BRIT1*

Protein BRIT1* map

Identifiers
BRCT-repeat inhibitor of TERT expression 1 (BRIT1), Microcephalin(MCPH1)
HUGO:MCPH1 HGNC:6954 ENTREZ:79648 UNIPROT:Q8NEM0 GENECARDS:MCPH1 KEGG:79648 ATLASONC:MCPH1ID44370ch8p23 WIKI:MCPH1

Maps_Modules
 DNA repair  map  / S_PHASE_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / HR  map

References
PMID:20376879, PMID:15220350, PMID:19525936, PMID:18660752

BRIT1*@default

References
d_re146( DNA repair  map ):
Link between Fanconi and HR:
PMID:15650050, PMID:19686080
d_re232( DNA repair  map ):
p53 inhibits BRCA1 expression, this is a negative loop as response to the up-regulation and stabilization of p53 by BRCA1:
PMID:10884389, PMID:12496474
BRIT1*/E2F1 complex activates BRCA1 and CHEK1 transcription during S-phase and G2/M checkpoints:
PMID:15220350, PMID:18660752
d_re485( DNA repair  map ):
PMID:15220350, PMID:18660752, PMID:20376879


Modifications:
In compartment: default
  1. BRIT1*@default map

Participates in complexes:
In compartment: default

  1. BRIT1*:​E2F1@default map

  2. BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@default map

Participates in reactions:
As Reactant or Product:

  1. RAD51:​XRCC2:​XRCC3@default map + BARD1:​BRCA1@default map + RAD52@default map + BRCA2:​DSS1*@default map + FANCN*@default map + FANCD2|​K561_ubi|​pho@default map + BRIT1*@default map + SFPQ@default map map BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@default map

  2. E2F1@default map + BRIT1*@default map map BRIT1*:​E2F1@default map

As Catalyser:

  1. gHR_DNA_st2*@Nucleus map map gHR_DNA_st3*@Nucleus map

  2. gBRCA1@default map map rBRCA1@default map
  3. gCHEK1@default map map rCHEK1@default map

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