Caveolin1*

Protein Caveolin1* map

Identifiers
caveolin 1, caveolae protein, 22kDa
HUGO:CAV1 HGNC:1527 ENTREZ:857 UNIPROT:Q03135 GENECARDS:CAV1 REACTOME:51448 KEGG:857 ATLASONC:CAV1ID932ch7q31 WIKI:CAV1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / TIGHT_JUNCTIONS  map

References
PMID:22671595
Caveolin-1 is an endocytic scaffolding protein
It binds independently to claudin-2 and occludin (co-immunoprecipitation assays).
The finding that caveolin-1 interacts with claudin-2 and occludin, but notwith claudin-4 or ZO-1, suggests a potential mechanism for selective retrieval of tight junction components.

Caveolin1*@Cytoplasm

References
e_re518( EMT  map ):
PMID:22671595
Caveolin-1 is an endocytic scaffolding protein
It binds independently to claudin-2 and occludin (co-immunoprecipitation assays).
The finding that caveolin-1 interacts with claudin-2 and occludin, but notwith claudin-4 or ZO-1, suggests a potential mechanism for selective retrieval of tight junction components.
e_re521( EMT  map ):
PMID:15471980
PMID:17498653
The phosphorylation of caveolin-1 served to recruit C-terminal Src-like kinase (Csk) to the integrin/caveolin-1 complex.
This recruitment results in additional regulation of SFK activity and induction of myosin light chain (MLC) phosphorylation.
Key components of this pathway were recruited to caveolar microdomains and dependent on the presence of the caveolin-1 protein.
PMID:21051664
p190RhoGAP links integrins and caveolin-1 (and thus caveolae) to RhoA in a mechanotransduction cascade


Modifications:
In compartment: Cytoplasm
  1. Caveolin1*@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. Caveolin1*:​ITGB1@Cytoplasm map

  2. Caveolin1*:​Claudin2*@Cytoplasm map
  3. Caveolin1*:​Occludin*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. Occludin*@Cytoplasm map + Caveolin1*@Cytoplasm map map Caveolin1*:​Occludin*@Cytoplasm map

  2. Caveolin1*@Cytoplasm map + Claudin2*@Cytoplasm map map Caveolin1*:​Claudin2*@Cytoplasm map
  3. Caveolin1*@Cytoplasm map + ITGB1@Cytoplasm map map Caveolin1*:​ITGB1@Cytoplasm map

As Catalyser:

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