Complex composition:
CDK1|Thr161_pho:CyclinB*@Nucleus
Identifiers
NAME:CDK1:CyclinB*
Maps_Modules
Cell cycle / APC
Cell cycle / CDC25
Cell cycle / CYCLINB
Cell cycle / P21CIP
Cell cycle / WEE
References
c_re216( Cell cycle ):
CDK activity stimulated by its CAK-complex phosphorylation.
PMID:12459251, PMID:12814430, PMID:7799941
c_re195( Cell cycle ):
phosphorylation and inactivation of Wee1 kinase
PMID:8515817, PMID:15070733, PMID:7681363 (yeast)
Cyclin B phosphorylates Myt1 in vitro
PMID:9268380
c_re255:( Cell cycle ) PMID:15840442
c_re258( Cell cycle ):
PMID:10548110
CYCLINB phosphorylates CDH1
PMID:11598127
c_re328:( Cell cycle ) PMID:15798220
c_re330( Cell cycle ):
Inactivated by phosphorylation by CHEK1 and CHEK2
PMID:12478465, PMID:12814430
Phosphorylation by CYCLINB-CDC2
PMID:11313986
CDK1:CyclinB*@Nucleus
Identifiers
NAME:CDK1:CyclinB*
Maps_Modules
Cell cycle / CYCLINB
References
c_re219( Cell cycle ):
dephosphorylation of CDC2 induce its activation
PMID:10373560, PMID:8348613, PMID:12814430
c_re230:( Cell cycle ) PMID:10373560, PMID:11063929
c_re233( Cell cycle ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430, PMID:1828290
c_re216( Cell cycle ):
CDK activity stimulated by its CAK-complex phosphorylation.
PMID:12459251, PMID:12814430, PMID:7799941
c_re232( Cell cycle ):
CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin.
PMID:12814430
WEE1 allows CDC2 to stay in an inactive state after its translocation in late G2
PMID:10373560, PMID:8348613, PMID:9001210, PMID:15037762
CDK1|Tyr15_pho:CyclinB*@Nucleus
Identifiers
NAME:CDK1:CyclinB*
Maps_Modules
Cell cycle / CYCLINB
References
c_re232( Cell cycle ):
CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin.
PMID:12814430
WEE1 allows CDC2 to stay in an inactive state after its translocation in late G2
PMID:10373560, PMID:8348613, PMID:9001210, PMID:15037762
c_re234:( Cell cycle ) PMID:10373560, PMID:10395539, PMID:11063929
c_re241( Cell cycle ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430
c_re233( Cell cycle ):
PMID:10373560, PMID:8348613, PMID:12814430, PMID:1828290
c_re235( Cell cycle ):
PMID:10373560
The NES (Nuclear Export Signal) of cyclin B induces its active export. This export seems to be done via a CRM1 complex and could need the GTPaseRan/TC4.
PMID:9679058, PMID:9670027, PMID:9679058
CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Nucleus
Identifiers
NAME:CDK1:CyclinB*
Maps_Modules
Cell cycle / CYCLINB
References
c_re212:( Cell cycle ) PMID:10373560 , PMID:10395539, PMID:11063929
c_re218( Cell cycle ):
CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin.
PMID:12814430
WEE1 allows CDC2 to stay in an inactive state after its translocation during G2.
PMID:10373560, PMID:8348613, PMID:9001210, PMID:1384126, PMID:15037762
c_re217( Cell cycle ):
dephosphorylation of CDC2 induce its activation
PMID:10373560, PMID:8348613, PMID:12814430
c_re220( Cell cycle ):
PMID:10373560
The NES (nuclear export signal) of the cyclin B allows its active export. Export via the CRM1 complex, seems to need GTPaseRan/TC4
PMID:9679058, PMID:9670027, PMID:9679058
c_re241( Cell cycle ):
Dephosphorylation of CDC2 induces its activation.
CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Cytoplasm
Identifiers
NAME:CDK1:CyclinB*
Maps_Modules
Cell cycle / CYCLINB
References
c_re220( Cell cycle ):
PMID:10373560
The NES (nuclear export signal) of the cyclin B allows its active export. Export via the CRM1 complex, seems to need GTPaseRan/TC4
PMID:9679058, PMID:9670027, PMID:9679058
c_re224( Cell cycle ):
Phosphorylation only when CDC2 is bound to the cyclin D.
PMID:10373560, PMID:9001210, PMID:12814430
c_re212:( Cell cycle ) PMID:10373560 , PMID:10395539, PMID:11063929
c_re225( Cell cycle ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430
CDK1|Thr14_pho:CyclinB*@Cytoplasm
Identifiers
NAME:CDK1:CyclinB*
Maps_Modules
Cell cycle / CYCLINB
References
c_re225( Cell cycle ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430
c_re226( Cell cycle ):
Phosphorylation only when CDC2 is bound to the cyclin B
PMID:10373560, PMID:9001210, PMID:12814430, PMID:9268380
c_re229( Cell cycle ):
The NES (Nuclear Export Signal) of cyclin B induces its active export. This export seems to be done via a CRM1 complex and would need the GTPaseRan/TC4
PMID:9679058, PMID:9670027, PMID:9679058, PMID:10373560
c_re224( Cell cycle ):
Phosphorylation only when CDC2 is bound to the cyclin D.
PMID:10373560, PMID:9001210, PMID:12814430
c_re228:( Cell cycle ) PMID:10373560, PMID:11063929
CDK1:CyclinB*@Cytoplasm
Identifiers
NAME:CDK1:CyclinB*
Maps_Modules
Cell cycle / CYCLINB
References
c_re221( Cell cycle ):
Cytoplasmic binding
PMID:9001210, PMID:1717476
c_re227( Cell cycle ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430
c_re237( Cell cycle ):
PMID:10373560, PMID:8348613, PMID:12814430, PMID:10827953, PMID:8440392, PMID:15456846, PMID:12524548, PMID:8119945, PMID:8428594, PMID:15107615, PMID:12411508
c_re226( Cell cycle ):
Phosphorylation only when CDC2 is bound to the cyclin B
PMID:10373560, PMID:9001210, PMID:12814430, PMID:9268380
c_re230:( Cell cycle ) PMID:10373560, PMID:11063929
c_re238( Cell cycle ):
Phosphorylation only when CDC2 is bound to the cyclin D.
PMID:10373560, PMID:9001210, PMID:12814430
CDK1|Tyr15_pho:CyclinB*@Cytoplasm
Identifiers
NAME:CDK1:CyclinB*
Maps_Modules
Cell cycle / CYCLINB
References
c_re235( Cell cycle ):
PMID:10373560
The NES (Nuclear Export Signal) of cyclin B induces its active export. This export seems to be done via a CRM1 complex and could need the GTPaseRan/TC4.
PMID:9679058, PMID:9670027, PMID:9679058
c_re238( Cell cycle ):
Phosphorylation only when CDC2 is bound to the cyclin D.
PMID:10373560, PMID:9001210, PMID:12814430
c_re239( Cell cycle ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430
c_re234:( Cell cycle ) PMID:10373560, PMID:10395539, PMID:11063929
c_re237( Cell cycle ):
PMID:10373560, PMID:8348613, PMID:12814430, PMID:10827953, PMID:8440392, PMID:15456846, PMID:12524548, PMID:8119945, PMID:8428594, PMID:15107615, PMID:12411508
CDK1|Thr14_pho:CyclinB*@Nucleus
Identifiers
NAME:CDK1:CyclinB*
Maps_Modules
Cell cycle / CYCLINB
References
c_re217( Cell cycle ):
dephosphorylation of CDC2 induce its activation
PMID:10373560, PMID:8348613, PMID:12814430
c_re228:( Cell cycle ) PMID:10373560, PMID:11063929
c_re218( Cell cycle ):
CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin.
PMID:12814430
WEE1 allows CDC2 to stay in an inactive state after its translocation during G2.
