sawada N, Chiba H, Kokai Y, Yamamoto M, Urban M, Lee GH, Hertzberg EL, Mochizuki Y, Spray DC (1999) Induction of tight junctions in human connexin 32 (hCx32)-transfected mouse hepatocytes: connexin 32 interacts with occludin. Biochem. Biophys. Res. Commun. 266(1);222-9.
PMID:10593980 Roura S, Miravet S, Piedra J, Garc–a de Herreros A, Du–ach M (1999) Regulation of E-cadherin/Catenin association by tyrosine phosphorylation. J. Biol. Chem. 274(51);36734-40.
PMID:10613909 Sumi T, Matsumoto K, Takai Y, Nakamura T (1999) Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. J. Cell Biol. 147(7);1519-32.
PMID:10613913 Cordenonsi M, D’Atri F, Hammar E, Parry DA, Kendrick-Jones J, Shore D, Citi S (1999) Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin. J. Cell Biol. 147(7);1569-82.
PMID:10652228 Kato J, Kaziro Y, Satoh T (2000) Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation. Biochem. Biophys. Res. Commun. 268(1);141-7.
PMID:10671552 Lickert H, Bauer A, Kemler R, Stappert J (2000) Casein kinase II phosphorylation of E-cadherin increases E-cadherin/beta-catenin interaction and strengthens cell-cell adhesion. J. Biol. Chem. 275(7);5090-5.
PMID:10679324 Tolias KF, Hartwig JH, Ishihara H, Shibasaki Y, Cantley LC, Carpenter CL (2000) Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr. Biol. 10(3);153-6.
PMID:10679481 Doble BW, Ping P, Kardami E (2000) The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation. Circ. Res. 86(3);293-301.
PMID:10685062 Vestweber D (2000) Molecular mechanisms that control endothelial cell contacts. J. Pathol. 190(3);281-91.
PMID:10769036 Kulkarni SV, Gish G, van der Geer P, Henkemeyer M, Pawson T (2000) Role of p120 Ras-GAP in directed cell movement. J. Cell Biol. 149(2);457-70.
PMID:10816584 Pirone DM, Fukuhara S, Gutkind JS, Burbelo PD (2000) SPECs, small binding proteins for Cdc42. J. Biol. Chem. 275(30);22650-6.
PMID:10837491 Kimura K, Tsuji T, Takada Y, Miki T, Narumiya S (2000) Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation. J. Biol. Chem. 275(23);17233-6.
PMID:10871288 Lampe PD, TenBroek EM, Burt JM, Kurata WE, Johnson RG, Lau AF (2000) Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication. J. Cell Biol. 149(7);1503-12.
PMID:10871881 Doerks T, Bork P, Kamberov E, Makarova O, Muecke S, Margolis B (2000) L27, a novel heterodimerization domain in receptor targeting proteins Lin-2 and Lin-7. Trends Biochem. Sci. 25(7);317-8.
PMID:10873802 Qiu RG, Abo A, Steven Martin G (2000) A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation. Curr. Biol. 10(12);697-707.
PMID:10934474 Joberty G, Petersen C, Gao L, Macara IG (2000) The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat. Cell Biol. 2(8);531-9.
PMID:10934475 Lin D, Edwards AS, Fawcett JP, Mbamalu G, Scott JD, Pawson T (2000) A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat. Cell Biol. 2(8);540-7.
PMID:10940259 Pollard TD, Blanchoin L, Mullins RD (2000) Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct 29;545-76.
PMID:10954424 Johansson A, Driessens M, Aspenstr–m P (2000) The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J. Cell. Sci. 113 ( Pt 18);3267-75.
PMID:11035016 Hirsch DS, Pirone DM, Burbelo PD (2000) A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. J. Biol. Chem. 276(2);875-83.
PMID:11074002 Pierreux CE, Nicol–s FJ, Hill CS (2000) Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus. Mol. Cell. Biol. 20(23);9041-54.
PMID:11080163 Doody GM, Billadeau DD, Clayton E, Hutchings A, Berland R, McAdam S, Leibson PJ, Turner M (2000) Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes. EMBO J. 19(22);6173-84.
PMID:11114741 Parsons JT, Martin KH, Slack JK, Taylor JM, Weed SA (2000) Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene 19(49);5606-13.
PMID:11121431 Alahari SK, Lee JW, Juliano RL (2000) Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration. J. Cell Biol. 151(6);1141-54.
PMID:11133108 Maillot C, Gargala G, Delaunay A, Ducrotte P, Brasseur P, Ballet JJ, Favennec L (2001) Cryptosporidium parvum infection stimulates the secretion of TGF-beta, IL-8 and RANTES by Caco-2 cell line. Parasitol. Res. 86(12);947-9.
PMID:11149925 Michaelson D, Silletti J, Murphy G, D’Eustachio P, Rush M, Philips MR (2001) Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding. J. Cell Biol. 152(1);111-26.
PMID:11152757 Takai Y, Sasaki T, Matozaki T (2001) Small GTP-binding proteins. Physiol. Rev. 81(1);153-208.
PMID:11248548 Erickson JW, Cerione RA (2001) Multiple roles for Cdc42 in cell regulation. Curr. Opin. Cell Biol. 13(2);153-7.
PMID:11309411 Tiwari-Woodruff SK, Buznikov AG, Vu TQ, Micevych PE, Chen K, Kornblum HI, Bronstein JM (2001) OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes. J. Cell Biol. 153(2);295-305.
PMID:11313345 Laing JG, Manley-Markowski RN, Koval M, Civitelli R, Steinberg TH (2001) Connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cells. J. Biol. Chem. 276(25);23051-5.
PMID:11340065 Sumi T, Matsumoto K, Shibuya A, Nakamura T (2001) Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. J. Biol. Chem. 276(25);23092-6.
PMID:11348595 Huber AH, Weis WI (2001) The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell 105(3);391-402.
PMID:11368848 Faur– J, Dagher MC (2001) Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI). Biochimie 83(5);409-14.
PMID:11394904 Kato-Stankiewicz J, Ueda S, Kataoka T, Kaziro Y, Satoh T (2001) Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner. Biochem. Biophys. Res. Commun. 284(2);470-7.
PMID:11413130 Dan C, Kelly A, Bernard O, Minden A (2001) Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin. J. Biol. Chem. 276(34);32115-21.
PMID:11413131 Corps E, Carter C, Karecla P, Ahrens T, Evans P, Kilshaw P (2001) Recognition of E-cadherin by integrin alpha(E)beta(7): requirement for cadherin dimerization and implications for cadherin and integrin function. J. Biol. Chem. 276(33);30862-70.
PMID:11487578 Rubinfeld B, Tice DA, Polakis P (2001) Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon. J. Biol. Chem. 276(42);39037-45.
PMID:11553709 Voura EB, Ramjeesingh RA, Montgomery AM, Siu CH (2001) Involvement of integrin alpha(v)beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells. Mol. Biol. Cell 12(9);2699-710.
