CDK1:CyclinB1*:GADD45A

Complex CDK1:CyclinB1*:GADD45A map


Complex composition:

  1. GADD45A map
  2. CDK1 map
  3. CyclinB1* map




CDK1:​CyclinB1*:​GADD45A@default

Identifiers
NAME:CDK1:CyclinB1*:GADD45A

Maps_Modules
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / NER  map

References
CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in response to DNA damage and causes G2/M arrest
PMID:12124778, PMID:19652693, PMID:15917306
d_re120( DNA repair  map ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141

Confidence
REF=5 FUNC=5


Modifications:
Participates in complexes:
In compartment: default
  1. CDK1:​CyclinB1*:​GADD45A@default map

Participates in reactions:
As Reactant or Product:

  1. CDK1:​CyclinB1*@default map + GADD45A@default map map CDK1:​CyclinB1*:​GADD45A@default map

As Catalyser:

  1. G2 phase@default map map M phase@default map

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