EMT / EMT_REGULATORS
EMT / CYTOSKELETON_POLARITY
EMT / CELL_CELL_ADHESIONS
EMT / CELL_MATRIX_ADHESIONS
EMT / ECM
EMT / TIGHT_JUNCTIONS
EMT / GAP_JUNCTIONS
EMT / ADHERENS_JUNCTIONS
EMT / DESMOSOMES
e_re650( EMT ):
Connexin43 modulates cell polarity and directional cell migration by regulating microtubule dynamics.
e_re671( EMT ):
GJB5 is so-called Connexin 31.1
Cx31.1 (GJB5) is predominantly expressed in the testes and the skin epidermis.
Cx31.1 rarely form functional gap junction channels, either with itself or with other Cx isoforms.
Gap junctions play important roles in various physiologic functions such as regulation of cell proliferation, cell differentiation, tissue development and cell apoptosis.
In most cases, Cxs act as tumour suppressors: Gap junctions play an important role as tumour suppressors in maintaining cell differentiation and preventing transformation
Cx31.1 reduced tumour cell proliferation, anchorage-independent growth, migration and invasion.
Moreover, development of tumours in a xenograft model was suppressed by Cx31.1, suggesting that Cx31.1 may act as a tumour suppressor in NSCLC cell lines.
e_re1306( EMT ):
Of the 3 AKT isofomrs, AKT2 has been shown to promote cell motility, invasiveness and metastasis
s_wnc1_re142( Survival ):
Activated Daam1 is responisble for the inhibition
s_wnc1_re154( Survival ):
PTEN contains a C2-domain which inhibits cell migration. This inhibition works only when T383 is not phosphorylated
However, beta-arrestin can also bind PTEN in this C2-region thereby dis-inhibiting migration.
In compartment: Cytoplasm
In compartment: Nucleus
Participates in complexes:
Participates in reactions:
As Reactant or Product:
- AKT2@Cytoplasm → Cell migration@Cytoplasm
- ITGAV:ITGB3:L1CAM@Cytoplasm → Cell migration@Cytoplasm
- GJA1@Cytoplasm → Cell migration@Cytoplasm
- GJB5@Cytoplasm → Cell migration@Cytoplasm
- EMT@Cytoplasm → Cell migration@Cytoplasm
- NISCH:PAK1@Cytoplasm → Cell migration@Cytoplasm
- Membrane spreading@Cytoplasm → Cell migration@Cytoplasm
- s_s_wca1_s1651 → Cell migration@Cytoplasm
- s_s_wnc1_s1024 → Cell migration@Nucleus
- PTEN|pho|pho|pho|pho:_beta_-Arrestin*@Cytoplasm → Cell migration@Nucleus