PMID:11557048 Kausalya PJ, Reichert M, Hunziker W (2001) Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells. FEBS Lett. 505(1);92-6.
PMID:11689568 Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S (2001) Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J. Biol. Chem. 277(1);455-61.
PMID:11706054 Mechtersheimer S, Gutwein P, Agmon-Levin N, Stoeck A, Oleszewski M, Riedle S, Postina R, Fahrenholz F, Fogel M, Lemmon V, Altevogt P (2001) Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins. J. Cell Biol. 155(4);661-73.
PMID:11713255 Lambert JM, Karnoub AE, Graves LM, Campbell SL, Der CJ (2001) Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation. J. Biol. Chem. 277(7);4770-7.
PMID:11724822 Taya S, Inagaki N, Sengiku H, Makino H, Iwamatsu A, Urakawa I, Nagao K, Kataoka S, Kaibuchi K (2001) Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF. J. Cell Biol. 155(5);809-20.
PMID:11728826 Hagemann C, Blank JL (2001) The ups and downs of MEK kinase interactions. Cell. Signal. 13(12);863-75.
PMID:11729192 Chen ML, Pothoulakis C, LaMont JT (2001) Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A. J. Biol. Chem. 277(6);4247-54.
PMID:11739775 Rajasekaran SA, Palmer LG, Moon SY, Peralta Soler A, Apodaca GL, Harper JF, Zheng Y, Rajasekaran AK (2001) Na,K-ATPase activity is required for formation of tight junctions, desmosomes, and induction of polarity in epithelial cells. Mol. Biol. Cell 12(12);3717-32.
PMID:11740559 Hong Y, Stronach B, Perrimon N, Jan LY, Jan YN (2001) Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts. Nature 414(6864);634-8.
PMID:11740560 Bachmann A, Schneider M, Theilenberg E, Grawe F, Knust E (2001) Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Nature 414(6864);638-43.
PMID:11927608 Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (2002) The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. J. Cell Biol. 157(1);161-72.
PMID:11950587 Jaffer ZM, Chernoff J (2002) p21-activated kinases: three more join the Pak. Int. J. Biochem. Cell Biol. 34(7);713-7.
PMID:11955436 Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X (2002) Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108(6);837-47.
PMID:11967263 Hagen T, Di Daniel E, Culbert AA, Reith AD (2002) Expression and characterization of GSK-3 mutants and their effect on beta-catenin phosphorylation in intact cells. J. Biol. Chem. 277(26);23330-5.
PMID:11978007 Kojima T, Spray DC, Kokai Y, Chiba H, Mochizuki Y, Sawada N (2002) Cx32 formation and/or Cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytic cell line. Exp. Cell Res. 276(1);40-51.
PMID:11992112 Sahai E, Marshall CJ (2002) ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat. Cell Biol. 4(6);408-15.
PMID:12045227 Yonemura S, Matsui T, Tsukita S, Tsukita S (2002) Rho-dependent and -independent activation mechanisms of ezrin/radixin/moesin proteins: an essential role for polyphosphoinositides in vivo. J. Cell. Sci. 115(Pt 12);2569-80.
PMID:12051714 Hagen T, Vidal-Puig A (2002) Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45. Biochem. Biophys. Res. Commun. 294(2);324-8.
PMID:12054568 Miki H, Takenawa T (2002) WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac. Biochem. Biophys. Res. Commun. 293(1);93-9.
PMID:12123611 Murase S, Mosser E, Schuman EM (2002) Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function. Neuron 35(1);91-105.
PMID:12134164 Lambert JM, Lambert QT, Reuther GW, Malliri A, Siderovski DP, Sondek J, Collard JG, Der CJ (2002) Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat. Cell Biol. 4(8);621-5.
PMID:12165654 Michel F, Acuto O (2002) CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76? Sci. STKE 2002(144);pe35.
PMID:12181570 Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW (2002) Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 418(6899);790-3.
PMID:12221096 Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (2002) XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. J. Biol. Chem. 277(45);42964-72.
PMID:12297042 Hynes RO (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110(6);673-87.
PMID:12354099 Fukuhara A, Irie K, Yamada A, Katata T, Honda T, Shimizu K, Nakanishi H, Takai Y (2002) Role of nectin in organization of tight junctions in epithelial cells. Genes Cells 7(10);1059-72.
PMID:12361600 Vaezi A, Bauer C, Vasioukhin V, Fuchs E (2002) Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium. Dev. Cell 3(3);367-81.
PMID:12426320 Calkins CC, Hoepner BL, Law CM, Novak MR, Setzer SV, Hatzfeld M, Kowalczyk AP (2002) The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein. J. Biol. Chem. 278(3);1774-83.
PMID:12432077 C–t– JF, Vuori K (2002) Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J. Cell. Sci. 115(Pt 24);4901-13.
PMID:12480336 Moon SY, Zheng Y (2002) Rho GTPase-activating proteins in cell regulation. Trends Cell Biol. 13(1);13-22.
PMID:12490555 Aybar MJ, Nieto MA, Mayor R (2002) Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest. Development 130(3);483-94.
PMID:12545156 Wu S, Cetinkaya C, Munoz-Alonso MJ, von der Lehr N, Bahram F, Beuger V, Eilers M, Leon J, Larsson LG (2003) Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene 22(3);351-60.
PMID:12547828 Basuroy S, Sheth P, Kuppuswamy D, Balasubramanian S, Ray RM, Rao RK (2003) Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayer. J. Biol. Chem. 278(14);11916-24.
PMID:12554650 Dajani R, Fraser E, Roe SM, Yeo M, Good VM, Thompson V, Dale TC, Pearl LH (2003) Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. EMBO J. 22(3);494-501.
PMID:12604349 Kale G, Naren AP, Sheth P, Rao RK (2003) Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3. Biochem. Biophys. Res. Commun. 302(2);324-9.
PMID:12663502 Gotoh J, Obata M, Yoshie M, Kasai S, Ogawa K (2003) Cyclin D1 over-expression correlates with beta-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3 beta and ERK1/2 in mouse hepatic carcinogenesis. Carcinogenesis 24(3);435-42.
PMID:12668723 Ikenouchi J, Matsuda M, Furuse M, Tsukita S (2003) Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J. Cell. Sci. 116(Pt 10);1959-67.
PMID:12727824 Anders M, Christian C, McMahon M, McCormick F, Korn WM (2003) Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells. Cancer Res. 63(9);2088-95.
PMID:12743038 Postigo AA (2003) Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway. EMBO J. 22(10);2443-52.
PMID:12778124 Riento K, Ridley AJ (2003) Rocks: multifunctional kinases in cell behaviour. Nat. Rev. Mol. Cell Biol. 4(6);446-56.
PMID:12799363 Provost E, Yamamoto Y, Lizardi I, Stern J, D’Aquila TG, Gaynor RB, Rimm DL (2003) Functional correlates of mutations in beta-catenin exon 3 phosphorylation sites. J. Biol. Chem. 278(34);31781-9.
