CDK1

Protein CDK1 map

Identifiers
cyclin-dependent kinase 1
HUGO:CDK1 HGNC:1722 ENTREZ:983 UNIPROT:P06493 GENECARDS:CDK1 REACTOME:86981 KEGG:983 ATLASONC:GC_CDK1 WIKI:CDK1

Maps_Modules
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MOMP_REGULATION  map
 DNA repair  map  / S_CC_PHASE  map
 DNA repair  map  / G2_CC_PHASE  map
 DNA repair  map  / M_CC_PHASE  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 Cell cycle  map  / CYCLINB  map
 Survival  map  / PI3K_AKT_MTOR  map

References
synonym:CDC2
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786
PMID:14551205
PMID:18414028

CDK1@Cytoplasm

References
a_re630( Apoptosis  map ):
PMID:12049737
in vitro with recombinant murine proteines
in COS cells with ectopic expression of BAD
in rat granule neurons upon suppression of neuronal activity, cdc2 is induced, phosphorylates BAD S128
in rat neurones expressing ectopic proteins, cdc2 induced apoptosis is inhibited by a BAD S118 mutant
in vitro, AKT mediated BAD S136 phosphorylation is not blocked by prior cdc2 mediated BAD S128 phosphorylations
BAD S128 phosphorylation inhibits BAD phospho S136 : 14-3-3 interaction

CDK1@Nucleus

References
c_re322:( Cell cycle  map ) PMID:11355576

CDK1|​Thr161_pho@Nucleus

References
c_re322:( Cell cycle  map ) PMID:11355576


Modifications:
In compartment: Cytoplasm
  1. CDK1@Cytoplasm map

In compartment: Nucleus

  1. CDK1@Nucleus map

  2. CDK1|​Thr161_pho@Nucleus map

In compartment: default

  1. CDK1@default map

Participates in complexes:
In compartment: Cytoplasm

  1. CDK1:​CyclinB1*@Cytoplasm map

  2. CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map
  3. CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map
  4. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map

In compartment: Nucleus

  1. CDK1:​CyclinB*@Nucleus map

  2. CDK1|​Thr14_pho:​CyclinB*@Nucleus map
  3. CDK1|​Tyr15_pho:​CyclinB*@Nucleus map
  4. CDK1|​Thr161_pho:​CyclinB*@Nucleus map
  5. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map
  6. CDK1|​Thr161_pho:​CyclinB*:​p21CIP1*@Nucleus map

In compartment: default

  1. CDK1:​CyclinA1*@default map

  2. CDK1:​CyclinB1*@default map
  3. CDK1|​T161_pho:​CyclinB1*@default map
  4. CDK1|​Y14/15_pho:​CyclinA1*@default map
  5. CDK1|​Y14/15_pho:​CyclinB1*@default map
  6. CDK1|​T161_pho|​pho:​CyclinB1*@default map
  7. CDK1|​Y14/15_pho|​T161_pho:​CyclinB1*@default map
  8. (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@default map
  9. CDK1:​CyclinB1*:​GADD45A@default map
  10. 14-3-3*:​CDK1|​T161_pho:​CyclinB1*@default map

Participates in reactions:
As Reactant or Product:

  1. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map map CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map

