c_re622

Reaction dissociation c_re622 map

DP1*:​E2F1|​Lys_ace:​PCAF*@Nucleus map DP1*:​E2F1|​Lys_ace|​Ser31_pho@Nucleus map + PCAF*@Nucleus map

Reaction regulators:

Catalysis
  1. ATR@Nucleus map
  2. ATM|​Ser 1981_pho@Nucleus map



Maps_Modules
 Cell cycle  map  / E2F1  map
 Cell cycle  map  / APOPTOSIS_ENTRY  map

References
Upon DNA damage, E2F is stabilized by ATM phosphorylation.
PMID:15838517, PMID:15140942
14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.
PMID:15494392

Confidence
REF=2 FUNC=4


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