PMID:12808044 Nielsen PA, Baruch A, Shestopalov VI, Giepmans BN, Dunia I, Benedetti EL, Kumar NM (2003) Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1). Mol. Biol. Cell 14(6);2470-81.
PMID:12809600 Shi Y, Massagu– J (2003) Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113(6);685-700.
PMID:12857875 Nakazawa T, Watabe AM, Tezuka T, Yoshida Y, Yokoyama K, Umemori H, Inoue A, Okabe S, Manabe T, Yamamoto T (2003) p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling. Mol. Biol. Cell 14(7);2921-34.
PMID:14557817 Siegel PM, Massagu– J (2003) Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat. Rev. Cancer 3(11);807-21.
PMID:14570575 Hemler ME (2003) Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu. Rev. Cell Dev. Biol. 19;397-422.
PMID:14576341 Nicholson BJ (2003) Gap junctions – from cell to molecule. J. Cell. Sci. 116(Pt 22);4479-81.
PMID:14623871 Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze’ev A (2003) Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. J. Cell Biol. 163(4);847-57.
PMID:14633674 Hong C, Bollen AW, Costello JF (2003) The contribution of genetic and epigenetic mechanisms to gene silencing in oligodendrogliomas. Cancer Res. 63(22);7600-5.
PMID:14657501 Wang HR, Zhang Y, Ozdamar B, Ogunjimi AA, Alexandrova E, Thomsen GH, Wrana JL (2003) Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science 302(5651);1775-9.
PMID:14663202 Bijur GN, Jope RS (2003) Glycogen synthase kinase-3 beta is highly activated in nuclei and mitochondria. Neuroreport 14(18);2415-9.
PMID:14673164 Peinado H, Ballestar E, Esteller M, Cano A (2003) Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol. Cell. Biol. 24(1);306-19.
PMID:14681219 Weernink PA, Meletiadis K, Hommeltenberg S, Hinz M, Ishihara H, Schmidt M, Jakobs KH (2003) Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42. J. Biol. Chem. 279(9);7840-9.
PMID:14701795 Cheng L, Mahon GM, Kostenko EV, Whitehead IP (2004) Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1. J. Biol. Chem. 279(13);12786-93.
PMID:14712077 Rowlands TM, Pechenkina IV, Hatsell S, Cowin P (2004) Beta-catenin and cyclin D1: connecting development to breast cancer. Cell Cycle 3(2);145-8.
PMID:14718565 Straight SW, Shin K, Fogg VC, Fan S, Liu CJ, Roh M, Margolis B (2004) Loss of PALS1 expression leads to tight junction and polarity defects. Mol. Biol. Cell 15(4);1981-90.
PMID:14744429 Burridge K, Wennerberg K (2004) Rho and Rac take center stage. Cell 116(2);167-79.
PMID:15003621 Cerione RA (2004) Cdc42: new roads to travel. Trends Cell Biol. 14(3);127-32.
PMID:15020233 Takahashi-Yanaga F, Shiraishi F, Hirata M, Miwa Y, Morimoto S, Sasaguri T (2004) Glycogen synthase kinase-3beta is tyrosine-phosphorylated by MEK1 in human skin fibroblasts. Biochem. Biophys. Res. Commun. 316(2);411-5.
PMID:15020669 Etienne-Manneville S (2004) Cdc42–the centre of polarity. J. Cell. Sci. 117(Pt 8);1291-300.
PMID:15070779 Yamauchi K, Rai T, Kobayashi K, Sohara E, Suzuki T, Itoh T, Suda S, Hayama A, Sasaki S, Uchida S (2004) Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc. Natl. Acad. Sci. U.S.A. 101(13);4690-4.
PMID:15094799 Dayel MJ, Mullins RD (2004) Activation of Arp2/3 complex: addition of the first subunit of the new filament by a WASP protein triggers rapid ATP hydrolysis on Arp2. PLoS Biol. 2(4);E91.
PMID:15111329 Watanabe D, Takagi H, Suzuma K, Suzuma I, Oh H, Ohashi H, Kemmochi S, Uemura A, Ojima T, Suganami E, Miyamoto N, Sato Y, Honda Y (2004) Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization. Am. J. Pathol. 164(5);1827-35.
PMID:15140942 Powers JT, Hong S, Mayhew CN, Rogers PM, Knudsen ES, Johnson DG (2004) E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis. Mol. Cancer Res. 2(4);203-14.
PMID:15151915 Schneeberger EE, Lynch RD (2004) The tight junction: a multifunctional complex. Am. J. Physiol., Cell Physiol. 286(6);C1213-28.
PMID:15155580 Vega S, Morales AV, Oca–a OH, Vald–s F, Fabregat I, Nieto MA (2004) Snail blocks the cell cycle and confers resistance to cell death. Genes Dev. 18(10);1131-43.
PMID:15157156 Juliano RL, Reddig P, Alahari S, Edin M, Howe A, Aplin A (2004) Integrin regulation of cell signalling and motility. Biochem. Soc. Trans. 32(Pt3);443-6.
PMID:15229651 Alahari SK, Reddig PJ, Juliano RL (2004) The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK. EMBO J. 23(14);2777-88.
PMID:15292177 Umeda K, Matsui T, Nakayama M, Furuse K, Sasaki H, Furuse M, Tsukita S (2004) Establishment and characterization of cultured epithelial cells lacking expression of ZO-1. J. Biol. Chem. 279(43);44785-94.
PMID:15308668 Vall–s AM, Beuvin M, Boyer B (2004) Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells. J. Biol. Chem. 279(43);44490-6.
PMID:15327768 Ha NC, Tonozuka T, Stamos JL, Choi HJ, Weis WI (2004) Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol. Cell 15(4);511-21.
PMID:15377999 Esufali S, Bapat B (2004) Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation. Oncogene 23(50);8260-71.
PMID:15383321 Britt DE, Yang DF, Yang DQ, Flanagan D, Callanan H, Lim YP, Lin SH, Hixson DC (2004) Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Exp. Cell Res. 300(1);134-48.
PMID:15448698 Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, Hung MC (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 6(10);931-40.
PMID:15459715 Schlessinger K, Hall A (2004) GSK-3beta sets Snail’s pace. Nat. Cell Biol. 6(10);913-5.
PMID:15465828 Buss H, D–rrie A, Schmitz ML, Frank R, Livingstone M, Resch K, Kracht M (2004) Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity. J. Biol. Chem. 279(48);49571-4.
PMID:15471980 Radel C, Rizzo V (2004) Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization. Am. J. Physiol. Heart Circ. Physiol. 288(2);H936-45.
PMID:15501236 Hall H, Hubbell JA (2004) Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2. Microvasc. Res. 68(3);169-78.
PMID:15534005 Richards TS, Dunn CA, Carter WG, Usui ML, Olerud JE, Lampe PD (2004) Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368. J. Cell Biol. 167(3);555-62.
PMID:15548370 Xie L, Law BK, Chytil AM, Brown KA, Aakre ME, Moses HL (2004) Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro. Neoplasia 6(5);603-10.
