CDK2:CyclinE*

Complex CDK2:CyclinE* map


Complex composition:

  1. CDK2 map
  2. CyclinE* map




CDK2:​CyclinE*@Nucleus

Identifiers
NAME:CDK2:CyclinE*

Maps_Modules
 Cell cycle  map  / P27KIP  map
 Cell cycle  map  / CYCLINE  map

References
c_re306:( Cell cycle  map ) PMID:7799941
c_re147( Cell cycle  map ):
CDK activity stimulated by its CAK-complex phosphorylation.
PMID:12459251, PMID:12814430, PMID:7629134
c_re170( Cell cycle  map ):
Complex CYCLINE-CDK2 inhibited by its interaction with CKI.
PMID:10385618

Confidence
REF=2 FUNC=5

CDK2|​Thr160_pho:​CyclinE*|​Thr380_pho@Nucleus

Identifiers
NAME:CDK2:CyclinE*

Maps_Modules
 Cell cycle  map  / CYCLINE  map

References
c_re248( Cell cycle  map ):
Cyclin E phosphorylation by CDK2 at Thr-380.
PMID:8861947
Autophosphorylation of the complex CYCLINE/CDK2 at Thr-380 and Thr-62. Phosphorylation at Thr-380 also by GSK-3B. Two other sites of regulation: Ser-372 et Ser-384
PMID:16131838

Confidence
REF=1 FUNC=5

CDK2|​Thr160_pho:​CyclinE*@Nucleus

Identifiers
NAME:CDK2:CyclinE*

Maps_Modules
 Cell cycle  map  / CYCLINE  map
 Cell cycle  map  / RB  map

References
c_re147( Cell cycle  map ):
CDK activity stimulated by its CAK-complex phosphorylation.
PMID:12459251, PMID:12814430, PMID:7629134
c_re169( Cell cycle  map ):
Phosphorylation of p27 by cyclin E/CDK2 at Thr-187 results in targeting p27 for its degradation by proteolysis
PMID:10385618
c_re248( Cell cycle  map ):
Cyclin E phosphorylation by CDK2 at Thr-380.
PMID:8861947
Autophosphorylation of the complex CYCLINE/CDK2 at Thr-380 and Thr-62. Phosphorylation at Thr-380 also by GSK-3B. Two other sites of regulation: Ser-372 et Ser-384
PMID:16131838
c_re289:( Cell cycle  map ) PMID:12006580
c_re323( Cell cycle  map ):
pRB phosphorylation
PMID:9315635, PMID:12006580
Brg1 phosphorylation
PMID:11420722
Brg1 (in the SWI/SNF complex) and pRB are phosphorylated, simultaneously with the complex dissociation. Phosphorylation of pRB
Phosphorylation of Brg1 (SWI/SNF complex)
c_re327:( Cell cycle  map ) PMID:12836612
c_re1275:( Cell cycle  map ) PMID:15456871, PMID:12006580, PMID:11237530
c_re1276( Cell cycle  map ):
p130 binds to and inhibits CYCLINE-CDK2, independantly of its phosphorylation state.
PMID:15456871
PMID:12006580
PMID:11237530

Confidence
REF=5 FUNC=5

CDK2|​Tyr14_pho|​Tyr15_pho:​CyclinE*@Nucleus

Identifiers
NAME:CDK2:CyclinE*

Maps_Modules
 Cell cycle  map  / CYCLINE  map

Confidence
REF=0 FUNC=5

CDK2|​Y14/15_pho:​CyclinE*@default

Identifiers
NAME:CDK2:CyclinE*

Maps_Modules
 DNA repair  map  / G1_CC_PHASE  map

Confidence
REF=0 FUNC=5

CDK2|​T160_pho|​Y14/15_pho:​CyclinE*@default

Identifiers
NAME:CDK2:CyclinE*

Maps_Modules
 DNA repair  map  / G1_CC_PHASE  map

Confidence
REF=0 FUNC=5

CDK2:​CyclinE*@default

Identifiers
NAME:CDK2:CyclinE*

Maps_Modules
 DNA repair  map  / G1_CC_PHASE  map

Confidence
REF=0 FUNC=5

(CDK2|​T160_pho:​CyclinE*)|​active@default

Identifiers
NAME:CDK2:CyclinE*

Maps_Modules
 DNA repair  map  / G1_CC_PHASE  map

References
d_re115( DNA repair  map ):
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
d_re355( DNA repair  map ):
For role of TIM1*/TIPIN in S-phase checkpoint, replication arrest, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
d_re415:( DNA repair  map ) PMID:17038621, PMID:15677884

Confidence
REF=5 FUNC=5


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. CDK2:​CyclinE*@Nucleus map

