c_re139

Reaction heterodimer_association c_re139 map

DP1*:​E2F1|​Lys_ace|​Ser31_pho@Nucleus map + TOPBP1@Nucleus map DP1*:​E2F1|​Lys_ace|​Ser31_pho:​TOPBP1@Nucleus map

No reaction regulators

Maps_Modules
 Cell cycle  map  / E2F1  map

References
Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair.
PMID:15838517, PMID:12697828

Confidence
REF=1 FUNC=5


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