PMID:15558297 Li X, Olson C, Lu S, Nagy JI (2004) Association of connexin36 with zonula occludens-1 in HeLa cells, betaTC-3 cells, pancreas, and adrenal gland. Histochem. Cell Biol. 122(5);485-98.
PMID:15574337 Chaussepied M, Ginsberg D (2004) Transcriptional regulation of AKT activation by E2F. Mol. Cell 16(5);831-7.
PMID:15609097 Goodwin M, Yap AS (2004) Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton. J. Mol. Histol. 35(8-9);839-44.
PMID:15688067 Mitra SK, Hanson DA, Schlaepfer DD (2005) Focal adhesion kinase: in command and control of cell motility. Nat. Rev. Mol. Cell Biol. 6(1);56-68.
PMID:15713627 Parsons M, Monypenny J, Ameer-Beg SM, Millard TH, Machesky LM, Peter M, Keppler MD, Schiavo G, Watson R, Chernoff J, Zicha D, Vojnovic B, Ng T (2005) Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Mol. Cell. Biol. 25(5);1680-95.
PMID:15716380 Gavert N, Conacci-Sorrell M, Gast D, Schneider A, Altevogt P, Brabletz T, Ben-Ze’ev A (2005) L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J. Cell Biol. 168(4);633-42.
PMID:15761148 Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL (2005) Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 307(5715);1603-9.
PMID:15761153 Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (2005) High-throughput mapping of a dynamic signaling network in mammalian cells. Science 307(5715);1621-5.
PMID:15782139 Fujimoto E, Sato H, Shirai S, Nagashima Y, Fukumoto K, Hagiwara H, Negishi E, Ueno K, Omori Y, Yamasaki H, Hagiwara K, Yano T (2005) Connexin32 as a tumor suppressor gene in a metastatic renal cell carcinoma cell line. Oncogene 24(22);3684-90.
PMID:15810077 Li YJ, Wei ZM, Meng YX, Ji XR (2005) Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis. World J. Gastroenterol. 11(14);2117-23.
PMID:15820557 Coyne CB, Bergelson JM (2005) CAR: a virus receptor within the tight junction. Adv. Drug Deliv. Rev. 57(6);869-82.
PMID:15866170 Otomo T, Otomo C, Tomchick DR, Machius M, Rosen MK (2005) Structural basis of Rho GTPase-mediated activation of the formin mDia1. Mol. Cell 18(3);273-81.
PMID:15866889 Danen EH, van Rheenen J, Franken W, Huveneers S, Sonneveld P, Jalink K, Sonnenberg A (2005) Integrins control motile strategy through a Rho-cofilin pathway. J. Cell Biol. 169(3);515-26.
PMID:15980428 Singh D, Solan JL, Taffet SM, Javier R, Lampe PD (2005) Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner. J. Biol. Chem. 280(34);30416-21.
PMID:16099633 Lilien J, Balsamo J (2005) The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin. Curr. Opin. Cell Biol. 17(5);459-65.
PMID:16112081 Winkler S, Mohl M, Wieland T, Lutz S (2005) GrinchGEF–a novel Rho-specific guanine nucleotide exchange factor. Biochem. Biophys. Res. Commun. 335(4);1280-6.
PMID:16129888 Michel D, Arsanto JP, Massey-Harroche D, B–clin C, Wijnholds J, Le Bivic A (2005) PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. J. Cell. Sci. 118(Pt 17);4049-57.
PMID:16199880 Maretzky T, Schulte M, Ludwig A, Rose-John S, Blobel C, Hartmann D, Altevogt P, Saftig P, Reiss K (2005) L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth. Mol. Cell. Biol. 25(20);9040-53.
PMID:16212495 Jaffe AB, Hall A (2005) Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21;247-69.
PMID:16232121 Mart–nez-Estrada OM, Culler–s A, Soriano FX, Peinado H, Bol–s V, Mart–nez FO, Reina M, Cano A, Fabre M, Vilar– S (2005) The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells. Biochem. J. 394(Pt 2);449-57.
PMID:16288291 Larue L, Bellacosa A (2005) Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways. Oncogene 24(50);7443-54.
PMID:16292343 Lammers M, Rose R, Scrima A, Wittinghofer A (2005) The regulation of mDia1 by autoinhibition and its release by Rho*GTP. EMBO J. 24(23);4176-87.
PMID:16293614 Torres E, Rosen MK (2005) Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP. J. Biol. Chem. 281(6);3513-20.
PMID:16325583 Drees F, Pokutta S, Yamada S, Nelson WJ, Weis WI (2005) Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell 123(5);903-15.
PMID:16359940 Oyamada M, Oyamada Y, Takamatsu T (2005) Regulation of connexin expression. Biochim. Biophys. Acta 1719(1-2);6-23.
PMID:16371504 Qi J, Wang J, Romanyuk O, Siu CH (2005) Involvement of Src family kinases in N-cadherin phosphorylation and beta-catenin dissociation during transendothelial migration of melanoma cells. Mol. Biol. Cell 17(3);1261-72.
PMID:16377081 Stoeck A, Schlich S, Issa Y, Gschwend V, Wenger T, Herr I, Marm– A, Bourbie S, Altevogt P, Gutwein P (2005) L1 on ovarian carcinoma cells is a binding partner for Neuropilin-1 on mesothelial cells. Cancer Lett. 239(2);212-26.
PMID:16472676 Wang HR, Ogunjimi AA, Zhang Y, Ozdamar B, Bose R, Wrana JL (2006) Degradation of RhoA by Smurf1 ubiquitin ligase. Meth. Enzymol. 406;437-47.
PMID:16474430 Li H, Xu D, Toh BH, Liu JP (2006) TGF-beta and cancer: is Smad3 a repressor of hTERT gene? Cell Res. 16(2);169-73.
PMID:16492141 Laird DW (2006) Life cycle of connexins in health and disease. Biochem. J. 394(Pt 3);527-43.
PMID:16506207 Meier F, Busch S, Gast D, G–ppert A, Altevogt P, Maczey E, Riedle S, Garbe C, Schittek B (2006) The adhesion molecule L1 (CD171) promotes melanoma progression. Int. J. Cancer 119(3);549-55.
PMID:16510505 Sakai D, Suzuki T, Osumi N, Wakamatsu Y (2006) Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development. Development 133(7);1323-33.
PMID:16519628 Tcherkezian J, Triki I, Stenne R, Danek EI, Lamarche-Vane N (2006) The human orthologue of CdGAP is a phosphoprotein and a GTPase-activating protein for Cdc42 and Rac1 but not RhoA. Biol. Cell 98(8);445-56.
PMID:16542650 Raschperger E, Thyberg J, Pettersson S, Philipson L, Fuxe J, Pettersson RF (2006) The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis. Exp. Cell Res. 312(9);1566-80.
