CDC42:GTP

Complex CDC42:GTP map


Complex composition:

  1. GTP map
  2. CDC42 map




CDC42:​GTP@Cytoplasm

Identifiers
NAME:CDC42:GTP

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / TIGHT_JUNCTIONS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
e_re844( EMT  map ):
PMID:10816584
PMID:17045588
CDC42SE1 (SPEC1) binds to CDC42 and supresses CDC42-induced JNK activation and cytoskeleton remodeling.
PMID:9113980
RhoGDI (so-called ARHGDIA) and GDIG4 (so-called ARHGDIB) are two known GDIs for the Rho-subfamily of GTPases.
ARHGDIG is about 50 percent identical to ARHGDIA and ARHGDIB. ARHGFIG binds to CDC42 and RhoA with less affinity compared with ARHGDIA and does not bind with Rac1, Rac2, or Ras.
ARHGDIG functions as a GDI for CDC42 but with about 20 times less efficiency than ARHGDIA.
PMID:9490022
ARHGDIA,B,G are CDC42_GDIs
e_re840( EMT  map ):
PMID:15713627
Spatially distinct binding of Cdc42 to PAK1 and N-WASP
e_re855( EMT  map ):
PMID:10873802
PARD6 contains a PDZ domain and a Cdc42/Rac interactive binding (CRIB) motif
PARD6 interacts with Rac1 and Cdc42 in a GTP-dependent manner
PMID:10934475
PARD6 binds to Cdc42/Rac1 GTPases
PMID:10954424
PARD6 is a binding partner for the Rho GTPases Cdc42 and Rac1
e_re858( EMT  map ):
PMID:8625410
PMID:16293614
PMID:10467124
PMID:10511705
CDC42 induces actin cytoskeleton changes by activating WASP and N-WASP.
WASP and N-WASP binds to ARP2/3 and this lieads to actin cytoskeletal polymerization and filopodia formation.
PMID:10940259
CDC42 initiates WASP/Arp2_3 nucleation of actin.
e_re864( EMT  map ):
CDC42 promotes cytoskeleton remodeling by binding to CDC42EPs (CDC42EP2 and CDC42EP3)
PMID:10490598
PMID:11035016
e_re872( EMT  map ):
PMID:17161586
CDC42 can activate JNL pathway aslo by binding and stimulation of MAP3K11 (MLK3).

Confidence
REF=5 FUNC=0


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. CDC42:​GTP@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. CDC42:​GDP@Cytoplasm map map CDC42:​GTP@Cytoplasm map

  2. CDC42:​GTP@Cytoplasm map map CDC42:​GDP@Cytoplasm map
  3. PAR6*@Cytoplasm map + CDC42:​GTP@Cytoplasm map map CDC42:​GTP:​PAR6*@Cytoplasm map
  4. CDC42:​GTP@Cytoplasm map + CDC42EP*@Cytoplasm map map CDC42:​CDC42EP*@Cytoplasm map

As Catalyser:

  1. PAK1@Cytoplasm map map PAK1@Cytoplasm map

  2. PAK2@Cytoplasm map map PAK2@Cytoplasm map
  3. PAK3@Cytoplasm map map PAK3@Cytoplasm map
  4. PAK4@Cytoplasm map map PAK4@Cytoplasm map
  5. CDC42BPA@Cytoplasm map map CDC42BPA@Cytoplasm map
  6. WASP_NWASP*@Cytoplasm map map WASP_NWASP*@Cytoplasm map
  7. MAP3K11@Cytoplasm map map MAP3K11@Cytoplasm map

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