  2. CDK1:​CyclinB*@Nucleus map map CDK1|​Thr161_pho:​CyclinB*@Nucleus map
  3. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map map CDK1|​Thr14_pho:​CyclinB*@Nucleus map
  4. CDK1|​Thr14_pho:​CyclinB*@Nucleus map map CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map
  5. CDK1|​Thr14_pho:​CyclinB*@Nucleus map map CDK1:​CyclinB*@Nucleus map
  6. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map map CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map
  7. CDK1@Cytoplasm map + CyclinB*@Cytoplasm map map c_s767
  8. CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map map CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map
  9. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map map CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map
  10. c_s767 map CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map
  11. CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map map c_s767
  12. CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map map CDK1|​Thr14_pho:​CyclinB*@Nucleus map
  13. CDK1|​Thr14_pho:​CyclinB*@Nucleus map map CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map
  14. c_s767 map CDK1:​CyclinB*@Nucleus map
  15. CDK1:​CyclinB*@Nucleus map map CDK1|​Tyr15_pho:​CyclinB*@Nucleus map
  16. CDK1|​Tyr15_pho:​CyclinB*@Nucleus map map CDK1:​CyclinB*@Nucleus map
  17. CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map map CDK1|​Tyr15_pho:​CyclinB*@Nucleus map
  18. CDK1|​Tyr15_pho:​CyclinB*@Nucleus map map CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map
  19. CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map map CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map
  20. CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map map c_s767
  21. c_s767 map CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map
  22. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map map CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map
  23. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map map CDK1|​Tyr15_pho:​CyclinB*@Nucleus map
  24. CDK1|​Thr161_pho:​CyclinB*@Nucleus map map CyclinB*@Nucleus map + CDK1|​Thr161_pho@Nucleus map
  25. CDK1|​Thr161_pho@Nucleus map map CDK1@Nucleus map
  26. CDK1|​Thr161_pho:​CyclinB*@Nucleus map + p21CIP1*|​Thr57_pho@Nucleus map map CDK1|​Thr161_pho:​CyclinB*:​p21CIP1*@Nucleus map
  27. CDK1@default map + CyclinB1*@default map map CDK1:​CyclinB1*@default map
  28. CDK1:​CyclinB1*@default map map CDK1|​Y14/15_pho:​CyclinB1*@default map
  29. CDK1|​Y14/15_pho|​T161_pho:​CyclinB1*@default map map CDK1|​T161_pho:​CyclinB1*@default map
  30. CDK1:​CyclinB1*@default map map CDK1@default map + CyclinB1*@default map
  31. CDK1|​Y14/15_pho:​CyclinB1*@default map map CDK1|​Y14/15_pho|​T161_pho:​CyclinB1*@default map
  32. CDK1:​CyclinB1*@default map + GADD45A@default map map CDK1:​CyclinB1*:​GADD45A@default map
  33. CyclinA1*@default map + CDK1@default map map CDK1:​CyclinA1*@default map
  34. CDK1:​CyclinA1*@default map map CDK1|​Y14/15_pho:​CyclinA1*@default map
  35. CDK1|​Y14/15_pho:​CyclinA1*@default map map (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@default map
  36. (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@default map map (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@default map
  37. (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@default map map (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@default map
  38. CDK1|​T161_pho:​CyclinB1*@default map map CDK1|​T161_pho|​pho:​CyclinB1*@default map
  39. CDK1|​Y14/15_pho|​T161_pho:​CyclinB1*@default map map CDK1|​Y14/15_pho:​CyclinB1*@default map
  40. CDK1|​T161_pho:​CyclinB1*@default map + 14-3-3*@default map map 14-3-3*:​CDK1|​T161_pho:​CyclinB1*@default map

As Catalyser:

  1. Caspase9*|​S196_unk|​S144_unk|​Y153_unk@Cytoplasm map map Caspase9*|​S196_unk|​T125_pho|​S144_unk|​Y153_unk@Cytoplasm map

  2. BAD|​unk@Cytoplasm map map BAD|​S91_pho|​unk@Cytoplasm map
  3. BIRC5@Cytoplasm map map BIRC5|​T34_pho@Cytoplasm map
  4. WEE1@Nucleus map map WEE1|​pho@Nucleus map
  5. CDC20@Nucleus map map CDC20|​pho@Nucleus map
  6. FZR1@Nucleus map map FZR1|​pho@Nucleus map
  7. CDC25C@Nucleus map map CDC25C|​pho@Nucleus map
  8. S phase@default map map G2 phase@default map
  9. G2 phase@default map map M phase@default map
  10. TP53BP1@default map map TP53BP1|​pho@default map
  11. E2F1:​RB1@default map map E2F1:​RB1|​pho@default map
  12. WEE1|​CHEK1site_pho@Nucleus map map WEE1|​pho@default map
  13. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@default map map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@default map
  14. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@default map map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20|​pho:​CyclinA1*@default map
  15. CDC25A@default map map CDC25A|​S18_pho|​S116_pho|​active@default map
  16. CDC25B@default map map CDC25B|​S353_pho|​active@default map
  17. CDC25C@default map map CDC25C|​S191_pho|​S198_pho|​S214_pho|​active@default map
  18. ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@default map + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@default map + CDT1@default map + CDC6@default map + CDC45@default map + POLA*@default map + PRIM*@default map + RPA1@Nucleus map + RPA2@Nucleus map + RPA3@Nucleus map map CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*:​RPA1:​RPA2:​RPA3@default map
  19. PLK1@default map map PLK1|​pho|​active@default map
  20. EMI1*@default map map EMI1*|​pho@default map
  21. Securin*@default map map Securin*|​S165_pho@default map
  22. TSC1@Endosome Membrane map map TSC1|​T417_pho|​S584_pho|​T1047_pho@Endosome Membrane map

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