CDK1:CyclinB*

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Complex CDK1:CyclinB* map

Complex composition:

  1. CyclinB* map
  2. CDK1 map



CDK1|​Thr161_pho:​CyclinB*@Nucleus

Identifiers
NAME:CDK1:CyclinB*

Maps_Modules
 Cell cycle  map  / APC  map
 Cell cycle  map  / CDC25  map
 Cell cycle  map  / CYCLINB  map
 Cell cycle  map  / P21CIP  map
 Cell cycle  map  / WEE  map

References
c_re216( Cell cycle  map ):
CDK activity stimulated by its CAK-complex phosphorylation.
PMID:12459251, PMID:12814430, PMID:7799941
c_re195( Cell cycle  map ):
phosphorylation and inactivation of Wee1 kinase
PMID:8515817, PMID:15070733, PMID:7681363 (yeast)
Cyclin B phosphorylates Myt1 in vitro
PMID:9268380
c_re255:( Cell cycle  map ) PMID:15840442
c_re258( Cell cycle  map ):
PMID:10548110
CYCLINB phosphorylates CDH1
PMID:11598127
c_re328:( Cell cycle  map ) PMID:15798220
c_re330( Cell cycle  map ):
Inactivated by phosphorylation by CHEK1 and CHEK2
PMID:12478465, PMID:12814430
Phosphorylation by CYCLINB-CDC2
PMID:11313986

CDK1:​CyclinB*@Nucleus

Identifiers
NAME:CDK1:CyclinB*

Maps_Modules
 Cell cycle  map  / CYCLINB  map

References
c_re219( Cell cycle  map ):
dephosphorylation of CDC2 induce its activation
PMID:10373560, PMID:8348613, PMID:12814430
c_re230:( Cell cycle  map ) PMID:10373560, PMID:11063929
c_re233( Cell cycle  map ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430, PMID:1828290
c_re216( Cell cycle  map ):
CDK activity stimulated by its CAK-complex phosphorylation.
PMID:12459251, PMID:12814430, PMID:7799941
c_re232( Cell cycle  map ):
CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin.
PMID:12814430
WEE1 allows CDC2 to stay in an inactive state after its translocation in late G2
PMID:10373560, PMID:8348613, PMID:9001210, PMID:15037762

CDK1|​Tyr15_pho:​CyclinB*@Nucleus

Identifiers
NAME:CDK1:CyclinB*

Maps_Modules
 Cell cycle  map  / CYCLINB  map

References
c_re232( Cell cycle  map ):
CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin.
PMID:12814430
WEE1 allows CDC2 to stay in an inactive state after its translocation in late G2
PMID:10373560, PMID:8348613, PMID:9001210, PMID:15037762
c_re234:( Cell cycle  map ) PMID:10373560, PMID:10395539, PMID:11063929
c_re241( Cell cycle  map ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430
c_re233( Cell cycle  map ):
PMID:10373560, PMID:8348613, PMID:12814430, PMID:1828290
c_re235( Cell cycle  map ):
PMID:10373560
The NES (Nuclear Export Signal) of cyclin B induces its active export. This export seems to be done via a CRM1 complex and could need the GTPaseRan/TC4.
PMID:9679058, PMID:9670027, PMID:9679058

CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus

Identifiers
NAME:CDK1:CyclinB*

Maps_Modules
 Cell cycle  map  / CYCLINB  map

References
c_re212:( Cell cycle  map ) PMID:10373560 , PMID:10395539, PMID:11063929
c_re218( Cell cycle  map ):
CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin.
PMID:12814430
WEE1 allows CDC2 to stay in an inactive state after its translocation during G2.
PMID:10373560, PMID:8348613, PMID:9001210, PMID:1384126, PMID:15037762
c_re217( Cell cycle  map ):
dephosphorylation of CDC2 induce its activation
PMID:10373560, PMID:8348613, PMID:12814430
c_re220( Cell cycle  map ):
PMID:10373560
The NES (nuclear export signal) of the cyclin B allows its active export. Export via the CRM1 complex, seems to need GTPaseRan/TC4
PMID:9679058, PMID:9670027, PMID:9679058
c_re241( Cell cycle  map ):
Dephosphorylation of CDC2 induces its activation.

CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm

Identifiers
NAME:CDK1:CyclinB*

Maps_Modules
 Cell cycle  map  / CYCLINB  map

References
c_re220( Cell cycle  map ):
PMID:10373560
The NES (nuclear export signal) of the cyclin B allows its active export. Export via the CRM1 complex, seems to need GTPaseRan/TC4
PMID:9679058, PMID:9670027, PMID:9679058
c_re224( Cell cycle  map ):
Phosphorylation only when CDC2 is bound to the cyclin D.
PMID:10373560, PMID:9001210, PMID:12814430
c_re212:( Cell cycle  map ) PMID:10373560 , PMID:10395539, PMID:11063929
c_re225( Cell cycle  map ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430

CDK1|​Thr14_pho:​CyclinB*@Cytoplasm

Identifiers
NAME:CDK1:CyclinB*

Maps_Modules
 Cell cycle  map  / CYCLINB  map

References
c_re225( Cell cycle  map ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430
c_re226( Cell cycle  map ):
Phosphorylation only when CDC2 is bound to the cyclin B
PMID:10373560, PMID:9001210, PMID:12814430, PMID:9268380
c_re229( Cell cycle  map ):
The NES (Nuclear Export Signal) of cyclin B induces its active export. This export seems to be done via a CRM1 complex and would need the GTPaseRan/TC4
PMID:9679058, PMID:9670027, PMID:9679058, PMID:10373560
c_re224( Cell cycle  map ):
Phosphorylation only when CDC2 is bound to the cyclin D.
PMID:10373560, PMID:9001210, PMID:12814430
c_re228:( Cell cycle  map ) PMID:10373560, PMID:11063929

CDK1:​CyclinB*@Cytoplasm

Identifiers
NAME:CDK1:CyclinB*

Maps_Modules
 Cell cycle  map  / CYCLINB  map

References
c_re221( Cell cycle  map ):
Cytoplasmic binding
PMID:9001210, PMID:1717476
c_re227( Cell cycle  map ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430
c_re237( Cell cycle  map ):
PMID:10373560, PMID:8348613, PMID:12814430, PMID:10827953, PMID:8440392, PMID:15456846, PMID:12524548, PMID:8119945, PMID:8428594, PMID:15107615, PMID:12411508
c_re226( Cell cycle  map ):
Phosphorylation only when CDC2 is bound to the cyclin B
PMID:10373560, PMID:9001210, PMID:12814430, PMID:9268380
c_re230:( Cell cycle  map ) PMID:10373560, PMID:11063929
c_re238( Cell cycle  map ):
Phosphorylation only when CDC2 is bound to the cyclin D.
PMID:10373560, PMID:9001210, PMID:12814430

CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm

Identifiers
NAME:CDK1:CyclinB*

Maps_Modules
 Cell cycle  map  / CYCLINB  map

References
c_re235( Cell cycle  map ):
PMID:10373560
The NES (Nuclear Export Signal) of cyclin B induces its active export. This export seems to be done via a CRM1 complex and could need the GTPaseRan/TC4.
PMID:9679058, PMID:9670027, PMID:9679058
c_re238( Cell cycle  map ):
Phosphorylation only when CDC2 is bound to the cyclin D.
PMID:10373560, PMID:9001210, PMID:12814430
c_re239( Cell cycle  map ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430
c_re234:( Cell cycle  map ) PMID:10373560, PMID:10395539, PMID:11063929
c_re237( Cell cycle  map ):
PMID:10373560, PMID:8348613, PMID:12814430, PMID:10827953, PMID:8440392, PMID:15456846, PMID:12524548, PMID:8119945, PMID:8428594, PMID:15107615, PMID:12411508

