c_re64

Reaction state_transition c_re64 map

DP1*:​E2F1@Nucleus map DP1*:​E2F1|​Lys_ace@Nucleus map

Reaction regulators:

Catalysis
  1. CBP*@Nucleus map
  2. p300*@Nucleus map
  3. PCAF*@Nucleus map



Maps_Modules
 Cell cycle  map  / E2F1  map

References
Acetylation of E2F1 (or activators E2Fs) on 3 lysine residues by PCAF increases its DNA-binding activity, stabilizes the protein and stimulates its transactivation potentiel.
PMID:15126619
Stabilisation of E2F1 by acetylation of Lys-117, Lys-120 and Lys-125 by PCAF and, to a lesser extent, p300 acetyltransferases.
PMID:15123636
Acetylated lysines on E2F1 are conserved and acetylated on E2F2 and E2F3. Acetylation by p300/CBP.
PMID:10753885

Confidence
REF=2 FUNC=4


Leave a Reply