PMID:16617148 Peir– S, Escriv– M, Puig I, Barber– MJ, Dave N, Herranz N, Larriba MJ, Takkunen M, Franc– C, Mu–oz A, Virtanen I, Baulida J, Garc–a de Herreros A (2006) Snail1 transcriptional repressor binds to its own promoter and controls its expression. Nucleic Acids Res. 34(7);2077-84.
PMID:16650609 Ciolofan C, Li XB, Olson C, Kamasawa N, Gebhardt BR, Yasumura T, Morita M, Rash JE, Nagy JI (2006) Association of connexin36 and zonula occludens-1 with zonula occludens-2 and the transcription factor zonula occludens-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retina. Neuroscience 140(2);433-51.
PMID:16678097 Wells CD, Fawcett JP, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C, Colwill K, Starostine A, Metalnikov P, Pawson T (2006) A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell 125(3);535-48.
PMID:16702231 Suetsugu S, Kurisu S, Oikawa T, Yamazaki D, Oda A, Takenawa T (2006) Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac. J. Cell Biol. 173(4);571-85.
PMID:16710477 Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D (2006) Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J. Clin. Invest. 116(6);1606-14.
PMID:16917499 Kamon H, Kawabe T, Kitamura H, Lee J, Kamimura D, Kaisho T, Akira S, Iwamatsu A, Koga H, Murakami M, Hirano T (2006) TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation. EMBO J. 25(17);4108-19.
PMID:16919435 Mitra SK, Schlaepfer DD (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 18(5);516-23.
PMID:16940750 Katoh M, Katoh M (2006) Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades. Cancer Biol. Ther. 5(9);1059-64.
PMID:16944320 Jope RS, Yuskaitis CJ, Beurel E (2006) Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem. Res. 32(4-5);577-95.
PMID:17012742 Straight SW, Pieczynski JN, Whiteman EL, Liu CJ, Margolis B (2006) Mammalian lin-7 stabilizes polarity protein complexes. J. Biol. Chem. 281(49);37738-47.
PMID:17018611 Moreno-Bueno G, Cubillo E, Sarri– D, Peinado H, Rodr–guez-Pinilla SM, Villa S, Bol–s V, Jord– M, Fabra A, Portillo F, Palacios J, Cano A (2006) Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition. Cancer Res. 66(19);9543-56.
PMID:17045588 Ching KH, Kisailus AE, Burbelo PD (2006) Biochemical characterization of distinct regions of SPEC molecules and their role in phagocytosis. Exp. Cell Res. 313(1);10-21.
PMID:17093497 Boutet A, De Frutos CA, Maxwell PH, Mayol MJ, Romero J, Nieto MA (2006) Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J. 25(23);5603-13.
PMID:17143293 Arce L, Yokoyama NN, Waterman ML (2006) Diversity of LEF/TCF action in development and disease. Oncogene 25(57);7492-504.
PMID:17143294 Barolo S (2006) Transgenic Wnt/TCF pathway reporters: all you need is Lef? Oncogene 25(57);7505-11.
PMID:17145883 Shtutman M, Levina E, Ohouo P, Baig M, Roninson IB (2006) Cell adhesion molecule L1 disrupts E-cadherin-containing adherens junctions and increases scattering and motility of MCF7 breast carcinoma cells. Cancer Res. 66(23);11370-80.
PMID:17161586 Zhao J, Pei DS, Zhang QG, Zhang GY (2006) Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus. Cell. Signal. 19(4);831-43.
PMID:17299729 Castro Alves C, Rosivatz E, Schott C, Hollweck R, Becker I, Sarbia M, Carneiro F, Becker KF (2007) Slug is overexpressed in gastric carcinomas and may act synergistically with SIP1 and Snail in the down-regulation of E-cadherin. J. Pathol. 211(5);507-15.
PMID:17318175 Luo W, Peterson A, Garcia BA, Coombs G, Kofahl B, Heinrich R, Shabanowitz J, Hunt DF, Yost HJ, Virshup DM (2007) Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J. 26(6);1511-21.
PMID:17325197 Le Floc’h A, Jalil A, Vergnon I, Le Maux Chansac B, Lazar V, Bismuth G, Chouaib S, Mami-Chouaib F (2007) Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis. J. Exp. Med. 204(3);559-70.
PMID:17353278 Dupre-Crochet S, Figueroa A, Hogan C, Ferber EC, Bialucha CU, Adams J, Richardson EC, Fujita Y (2007) Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts. Mol. Cell. Biol. 27(10);3804-16.
PMID:17486063 Aigner K, Dampier B, Descovich L, Mikula M, Sultan A, Schreiber M, Mikulits W, Brabletz T, Strand D, Obrist P, Sommergruber W, Schweifer N, Wernitznig A, Beug H, Foisner R, Eger A (2007) The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene 26(49);6979-88.
PMID:17490644 Jord– M, Vinyals A, Marazuela A, Cubillo E, Olmeda D, Valero E, Cano A, Fabra A (2007) Id-1 is induced in MDCK epithelial cells by activated Erk/MAPK pathway in response to expression of the Snail and E47 transcription factors. Exp. Cell Res. 313(11);2389-403.
PMID:17498653 Radel C, Carlile-Klusacek M, Rizzo V (2007) Participation of caveolae in beta1 integrin-mediated mechanotransduction. Biochem. Biophys. Res. Commun. 358(2);626-31.
PMID:17537911 Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, Kutok JL, Hartwell K, Richardson AL, Weinberg RA (2007) Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc. Natl. Acad. Sci. U.S.A. 104(24);10069-74.
PMID:17563753 Julien S, Puig I, Caretti E, Bonaventure J, Nelles L, van Roy F, Dargemont C, de Herreros AG, Bellacosa A, Larue L (2007) Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene 26(53);7445-56.
PMID:17568974 Kojima T, Murata M, Go M, Spray DC, Sawada N (2007) Connexins induce and maintain tight junctions in epithelial cells. J. Membr. Biol. 217(1-3);13-9.
PMID:17575049 Kitzing TM, Sahadevan AS, Brandt DT, Knieling H, Hannemann S, Fackler OT, Grosshans J, Grosse R (2007) Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. Genes Dev. 21(12);1478-83.
PMID:17671186 Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, Zhao J (2007) Kr–ppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Cancer Res. 67(15);7184-93.
PMID:17681699 Ciolofan C, Lynn BD, Wellershaus K, Willecke K, Nagy JI (2007) Spatial relationships of connexin36, connexin57 and zonula occludens-1 in the outer plexiform layer of mouse retina. Neuroscience 148(2);473-88.
PMID:17699774 Gavert N, Sheffer M, Raveh S, Spaderna S, Shtutman M, Brabletz T, Barany F, Paty P, Notterman D, Domany E, Ben-Ze’ev A (2007) Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. Cancer Res. 67(16);7703-12.
PMID:17928543 Daugherty RL, Gottardi CJ (2007) Phospho-regulation of Beta-catenin adhesion and signaling functions. Physiology (Bethesda) 22;303-9.
