Cell-matrix adhesions

Phenotype Cell-matrix adhesions map
Cell-matrix adhesions@Extracellular space

Identifiers
CELL_MATRIX_ADHESIONS

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map
 EMT  map  / ECM  map
 EMT  map  / TIGHT_JUNCTIONS  map
 EMT  map  / GAP_JUNCTIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map
 EMT  map  / DESMOSOMES  map

References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
PMID:12297042
Cell adhesion to components of the ECM is important in the angiogenesis
PMID:2153105
PMID:2786007
PMID:7639691
PMID:10809728
integrins are receptors for different ECM proteins: Collagen 1, 4; Laminin 1, 8; Fibronectin and Vitronectin
Laminin-8 interacts with integrins.
PMID:7522194
PMID:16195317
Interactions between integrins and the ECM proteins result in focal cell adhesion and cytoskeleton remodeling.
e_re713( EMT  map ):
PMID:8522586
PMID:8207064
Implication of ERM proteins in the regulation of cell-cell and cell-matrix adhesion:
Suppression of all three ERM proteins with antisense oligonucleotides disrupts cell-cell and cell-matrix adhesion
ERM family members are involved in cell-cell and cell-substrate adhesion, as well as microvilli formation.
PMID:9265657
ERM proteins can reconstitute stress fiber assembly, cortical actin polymerization and focal complex formation in response to activation of Rho and Rac


Modifications:
In compartment: Extracellular space
  1. Cell-matrix adhesions@Extracellular space map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. Laminin 1 partners*:​Laminin1*@Extracellular space map map Cell-matrix adhesions@Extracellular space map

    2. Elastin partners*:​Elastin*@Extracellular space map map Cell-matrix adhesions@Extracellular space map
    3. Galectin 3 partners*:​Galectin 3*@Extracellular space map map Cell-matrix adhesions@Extracellular space map
    4. Collagen1 partners*:​Collagen1*@Extracellular space map map Cell-matrix adhesions@Extracellular space map
    5. COL2A1:​Collagen2 partners*@Extracellular space map map Cell-matrix adhesions@Extracellular space map
    6. Fibronectin partners*:​Fibronectin*@Extracellular space map map Cell-matrix adhesions@Extracellular space map
    7. ERM*|​open@Cytoplasm map map Cell-matrix adhesions@Extracellular space map
    8. Laminin8*:​a6b1*_a6b4*@Extracellular space map map Cell-matrix adhesions@Extracellular space map
    9. Vitronectin*:​aVb3*_aVb5*@Extracellular space map map Cell-matrix adhesions@Extracellular space map
    10. Fibronectin*:​a5b1*_aVb3*@Extracellular space map map Cell-matrix adhesions@Extracellular space map
    11. Laminin1*:​a2b1*_a3b1*@Extracellular space map map Cell-matrix adhesions@Extracellular space map
    12. COL4A1:​a2b1*_a3b1*@Extracellular space map map Cell-matrix adhesions@Extracellular space map
    13. Collagen1*:​a1b1*_a2b1*@Extracellular space map map Cell-matrix adhesions@Extracellular space map

    As Catalyser:

      41 thoughts on “Cell-matrix adhesions

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