Complex BRCA1:FANCJ* map

Complex composition:

  1. FANCJ* map
  2. BRCA1 map



 DNA repair  map  / FANCONI  map

Phosphorylated FANCJ bound to BRCA1 activates HR. Dephosphorylated FANCJ bound to MLH1 activates TLS via POLH. This is a switch mechanism:
d_re120( DNA repair  map ):
By CycB*/CDC2*:
G2/M transition
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
d_re136( DNA repair  map ):
Regulation of HR DNA repair foci formation regulation by UBc13:
For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862
MCM8*/MCM9* colocolize at RAD51 filament and reqired for interstrand crosslinks repair


Participates in complexes:
In compartment: default
  1. BRCA1:​FANCJ*|​S990_pho@default map

Participates in reactions:
As Reactant or Product:

  1. FANCJ*|​S990_pho@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map map BRCA1:​FANCJ*|​S990_pho@default map

As Catalyser:

  1. G2 phase@default map map M phase@default map

  2. gHR_DNA_st2*@Nucleus map map gHR_DNA_st3*@Nucleus map

33 thoughts on “BRCA1:FANCJ*

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