PMID:17934056 Li H, Liu JP (2007) Mechanisms of action of TGF-beta in cancer: evidence for Smad3 as a repressor of the hTERT gene. Ann. N. Y. Acad. Sci. 1114;56-68.
PMID:17952127 Gast D, Riedle S, Issa Y, Pfeifer M, Beckhove P, Sanderson MP, Arlt M, Moldenhauer G, Fogel M, Kr–ger A, Altevogt P (2007) The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies. Oncogene 27(9);1281-9.
PMID:18005931 Ass–mat E, Bazelli–res E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D (2007) Polarity complex proteins. Biochim. Biophys. Acta 1778(3);614-30.
PMID:18172008 Escriv– M, Peir– S, Herranz N, Villagrasa P, Dave N, Montserrat-Sent–s B, Murray SA, Franc– C, Gridley T, Virtanen I, Garc–a de Herreros A (2008) Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol. Cell. Biol. 28(5);1528-40.
PMID:18177979 Bachmann A, Grawe F, Johnson K, Knust E (2008) Drosophila Lin-7 is a component of the Crumbs complex in epithelia and photoreceptor cells and prevents light-induced retinal degeneration. Eur. J. Cell Biol. 87(3);123-36.
PMID:18297062 Yang MH, Wu MZ, Chiou SH, Chen PM, Chang SY, Liu CJ, Teng SC, Wu KJ (2008) Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat. Cell Biol. 10(3);295-305.
PMID:18342983 Wipff PJ, Hinz B (2008) Integrins and the activation of latent transforming growth factor beta1 – an intimate relationship. Eur. J. Cell Biol. 87(8-9);601-15.
PMID:18376396 Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, Vadas MA, Khew-Goodall Y, Goodall GJ (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat. Cell Biol. 10(5);593-601.
PMID:18719708 Heasman SJ, Ridley AJ (2008) Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat. Rev. Mol. Cell Biol. 9(9);690-701.
PMID:18815262 Li X, Kamasawa N, Ciolofan C, Olson CO, Lu S, Davidson KG, Yasumura T, Shigemoto R, Rash JE, Nagy JI (2008) Connexin45-containing neuronal gap junctions in rodent retina also contain connexin36 in both apposing hemiplaques, forming bihomotypic gap junctions, with scaffolding contributed by zonula occludens-1. J. Neurosci. 28(39);9769-89.
PMID:18829532 Shen CH, Chen HY, Lin MS, Li FY, Chang CC, Kuo ML, Settleman J, Chen RH (2008) Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. Cancer Res. 68(19);7779-87.
PMID:18931829 Issa Y, Nummer D, Seibel T, M–erk–ster SS, Koch M, Schmitz-Winnenthal FH, Galindo L, Weitz J, Beckhove P, Altevogt P (2008) Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration. J. Mol. Med. 87(1);99-112.
PMID:19017651 Elias BC, Suzuki T, Seth A, Giorgianni F, Kale G, Shen L, Turner JR, Naren A, Desiderio DM, Rao R (2008) Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. J. Biol. Chem. 284(3);1559-69.
PMID:19020303 Klein EA, Assoian RK (2008) Transcriptional regulation of the cyclin D1 gene at a glance. J. Cell. Sci. 121(Pt 23);3853-7.
PMID:19161977 Johnson MS, Lu N, Denessiouk K, Heino J, Gullberg D (2009) Integrins during evolution: evolutionary trees and model organisms. Biochim. Biophys. Acta 1788(4);779-89.
PMID:19208835 Inuzuka T, Tsuda M, Tanaka S, Kawaguchi H, Higashi Y, Ohba Y (2009) Integral role of transcription factor 8 in the negative regulation of tumor angiogenesis. Cancer Res. 69(4);1678-84.
PMID:19244118 Gandellini P, Folini M, Longoni N, Pennati M, Binda M, Colecchia M, Salvioni R, Supino R, Moretti R, Limonta P, Valdagni R, Daidone MG, Zaffaroni N (2009) miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon. Cancer Res. 69(6);2287-95.
PMID:19260824 Riedle S, Kiefel H, Gast D, Bondong S, Wolterink S, Gutwein P, Altevogt P (2009) Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity. Biochem. J. 420(3);391-402.
PMID:19273627 Maddaluno L, Verbrugge SE, Martinoli C, Matteoli G, Chiavelli A, Zeng Y, Williams ED, Rescigno M, Cavallaro U (2009) The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells. J. Exp. Med. 206(3);623-35.
PMID:19284610 Dbouk HA, Mroue RM, El-Sabban ME, Talhouk RS (2009) Connexins: a myriad of functions extending beyond assembly of gap junction channels. Cell Commun. Signal 7;4.
PMID:19339212 Oh MA, Choi S, Lee MJ, Choi MC, Lee SA, Ko W, Cance WG, Oh ES, Buday L, Kim SH, Lee JW (2009) Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes. Biochim. Biophys. Acta 1793(5);781-91.
PMID:19356150 Herron LR, Hill M, Davey F, Gunn-Moore FJ (2009) The intracellular interactions of the L1 family of cell adhesion molecules. Biochem. J. 419(3);519-31.
PMID:19401151 Friedli A, Fischer E, Novak-Hofer I, Cohrs S, Ballmer-Hofer K, Schubiger PA, Schibli R, Gr–nberg J (2009) The soluble form of the cancer-associated L1 cell adhesion molecule is a pro-angiogenic factor. Int. J. Biochem. Cell Biol. 41(7);1572-80.
PMID:19412634 Waldmann J, Slater EP, Langer P, Buchholz M, Ramaswamy A, Walz MK, Schmid KW, Feldmann G, Bartsch DK, Fendrich V (2009) Expression of the transcription factor snail and its target gene twist are associated with malignancy in pheochromocytomas. Ann. Surg. Oncol. 16(7);1997-2005.
PMID:19418635 Li X, Lu S, Nagy JI (2009) Direct association of connexin36 with zonula occludens-2 and zonula occludens-3. Neurochem. Int. 54(5-6);393-402.
PMID:19435915 Geismann C, Morscheck M, Koch D, Bergmann F, Ungefroren H, Arlt A, Tsao MS, Bachem MG, Altevogt P, Sipos B, F–lsch UR, Sch–fer H, M–erk–ster SS (2009) Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer. Cancer Res. 69(10);4517-26.
PMID:19439604 Puller C, de Sevilla M–ller LP, Janssen-Bienhold U, Haverkamp S (2009) ZO-1 and the spatial organization of gap junctions and glutamate receptors in the outer plexiform layer of the mammalian retina. J. Neurosci. 29(19);6266-75.
PMID:19448627 Wang SP, Wang WL, Chang YL, Wu CT, Chao YC, Kao SH, Yuan A, Lin CW, Yang SC, Chan WK, Li KC, Hong TM, Yang PC (2009) p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug. Nat. Cell Biol. 11(6);694-704.
PMID:19487819 Zeisberg M, Neilson EG (2009) Biomarkers for epithelial-mesenchymal transitions. J. Clin. Invest. 119(6);1429-37.
