CDC42BPA

Protein CDC42BPA map

Identifiers
CDC42 binding protein kinase alpha (DMPK-like)
HUGO:CDC42BPA HGNC:1737 ENTREZ:8476 UNIPROT:Q5VT25 GENECARDS:CDC42BPA KEGG:8476 ATLASONC:GC_CDC42BPA WIKI:CDC42BPA

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

CDC42BPA@Cytoplasm

References
e_re846( EMT  map ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.


Modifications:
In compartment: Cytoplasm
  1. CDC42BPA@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. CDC42BPA@Cytoplasm map map CDC42BPA@Cytoplasm map

    As Catalyser:

    1. LIMK1@Cytoplasm map map LIMK1|​pho|​active@Nucleus map

    2. LIMK2@Cytoplasm map map LIMK2|​pho|​active@Cytoplasm map

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