BRCA2

Protein BRCA2 map

Identifiers
breast cancer 2, early onset, FANCD1
HUGO:BRCA2 HGNC:1101 ENTREZ:675 UNIPROT:P51587 GENECARDS:BRCA2 REACTOME:50952 KEGG:675 ATLASONC:BRCA2ID164ch13q13 WIKI:BRCA2

Maps_Modules
 DNA repair  map  / HR  map
 DNA repair  map  / FANCONI  map

References
For HR pathway
PMID:19772495, PMID:16697054, PMID:19847258
For Fanconi anemia pathway
PMID:19686080, PMID:19622404, PMID:18931676

BRCA2@default

References
d_re120( DNA repair  map ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141
d_re166( DNA repair  map ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
d_re203( DNA repair  map ):
The complex activates HR
PMID:18212739


Modifications:
In compartment: default
  1. BRCA2@default map

Participates in complexes:
In compartment: default

  1. BRCA2:​DSS1*@default map

  2. BRCA2:​FANCC:​FANCG|​S7_pho:​XRCC3@default map
  3. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map
  4. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map
  5. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  6. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  7. BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@default map

Participates in reactions:
As Reactant or Product:

  1. BRCA2@default map + DSS1*@default map map BRCA2:​DSS1*@default map

  2. RAD51:​XRCC2:​XRCC3@default map + BARD1:​BRCA1@default map + RAD52@default map + BRCA2:​DSS1*@default map + FANCN*@default map + FANCD2|​K561_ubi|​pho@default map + BRIT1*@default map + SFPQ@default map map BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@default map
  3. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map + BRCA2@default map + NBS1*|​S343_pho@default map + RAD51@default map + PCNA@default map + H2AFX|​pho|​ubi@default map + TIP60*@default map map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  4. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map + BRCA2@default map + FANCJ*@default map + RPA1:​RPA2:​RPA3@default map + FANCN*@default map + FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map
  5. FANCG|​S7_pho@default map + BRCA2@default map + XRCC3@default map + FANCC@default map map BRCA2:​FANCC:​FANCG|​S7_pho:​XRCC3@default map
  6. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  7. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map

As Catalyser:

  1. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map

  2. G2 phase@default map map M phase@default map
  3. gHR_DNA_st2*@Nucleus map map gHR_DNA_st3*@Nucleus map
  4. gHR_DNA_st3*@Nucleus map map gHR_DNA_st4*@Nucleus map
  5. gFanconi_DNA_st4*@Nucleus map map gFanconi_DNA_st5*@Nucleus map
  6. gFanconi_DNA_st4*@Nucleus map map gHR_DNA_st2*@Nucleus map

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