BRCA2:FANCC:FANCG:XRCC3

Complex BRCA2:FANCC:FANCG:XRCC3 map


Complex composition:

  1. BRCA2 map
  2. FANCG map
  3. XRCC3 map
  4. FANCC map




BRCA2:​FANCC:​FANCG|​S7_pho:​XRCC3@default

Identifiers
NAME:BRCA2:FANCC:FANCG:XRCC3

Maps_Modules
 DNA repair  map  / HR  map

References
d_re203( DNA repair  map ):
The complex activates HR
PMID:18212739
d_re114( DNA repair  map ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833
d_re165( DNA repair  map ):
Link between Fanconi pathway and HR.
Fanconi pathway is a coordination of NER, TLS and HR
PMID:19686080:G
POLH activates D-loop extension. PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
PMID:16337602
For role of SMARCAL1/RPA in stalled replication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862

Confidence
REF=5 FUNC=4


Modifications:
Participates in complexes:
In compartment: default
  1. BRCA2:​FANCC:​FANCG|​S7_pho:​XRCC3@default map

Participates in reactions:
As Reactant or Product:

  1. FANCG|​S7_pho@default map + BRCA2@default map + XRCC3@default map + FANCC@default map map BRCA2:​FANCC:​FANCG|​S7_pho:​XRCC3@default map

As Catalyser:

  1. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map

  2. gFanconi_DNA_st4*@Nucleus map map gHR_DNA_st2*@Nucleus map

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