PMID:10373560, PMID:8348613, PMID:9001210, PMID:1384126, PMID:15037762
c_re229( Cell cycle ):
The NES (Nuclear Export Signal) of cyclin B induces its active export. This export seems to be done via a CRM1 complex and would need the GTPaseRan/TC4
PMID:9679058, PMID:9670027, PMID:9679058, PMID:10373560
Modifications:
Participates in complexes:
In compartment: Cytoplasm
- CDK1:CyclinB*@Cytoplasm
- CDK1|Thr14_pho:CyclinB*@Cytoplasm
- CDK1|Tyr15_pho:CyclinB*@Cytoplasm
- CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Cytoplasm
In compartment: Nucleus
- CDK1:CyclinB*@Nucleus
- CDK1|Thr14_pho:CyclinB*@Nucleus
- CDK1|Tyr15_pho:CyclinB*@Nucleus
- CDK1|Thr161_pho:CyclinB*@Nucleus
- CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Nucleus
Participates in reactions:
As Reactant or Product:
- CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Cytoplasm
→
CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Nucleus
- CDK1:CyclinB*@Nucleus
→
CDK1|Thr161_pho:CyclinB*@Nucleus
- CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Nucleus
→
CDK1|Thr14_pho:CyclinB*@Nucleus
- CDK1|Thr14_pho:CyclinB*@Nucleus
→
CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Nucleus
- CDK1|Thr14_pho:CyclinB*@Nucleus
→
CDK1:CyclinB*@Nucleus
- CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Nucleus
→
CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Cytoplasm
- CDK1@Cytoplasm
+ CyclinB*@Cytoplasm
→
CDK1:CyclinB*@Cytoplasm
- CDK1|Thr14_pho:CyclinB*@Cytoplasm
→
CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Cytoplasm
- CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Cytoplasm
→
CDK1|Thr14_pho:CyclinB*@Cytoplasm
- CDK1:CyclinB*@Cytoplasm
→
CDK1|Thr14_pho:CyclinB*@Cytoplasm
- CDK1|Thr14_pho:CyclinB*@Cytoplasm
→
CDK1:CyclinB*@Cytoplasm
- CDK1|Thr14_pho:CyclinB*@Cytoplasm
→
CDK1|Thr14_pho:CyclinB*@Nucleus
- CDK1|Thr14_pho:CyclinB*@Nucleus
→
CDK1|Thr14_pho:CyclinB*@Cytoplasm
- CDK1:CyclinB*@Cytoplasm
→
CDK1:CyclinB*@Nucleus
- CDK1:CyclinB*@Nucleus
→
CDK1|Tyr15_pho:CyclinB*@Nucleus
- CDK1|Tyr15_pho:CyclinB*@Nucleus
→
CDK1:CyclinB*@Nucleus
- CDK1|Tyr15_pho:CyclinB*@Cytoplasm
→
CDK1|Tyr15_pho:CyclinB*@Nucleus
- CDK1|Tyr15_pho:CyclinB*@Nucleus
→
CDK1|Tyr15_pho:CyclinB*@Cytoplasm
- CDK1|Tyr15_pho:CyclinB*@Cytoplasm
→
CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Cytoplasm
- CDK1|Tyr15_pho:CyclinB*@Cytoplasm
→
CDK1:CyclinB*@Cytoplasm
- CDK1:CyclinB*@Cytoplasm
→
CDK1|Tyr15_pho:CyclinB*@Cytoplasm
- CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Cytoplasm
→
CDK1|Tyr15_pho:CyclinB*@Cytoplasm
- CDK1|Tyr15_pho|Thr14_pho:CyclinB*@Nucleus
→
CDK1|Tyr15_pho:CyclinB*@Nucleus
- CDK1|Thr161_pho:CyclinB*@Nucleus
→
CyclinB*@Nucleus
+ CDK1|Thr161_pho@Nucleus
- CDK1|Thr161_pho:CyclinB*@Nucleus
+ p21CIP1*|Thr57_pho@Nucleus
→
CDK1|Thr161_pho:CyclinB*:p21CIP1*@Nucleus
As Catalyser: