CDK2:CyclinA1*

Complex CDK2:CyclinA1* map


Complex composition:

  1. CDK2 map
  2. CyclinA1* map




CDK2|​T160_pho|​Y14/15_pho:​CyclinA1*@default

Identifiers
NAME:CDK2:CyclinA1*

Maps_Modules
 DNA repair  map  / S_CC_PHASE  map

Confidence
REF=0 FUNC=5

CDK2:​CyclinA1*@default

Identifiers
NAME:CDK2:CyclinA1*

Maps_Modules
 DNA repair  map  / S_CC_PHASE  map

Confidence
REF=0 FUNC=5

(CDK2|​T160_pho:​CyclinA1*)|​active@default

Identifiers
NAME:CDK2:CyclinA1*

Maps_Modules
 DNA repair  map  / S_CC_PHASE  map

References
d_re119( DNA repair  map ):
For inhibition of S-checkpoint by ATM:
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
PMID:19342888
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
PMID:16713580
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767
d_re355( DNA repair  map ):
For role of TIM1*/TIPIN in S-phase checkpoint, replication arrest, stalled replication forks stabilisation and DNA repair during S-phase:

Confidence
REF=5 FUNC=5

CDK2|​Y14/15_pho:​CyclinA1*@default

Identifiers
NAME:CDK2:CyclinA1*

Maps_Modules
 DNA repair  map  / S_CC_PHASE  map

Confidence
REF=0 FUNC=5


Modifications:
Participates in complexes:
In compartment: default
  1. CDK2:​CyclinA1*@default map

  2. CDK2|​Y14/15_pho:​CyclinA1*@default map
  3. (CDK2|​T160_pho:​CyclinA1*)|​active@default map
  4. CDK2|​T160_pho|​Y14/15_pho:​CyclinA1*@default map

Participates in reactions:
As Reactant or Product:

  1. CDK2@default map + CyclinA1*@default map map CDK2:​CyclinA1*@default map

  2. CIP1_KIP1*@default map + CDK2:​CyclinA1*@default map map CDK2:​CIP1_KIP1*:​CyclinA1*@default map
  3. CDK2:​CIP1_KIP1*:​CyclinA1*@default map map CDK2:​CyclinA1*@default map + CIP1_KIP1*@default map
  4. CDK2:​CyclinA1*@default map map CDK2@default map + CyclinA1*@default map
  5. p107*@default map + CDK2:​CyclinA1*@default map map CDK2:​CyclinA1*:​p107*@default map
  6. CDK2:​CyclinA1*@default map map CDK2|​Y14/15_pho:​CyclinA1*@default map
  7. CDK2|​Y14/15_pho:​CyclinA1*@default map map CDK2|​T160_pho|​Y14/15_pho:​CyclinA1*@default map
  8. CDK2|​T160_pho|​Y14/15_pho:​CyclinA1*@default map map (CDK2|​T160_pho:​CyclinA1*)|​active@default map

As Catalyser:

  1. S phase@default map map G2 phase@default map

  2. E2F1:​RB1@default map map E2F1:​RB1|​pho@default map
  3. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@default map map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@default map
  4. E2F4_5*:​p107*@default map map E2F4_5*:​p107*|​pho@default map
  5. ORC4*@default map + ORC5*@default map + ORC6*@default map + ORC3*@default map + ORC2*@default map + ORC1*@default map map ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@default map
  6. MCM5@default map + MCM6@default map + MCM7@default map + MCM2@default map + MCM3@default map + MCM4@default map map MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@default map
  7. ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@default map + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@default map + CDT1@default map + CDC6@default map + CDC45@default map + POLA*@default map + PRIM*@default map + RPA1@Nucleus map + RPA2@Nucleus map + RPA3@Nucleus map map CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*:​RPA1:​RPA2:​RPA3@default map

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