CDK1|​Thr14_pho:​CyclinB*@Nucleus

Identifiers
NAME:CDK1:CyclinB*

Maps_Modules
 Cell cycle  map  / CYCLINB  map

References
c_re217( Cell cycle  map ):
dephosphorylation of CDC2 induce its activation
PMID:10373560, PMID:8348613, PMID:12814430
c_re228:( Cell cycle  map ) PMID:10373560, PMID:11063929
c_re218( Cell cycle  map ):
CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin.
PMID:12814430
WEE1 allows CDC2 to stay in an inactive state after its translocation during G2.
PMID:10373560, PMID:8348613, PMID:9001210, PMID:1384126, PMID:15037762
c_re229( Cell cycle  map ):
The NES (Nuclear Export Signal) of cyclin B induces its active export. This export seems to be done via a CRM1 complex and would need the GTPaseRan/TC4
PMID:9679058, PMID:9670027, PMID:9679058, PMID:10373560

Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. CDK1:​CyclinB*@Cytoplasm map

  2. CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map
  3. CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map
  4. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map

In compartment: Nucleus

  1. CDK1:​CyclinB*@Nucleus map

  2. CDK1|​Thr14_pho:​CyclinB*@Nucleus map
  3. CDK1|​Tyr15_pho:​CyclinB*@Nucleus map
  4. CDK1|​Thr161_pho:​CyclinB*@Nucleus map
  5. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map → map CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map

  2. CDK1:​CyclinB*@Nucleus map → map CDK1|​Thr161_pho:​CyclinB*@Nucleus map
  3. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map → map CDK1|​Thr14_pho:​CyclinB*@Nucleus map
  4. CDK1|​Thr14_pho:​CyclinB*@Nucleus map → map CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map
  5. CDK1|​Thr14_pho:​CyclinB*@Nucleus map → map CDK1:​CyclinB*@Nucleus map
  6. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map → map CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map
  7. CDK1@Cytoplasm map + CyclinB*@Cytoplasm map → map CDK1:​CyclinB*@Cytoplasm map
  8. CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map → map CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map
  9. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map → map CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map
  10. CDK1:​CyclinB*@Cytoplasm map → map CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map
  11. CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map → map CDK1:​CyclinB*@Cytoplasm map
  12. CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map → map CDK1|​Thr14_pho:​CyclinB*@Nucleus map
  13. CDK1|​Thr14_pho:​CyclinB*@Nucleus map → map CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map
  14. CDK1:​CyclinB*@Cytoplasm map → map CDK1:​CyclinB*@Nucleus map
  15. CDK1:​CyclinB*@Nucleus map → map CDK1|​Tyr15_pho:​CyclinB*@Nucleus map
  16. CDK1|​Tyr15_pho:​CyclinB*@Nucleus map → map CDK1:​CyclinB*@Nucleus map
  17. CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map → map CDK1|​Tyr15_pho:​CyclinB*@Nucleus map
  18. CDK1|​Tyr15_pho:​CyclinB*@Nucleus map → map CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map
  19. CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map → map CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map
  20. CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map → map CDK1:​CyclinB*@Cytoplasm map
  21. CDK1:​CyclinB*@Cytoplasm map → map CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map
  22. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map → map CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map
  23. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map → map CDK1|​Tyr15_pho:​CyclinB*@Nucleus map
  24. CDK1|​Thr161_pho:​CyclinB*@Nucleus map → map CyclinB*@Nucleus map + CDK1|​Thr161_pho@Nucleus map
  25. CDK1|​Thr161_pho:​CyclinB*@Nucleus map + p21CIP1*|​Thr57_pho@Nucleus map → map CDK1|​Thr161_pho:​CyclinB*:​p21CIP1*@Nucleus map

As Catalyser:

  1. WEE1@Nucleus map → map WEE1|​pho@Nucleus map

  2. CDC20@Nucleus map → map CDC20|​pho@Nucleus map
  3. FZR1@Nucleus map → map FZR1|​pho@Nucleus map
  4. CDC25C@Nucleus map → map CDC25C|​pho@Nucleus map

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