PMID:19597490 Vincent T, Neve EP, Johnson JR, Kukalev A, Rojo F, Albanell J, Pietras K, Virtanen I, Philipson L, Leopold PL, Crystal RG, de Herreros AG, Moustakas A, Pettersson RF, Fuxe J (2009) A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat. Cell Biol. 11(8);943-50.
PMID:19646399 Wang Z, Schey KL (2010) Phosphorylation and truncation sites of bovine lens connexin 46 and connexin 50. Exp. Eye Res. 89(6);898-904.
PMID:19703993 Saydam O, Shen Y, W–rdinger T, Senol O, Boke E, James MF, Tannous BA, Stemmer-Rachamimov AO, Yi M, Stephens RM, Fraefel C, Gusella JF, Krichevsky AM, Breakefield XO (2009) Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway. Mol. Cell. Biol. 29(21);5923-40.
PMID:19751508 Prasad CP, Rath G, Mathur S, Bhatnagar D, Parshad R, Ralhan R (2009) Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast. BMC Cancer 9;325.
PMID:19839049 Tryndyak VP, Beland FA, Pogribny IP (2010) E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. Int. J. Cancer 126(11);2575-83.
PMID:19854168 Rozario T, DeSimone DW (2010) The extracellular matrix in development and morphogenesis: a dynamic view. Dev. Biol. 341(1);126-40.
PMID:19920116 Massuto DA, Kneese EC, Johnson GA, Burghardt RC, Hooper RN, Ing NH, Jaeger LA (2010) Transforming growth factor beta (TGFB) signaling is activated during porcine implantation: proposed role for latency-associated peptide interactions with integrins at the conceptus-maternal interface. Reproduction 139(2);465-78.
PMID:19931509 Xia H, Ng SS, Jiang S, Cheung WK, Sze J, Bian XW, Kung HF, Lin MC (2010) miR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion. Biochem. Biophys. Res. Commun. 391(1);535-41.
PMID:19935649 Wellner U, Schubert J, Burk UC, Schmalhofer O, Zhu F, Sonntag A, Waldvogel B, Vannier C, Darling D, zur Hausen A, Brunton VG, Morton J, Sansom O, Sch–ler J, Stemmler MP, Herzberger C, Hopt U, Keck T, Brabletz S, Brabletz T (2009) The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat. Cell Biol. 11(12);1487-95.
PMID:19955337 Desai BV, Harmon RM, Green KJ (2010) Desmosomes at a glance. J. Cell. Sci. 122(Pt 24);4401-7.
PMID:20044598 Weidle UH, Eggle D, Klostermann S (2010) L1-CAM as a target for treatment of cancer with monoclonal antibodies. Anticancer Res. 29(12);4919-31.
PMID:20152177 Du D, Xu F, Yu L, Zhang C, Lu X, Yuan H, Huang Q, Zhang F, Bao H, Jia L, Wu X, Zhu X, Zhang X, Zhang Z, Chen Z (2010) The tight junction protein, occludin, regulates the directional migration of epithelial cells. Dev. Cell 18(1);52-63.
PMID:20501702 Gavert N, Ben-Shmuel A, Lemmon V, Brabletz T, Ben-Ze’ev A (2010) Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells. J. Cell. Sci. 123(Pt 12);2135-43.
PMID:20519943 Fuxe J, Vincent T, Garcia de Herreros A (2011) Transcriptional crosstalk between TGF— and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes. Cell Cycle 9(12);2363-74.
PMID:20592490 Mongroo PS, Rustgi AK (2011) The role of the miR-200 family in epithelial-mesenchymal transition. Cancer Biol. Ther. 10(3);219-22.
PMID:20702634 McKenna DJ, McDade SS, Patel D, McCance DJ (2011) MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6. J. Virol. 84(20);10644-52.
PMID:20706219 Brabletz S, Brabletz T (2010) The ZEB/miR-200 feedback loop–a motor of cellular plasticity in development and cancer? EMBO Rep. 11(9);670-7.
PMID:20731704 Sun W, Yang S, Shen W, Li H, Gao Y, Zhu TH (2010) Identification of DeltaEF1 as a novel target that is negatively regulated by LMO2 in T-cell leukemia. Eur. J. Haematol. 85(6);508-19.
PMID:21051664 Yang B, Radel C, Hughes D, Kelemen S, Rizzo V (2011) p190 RhoGTPase-activating protein links the –1 integrin/caveolin-1 mechanosignaling complex to RhoA and actin remodeling. Arterioscler. Thromb. Vasc. Biol. 31(2);376-83.
PMID:21051859 Hugo HJ, Kokkinos MI, Blick T, Ackland ML, Thompson EW, Newgreen DF (2011) Defining the E-cadherin repressor interactome in epithelial-mesenchymal transition: the PMC42 model as a case study. Cells Tissues Organs (Print) 193(1-2);23-40.
PMID:21081489 Chan YC, Khanna S, Roy S, Sen CK (2011) miR-200b targets Ets-1 and is down-regulated by hypoxia to induce angiogenic response of endothelial cells. J. Biol. Chem. 286(3);2047-56.
PMID:21109948 Geismann C, Arlt A, Bauer I, Pfeifer M, Schirmer U, Altevogt P, M–erk–ster SS, Sch–fer H (2011) Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming growth factor—1 (TGF—)-induced L1CAM expression in human pancreatic ductal adenocarcinoma cells. Int. J. Oncol. 38(1);257-66.
PMID:21123622 Gavert N, Vivanti A, Hazin J, Brabletz T, Ben-Ze’ev A (2011) L1-mediated colon cancer cell metastasis does not require changes in EMT and cancer stem cell markers. Mol. Cancer Res. 9(1);14-24.
PMID:21159887 Saini S, Majid S, Yamamura S, Tabatabai L, Suh SO, Shahryari V, Chen Y, Deng G, Tanaka Y, Dahiya R (2012) Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis. Clin. Cancer Res. 17(16);5287-98.
PMID:21195665 Kiefel H, Pfeifer M, Bondong S, Hazin J, Altevogt P (2011) Linking L1CAM-mediated signaling to NF—B activation. Trends Mol Med 17(4);178-87.
PMID:21199805 Casas E, Kim J, Bendesky A, Ohno-Machado L, Wolfe CJ, Yang J (2011) Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res. 71(1);245-54.
PMID:21209780 Le XF, Merchant O, Bast RC, Calin GA (2011) The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade. Cancer Microenviron 3(1);137-47.
PMID:21224848 Brabletz S, Bajdak K, Meidhof S, Burk U, Niedermann G, Firat E, Wellner U, Dimmler A, Faller G, Schubert J, Brabletz T (2011) The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J. 30(4);770-82.
PMID:21270398 March ME, Long EO (2011) –2 integrin induces TCR—Syk-phospholipase C— phosphorylation and paxillin-dependent granule polarization in human NK cells. J. Immunol. 186(5);2998-3005.
PMID:21317430 Dave N, Guaita-Esteruelas S, Gutarra S, Frias -?, Beltran M, Peir– S, de Herreros AG (2011) Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition. J. Biol. Chem. 286(14);12024-32.
PMID:21373966 Yang M, Li Y, Chilukuri K, Brady OA, Boulos MI, Kappes JC, Galileo DS (2012) L1 stimulation of human glioma cell motility correlates with FAK activation. J. Neurooncol. 105(1);27-44.
PMID:21518799 Kim T, Veronese A, Pichiorri F, Lee TJ, Jeon YJ, Volinia S, Pineau P, Marchio A, Palatini J, Suh SS, Alder H, Liu CG, Dejean A, Croce CM (2011) p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J. Exp. Med. 208(5);875-83.
PMID:21572392 Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L (2011) SCFFBXLa–?m regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. EMBO J. 30(13);2675-89.
PMID:21685935 Tong ZT, Cai MY, Wang XG, Kong LL, Mai SJ, Liu YH, Zhang HB, Liao YJ, Zheng F, Zhu W, Liu TH, Bian XW, Guan XY, Lin MC, Zeng MS, Zeng YX, Kung HF, Xie D (2012) EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin. Oncogene 31(5);583-94.
PMID:21777377 Zhang D, Chen C, Li Y, Fu X, Xie Y, Li Y, Huang Y (2012) Cx31.1 acts as a tumour suppressor in non-small cell lung cancer (NSCLC) cell lines through inhibition of cell proliferation and metastasis. J. Cell. Mol. Med. 16(5);1047-59.
PMID:21883379 Wu CY, Hung JJ, Wu KJ (2012) Linkage between Twist1 and Bmi1: molecular mechanism of cancer metastasis/stemness and clinical implications. Clin. Exp. Pharmacol. Physiol. 39(8);668-73.
PMID:21900405 Munger JS, Sheppard D (2012) Cross talk among TGF— signaling pathways, integrins, and the extracellular matrix. Cold Spring Harb Perspect Biol 3(11);a005017.
PMID:21965293 Chai Z, Goodenough DA, Paul DL (2012) Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels. Mol. Biol. Cell 22(23);4503-12.
PMID:22006115 Tran DD, Corsa CA, Biswas H, Aft RL, Longmore GD (2012) Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence. Mol. Cancer Res. 9(12);1644-57.
PMID:22022608 Francis R, Xu X, Park H, Wei CJ, Chang S, Chatterjee B, Lo C (2012) Connexin43 modulates cell polarity and directional cell migration by regulating microtubule dynamics. PLoS ONE 6(10);e26379.
PMID:22203675 Ulsamer A, Wei Y, Kim KK, Tan K, Wheeler S, Xi Y, Thies RS, Chapman HA (2012) Axin pathway activity regulates in vivo pY654—-catenin accumulation and pulmonary fibrosis. J. Biol. Chem. 287(7);5164-72.
PMID:22211245 Su J, Zhang A, Shi Z, Ma F, Pu P, Wang T, Zhang J, Kang C, Zhang Q (2012) MicroRNA-200a suppresses the Wnt/—catenin signaling pathway by interacting with —catenin. Int. J. Oncol. 40(4);1162-70.
PMID:22270359 Yan D, Avtanski D, Saxena NK, Sharma D (2012) Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires —catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways. J. Biol. Chem. 287(11);8598-612.
PMID:22286765 Ono H, Imoto I, Kozaki K, Tsuda H, Matsui T, Kurasawa Y, Muramatsu T, Sugihara K, Inazawa J (2013) SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation. Oncogene 31(47);4923-34.
PMID:22286770 Smith AL, Iwanaga R, Drasin DJ, Micalizzi DS, Vartuli RL, Tan AC, Ford HL (2013) The miR-106b-25 cluster targets Smad7, activates TGF— signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer. Oncogene 31(50);5162-71.
PMID:22311119 Kurashige J, Kamohara H, Watanabe M, Hiyoshi Y, Iwatsuki M, Tanaka Y, Kinoshita K, Saito S, Baba Y, Baba H (2013) MicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma. Ann. Surg. Oncol. 19 Suppl 3;S656-64.
PMID:22315516 D–rfel MJ, Huber O (2012) Modulation of tight junction structure and function by kinases and phosphatases targeting occludin. J. Biomed. Biotechnol. 2012;807356.
PMID:22349261 Gheldof A, Hulpiau P, van Roy F, De Craene B, Berx G (2012) Evolutionary functional analysis and molecular regulation of the ZEB transcription factors. Cell. Mol. Life Sci. 69(15);2527-41.
PMID:22370643 Liu YN, Yin JJ, Abou-Kheir W, Hynes PG, Casey OM, Fang L, Yi M, Stephens RM, Seng V, Sheppard-Tillman H, Martin P, Kelly K (2013) MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms. Oncogene 32(3);296-306.
PMID:22406545 Tiwari N, Gheldof A, Tatari M, Christofori G (2012) EMT as the ultimate survival mechanism of cancer cells. Semin. Cancer Biol. 22(3);194-207.
PMID:22514743 Moes M, Le B–chec A, Crespo I, Laurini C, Halavatyi A, Vetter G, Del Sol A, Friederich E (2012) A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition. PLoS ONE 7(4);e35440.
PMID:22564737 Patel D, Chaudhary J (2012) Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis. Biochem. Biophys. Res. Commun. 422(1);146-51.
PMID:22671595 Itallie CM, Anderson JM (2012) Caveolin binds independently to claudin-2 and occludin. Ann. N. Y. Acad. Sci. 1257;103-7.
PMID:22710166 Zi Z, Chapnick DA, Liu X (2012) Dynamics of TGF—/Smad signaling. FEBS Lett. 586(14);1921-8.
PMID:22753312 Hill L, Browne G, Tulchinsky E (2013) ZEB/miR-200 feedback loop: at the crossroads of signal transduction in cancer. Int. J. Cancer 132(4);745-54.
PMID:22796940 Le Bras GF, Taubenslag KJ, Andl CD (2013) The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression. Cell Adh Migr 6(4);365-73.
PMID:22881460 Tepass U (2013) The apical polarity protein network in Drosophila epithelial cells: regulation of polarity, junctions, morphogenesis, cell growth, and survival. Annu. Rev. Cell Dev. Biol. 28;655-85.
PMID:22943793 Kubiczkova L, Sedlarikova L, Hajek R, Sevcikova S (2013) TGF— – an excellent servant but a bad master. J Transl Med 10;183.
PMID:22945800 S–nchez-Till– E, Liu Y, de Barrios O, Siles L, Fanlo L, Cuatrecasas M, Darling DS, Dean DC, Castells A, Postigo A (2012) EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness. Cell. Mol. Life Sci. 69(20);3429-56.
PMID:22949611 Lim J, Thiery JP (2012) Epithelial-mesenchymal transitions: insights from development. Development 139(19);3471-86.
PMID:225147423 (0) ;.

Leave a Reply