  2. CDK2|​Thr160_pho:​CyclinE*@Nucleus map
  3. CDK2|​Tyr14_pho|​Tyr15_pho:​CyclinE*@Nucleus map
  4. CDK2|​Thr160_pho:​CyclinE*|​Thr380_pho@Nucleus map

In compartment: default

  1. CDK2:​CyclinE*@default map

  2. CDK2|​Y14/15_pho:​CyclinE*@default map
  3. (CDK2|​T160_pho:​CyclinE*)|​active@default map
  4. CDK2|​T160_pho|​Y14/15_pho:​CyclinE*@default map

Participates in reactions:
As Reactant or Product:

  1. CDK2|​Thr160_pho:​CyclinE*@Nucleus map + p107*@Nucleus map map CDK2|​Thr160_pho:​CyclinE*:​p107*@Nucleus map

  2. p130*|​pho@Nucleus map + CDK2|​Thr160_pho:​CyclinE*@Nucleus map map CDK2|​Thr160_pho:​CyclinE*:​p130*|​pho@Nucleus map
  3. CDK2:​CyclinE*@Nucleus map map CDK2|​Thr160_pho:​CyclinE*@Nucleus map
  4. CDK2:​CyclinE*@Nucleus map + p27KIP1*@Nucleus map map CDK2:​CyclinE*:​p27KIP1*@Nucleus map
  5. CDK2|​Thr160_pho:​CyclinE*@Nucleus map map CDK2|​Thr160_pho:​CyclinE*|​Thr380_pho@Nucleus map
  6. CDK2|​Thr160_pho:​CyclinE*|​Thr380_pho@Nucleus map map CyclinE*|​Thr380_pho@Nucleus map + CDK2|​Thr160_pho@Nucleus map
  7. CyclinE*@Nucleus map + CDK2@Nucleus map map CDK2:​CyclinE*@Nucleus map
  8. CDK2|​Thr160_pho:​CyclinE*@Nucleus map + p21CIP1*@Nucleus map map CDK2|​Thr160_pho:​CyclinE*:​p21CIP1*@Nucleus map
  9. CDK2:​CyclinE*@Nucleus map map CDK2|​Tyr14_pho|​Tyr15_pho:​CyclinE*@Nucleus map
  10. CIP1_KIP1*@default map + CDK2:​CyclinE*@default map map CDK2:​CIP1_KIP1*:​CyclinE*@default map
  11. CDK2:​CIP1_KIP1*:​CyclinE*@default map map CDK2:​CyclinE*@default map + CIP1_KIP1*@default map
  12. p107*@default map + CDK2:​CyclinE*@default map map CDK2:​CyclinE*:​p107*@default map
  13. CDK2:​CyclinE*@default map map CDK2|​Y14/15_pho:​CyclinE*@default map
  14. CDK2|​Y14/15_pho:​CyclinE*@default map map CDK2|​T160_pho|​Y14/15_pho:​CyclinE*@default map
  15. CyclinE*@default map + CDK2@default map map CDK2:​CyclinE*@default map
  16. CDK2|​T160_pho|​Y14/15_pho:​CyclinE*@default map map (CDK2|​T160_pho:​CyclinE*)|​active@default map
  17. CDK2:​CyclinE*@default map map CyclinE*@default map + CDK2@default map

As Catalyser:

  1. p27KIP1*@Nucleus map map p27KIP1*|​Thr187_pho@Nucleus map

  2. DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*@Nucleus map map DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*|​pho@Nucleus map
  3. BAF250*:​DP1*:​E2F1:​RB1|​pho|​pho@Nucleus map map DP1*:​E2F1:​RB1|​pho|​pho|​pho@Nucleus map + BAF250*|​pho@Nucleus map
  4. G1 phase@default map map S phase@default map
  5. E2F1:​RB1@default map map E2F1:​RB1|​pho@default map
  6. E2F4_5*:​p107*@default map map E2F4_5*:​p107*|​pho@default map
  7. CIP1_KIP1*@default map map degraded
  8. ORC4*@default map + ORC5*@default map + ORC6*@default map + ORC3*@default map + ORC2*@default map + ORC1*@default map map ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@default map
  9. MCM5@default map + MCM6@default map + MCM7@default map + MCM2@default map + MCM3@default map + MCM4@default map map MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@default map
  10. ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@default map + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@default map + CDT1@default map + CDC6@default map + CDC45@default map + POLA*@default map + PRIM*@default map + RPA1@Nucleus map + RPA2@Nucleus map + RPA3@Nucleus map map CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*:​RPA1:​RPA2:​RPA3@default map
  11. FOXO*@default map map FOXO*|​unk@default map

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