c_re132

Reaction state_transition c_re132 map

p53*@Nucleus map p53*|​Ser15_pho@Nucleus map

Reaction regulators:

Catalysis
  1. ATM|​Ser 1981_pho:​NBS1*|​pho@Nucleus map
  2. CHEK2|​Thr68_pho@Nucleus map
  3. ATR@Nucleus map



Maps_Modules
 Cell cycle  map  / APOPTOSIS_ENTRY  map

References
PMID:15024084
ATM phosphorylates p53 in case of DNA double-strand breaks. ATR phosphorylates p53 in case of other types of DNA damages.
PMID:15140942
E2F1 stimulates ATM to phosphorylate p53 (and Chk2)
PMID:15140942, PMID:9843217, PMID:9733515, PMID:9733514

Confidence
REF=5 FUNC=5


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