CDK1:CyclinB1*

Complex CDK1:CyclinB1* map


Complex composition:

  1. CDK1 map
  2. CyclinB1* map




CDK1|​T161_pho:​CyclinB1*@default

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
 DNA repair  map  / G2_CC_PHASE  map
 DNA repair  map  / M_CC_PHASE  map

References
d_re120( DNA repair  map ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141
d_re313( DNA repair  map ):
Activation by PLK phosphorylation at S191, S198
Activation by CDC2 phosphorylation at S214
PMID:17596790
d_re383:( DNA repair  map ) PMID:9892021

Confidence
REF=5 FUNC=5

CDK1|​Y14/15_pho|​T161_pho:​CyclinB1*@default

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
 DNA repair  map  / G2_CC_PHASE  map
 DNA repair  map  / M_CC_PHASE  map

References
d_re305:( DNA repair  map ) CAK phosphorylation of CDC2 is the first step toward complex activation

Confidence
REF=0 FUNC=5

CDK1:​CyclinB1*@Cytoplasm

Identifiers
NAME:CDK1:CyclinB1*

References
a_re498( Apoptosis  map ):
PMID:12792650
Direct phosphorylation of CASP9 by ERK2 sufficient to block CASP9 processing
in vitro, recombinant hCASP9 phosphorylated on T125 by cytosolic extract or ERK2
in Hela cells, interaction GST-CASP9 / ERK
in Hela or HEK293, CASP9 T125 phosphorylation by OA, consititutively active MEK1, EGF or TPA
PMID:17466630
CASP9 T125 phosphorylation by CCNB1:CDC2
comment: phosphorylation during mitosis, when nuclear envelope is broken down
PMID:19081073
CASP9 T125 phosphorylation by DYRK1A
PMID:19016842
PMID:19586613
CASP9 T125 phosphorylation by DYRK1A and p38
a_re669:( Apoptosis  map ) PMID:11069302

Confidence
REF=5 FUNC=5

CDK1|​Y14/15_pho:​CyclinB1*@default

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
 DNA repair  map  / G2_CC_PHASE  map
 DNA repair  map  / M_CC_PHASE  map

References
d_re273:( DNA repair  map ) Wee1 phosphorylation of CDC2 keeps the complex inactive
d_re305:( DNA repair  map ) CAK phosphorylation of CDC2 is the first step toward complex activation

Confidence
REF=0 FUNC=5

CDK1:​CyclinB1*@default

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
 DNA repair  map  / G2_CC_PHASE  map
 DNA repair  map  / M_CC_PHASE  map

References
d_re273:( DNA repair  map ) Wee1 phosphorylation of CDC2 keeps the complex inactive

Confidence
REF=0 FUNC=5

CDK1|​T161_pho|​pho:​CyclinB1*@default

Identifiers
NAME:CDK1:CyclinB1*

Maps_Modules
 DNA repair  map  / G2_CC_PHASE  map
 DNA repair  map  / M_CC_PHASE  map

Confidence
REF=0 FUNC=5


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. CDK1:​CyclinB1*@Cytoplasm map

In compartment: default

  1. CDK1:​CyclinB1*@default map

  2. CDK1|​T161_pho:​CyclinB1*@default map
  3. CDK1|​Y14/15_pho:​CyclinB1*@default map
  4. CDK1|​T161_pho|​pho:​CyclinB1*@default map
  5. CDK1|​Y14/15_pho|​T161_pho:​CyclinB1*@default map

Participates in reactions:
As Reactant or Product:

  1. CDK1@default map + CyclinB1*@default map map CDK1:​CyclinB1*@default map

  2. CDK1:​CyclinB1*@default map map CDK1|​Y14/15_pho:​CyclinB1*@default map
  3. CDK1|​Y14/15_pho|​T161_pho:​CyclinB1*@default map map CDK1|​T161_pho:​CyclinB1*@default map
  4. CDK1:​CyclinB1*@default map map CDK1@default map + CyclinB1*@default map
  5. CDK1|​Y14/15_pho:​CyclinB1*@default map map CDK1|​Y14/15_pho|​T161_pho:​CyclinB1*@default map
  6. CDK1:​CyclinB1*@default map + GADD45A@default map map CDK1:​CyclinB1*:​GADD45A@default map
  7. CDK1|​T161_pho:​CyclinB1*@default map map CDK1|​T161_pho|​pho:​CyclinB1*@default map
  8. CDK1|​Y14/15_pho|​T161_pho:​CyclinB1*@default map map CDK1|​Y14/15_pho:​CyclinB1*@default map
  9. CDK1|​T161_pho:​CyclinB1*@default map + 14-3-3*@default map map 14-3-3*:​CDK1|​T161_pho:​CyclinB1*@default map

As Catalyser:

  1. Caspase9*|​S196_unk|​S144_unk|​Y153_unk@Cytoplasm map map Caspase9*|​S196_unk|​T125_pho|​S144_unk|​Y153_unk@Cytoplasm map

  2. BIRC5@Cytoplasm map map BIRC5|​T34_pho@Cytoplasm map
  3. G2 phase@default map map M phase@default map
  4. WEE1|​CHEK1site_pho@Nucleus map map WEE1|​pho@default map
  5. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@default map map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@default map
  6. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@default map map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20|​pho:​CyclinA1*@default map
  7. CDC25A@default map map CDC25A|​S18_pho|​S116_pho|​active@default map
  8. CDC25B@default map map CDC25B|​S353_pho|​active@default map
  9. CDC25C@default map map CDC25C|​S191_pho|​S198_pho|​S214_pho|​active@default map
  10. PLK1@default map map PLK1|​pho|​active@default map
  11. EMI1*@default map map EMI1*|​pho@default map
  12. Securin*@default map map Securin*|​S165_pho@default map

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