CDC25C

Protein CDC25C map

Identifiers
cell division cycle 25 homolog C (S. pombe)
HUGO:CDC25C HGNC:1727 ENTREZ:995 UNIPROT:P30307 GENECARDS:CDC25C REACTOME:95494 KEGG:995 ATLASONC:GC_CDC25C WIKI:CDC25C

Maps_Modules
 DNA repair  map  / G2_CC_PHASE  map
 Cell cycle  map  / CDC25  map

References
PMID:1075565, PMID:18073536, PMID:18786381, PMID:17568790, PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786
Inactivated by CHEK1 and CHEK2
PMID:12478465

CDC25C@default

References
d_re63:( DNA repair  map ) kegg cell cycle
d_re313( DNA repair  map ):
Activation by PLK phosphorylation at S191, S198
Activation by CDC2 phosphorylation at S214
PMID:17596790
d_re316( DNA repair  map ):
Phosphorylation of CDC25A, B or C by CHEK1 and CHEK2 inactivates CDC25, prevents activating de-phosphorylation of CDKs by CDC25 A, B, C
and stops cell cycle propagation
kegg cell cycle
PMID:20126263, PMID:17568790

CDC25C|​S191_pho|​S198_pho|​S214_pho|​active@default

References
d_re313( DNA repair  map ):
Activation by PLK phosphorylation at S191, S198
Activation by CDC2 phosphorylation at S214
PMID:17596790

CDC25C|​S216_pho@default

References
d_re316( DNA repair  map ):
Phosphorylation of CDC25A, B or C by CHEK1 and CHEK2 inactivates CDC25, prevents activating de-phosphorylation of CDKs by CDC25 A, B, C
and stops cell cycle propagation
kegg cell cycle
PMID:20126263, PMID:17568790

CDC25C|​pho@Nucleus

References
c_re330( Cell cycle  map ):
Inactivated by phosphorylation by CHEK1 and CHEK2
PMID:12478465, PMID:12814430
Phosphorylation by CYCLINB-CDC2
PMID:11313986
c_re217( Cell cycle  map ):
dephosphorylation of CDC2 induce its activation
PMID:10373560, PMID:8348613, PMID:12814430
c_re233( Cell cycle  map ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430, PMID:1828290
c_re265( Cell cycle  map ):
PMID:12478465, PMID:12814430, PMID:9278512, PMID:9836640, PMID:9889122

CDC25C|​Ser216_pho|​pho@Nucleus

References
c_re265( Cell cycle  map ):
Inactivated by phosphorylation by CHEK1 and CHEK2
PMID:12478465, PMID:12814430, PMID:9278512, PMID:9836640, PMID:9889122
Phosphorylation by CYCLINB-CDC2
PMID:11313986
c_re264( Cell cycle  map ):
Phosphorylated CDC25 interacts with the 14-3-3 proteins which keep CDC25 outside of the nucleus.
PMID:12814430, PMID:11313932, PMID:11897663

CDC25C@Nucleus

References
c_re213( Cell cycle  map ):
Nuclear translocation during the G2 to M transition.
PMID:8348613
Translocation via the proteins of the 14-3-3 group.
PMID:12814430, PMID:9836640, PMID:9889122, PMID:11063929
c_re330( Cell cycle  map ):
Inactivated by phosphorylation by CHEK1 and CHEK2
PMID:12478465, PMID:12814430
Phosphorylation by CYCLINB-CDC2
PMID:11313986

CDC25C@Cytoplasm

References
c_re213( Cell cycle  map ):
Nuclear translocation during the G2 to M transition.
PMID:8348613
Translocation via the proteins of the 14-3-3 group.
PMID:12814430, PMID:9836640, PMID:9889122, PMID:11063929
c_re225( Cell cycle  map ):
Dephosphorylation of CDC2 induces its activation.
PMID:10373560, PMID:8348613, PMID:12814430
c_re237( Cell cycle  map ):
PMID:10373560, PMID:8348613, PMID:12814430, PMID:10827953, PMID:8440392, PMID:15456846, PMID:12524548, PMID:8119945, PMID:8428594, PMID:15107615, PMID:12411508

CDC25C|​Ser216_pho|​pho@Cytoplasm

References
c_re264( Cell cycle  map ):
Phosphorylated CDC25 interacts with the 14-3-3 proteins which keep CDC25 outside of the nucleus.
PMID:12814430, PMID:11313932, PMID:11897663


Modifications:
In compartment: Cytoplasm
  1. CDC25C@Cytoplasm map

  2. CDC25C|​Ser216_pho|​pho@Cytoplasm map

In compartment: Nucleus

  1. CDC25C@Nucleus map

  2. CDC25C|​pho@Nucleus map
  3. CDC25C|​Ser216_pho|​pho@Nucleus map

In compartment: default

  1. CDC25C@default map

  2. CDC25C|​S216_pho@default map
  3. CDC25C|​S191_pho|​S198_pho|​S214_pho|​active@default map

Participates in complexes:
In compartment: default

  1. 14-3-3*:​CDC25C|​S191_pho|​S198_pho|​S214_pho@default map

Participates in reactions:
As Reactant or Product:

  1. CDC25C@Cytoplasm map map CDC25C@Nucleus map

  2. CDC25C|​Ser216_pho|​pho@Nucleus map map CDC25C|​Ser216_pho|​pho@Cytoplasm map
  3. CDC25C|​pho@Nucleus map map CDC25C|​Ser216_pho|​pho@Nucleus map
  4. CDC25C@Nucleus map map CDC25C|​pho@Nucleus map
  5. CDC25C@default map map CDC25C|​S191_pho|​S198_pho|​S214_pho|​active@default map
  6. CDC25C@default map map CDC25C|​S216_pho@default map
  7. 14-3-3*@default map + CDC25C@default map map 14-3-3*:​CDC25C|​S191_pho|​S198_pho|​S214_pho@default map
  8. CDC25C|​S216_pho@default map map CDC25C@default map

As Catalyser:

  1. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map map CDK1|​Thr14_pho:​CyclinB*@Nucleus map

  2. CDK1|​Thr14_pho:​CyclinB*@Nucleus map map CDK1:​CyclinB*@Nucleus map
  3. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map map CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map
  4. CDK1|​Thr14_pho:​CyclinB*@Cytoplasm map map c_s767
  5. CDK1|​Tyr15_pho:​CyclinB*@Nucleus map map CDK1:​CyclinB*@Nucleus map
  6. CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map map c_s767
  7. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Cytoplasm map map CDK1|​Tyr15_pho:​CyclinB*@Cytoplasm map
  8. CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map map CDK1|​Tyr15_pho:​CyclinB*@Nucleus map
  9. CDK1|​Y14/15_pho|​T161_pho:​CyclinB1*@default map map CDK1|​T161_pho:​CyclinB1*@default map

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