BRCA1:BRCA2:FANCD2:FANCI:H2AFX:NBS1*:PCNA:RAD51:TIP60*

Complex BRCA1:BRCA2:FANCD2:FANCI:H2AFX:NBS1*:PCNA:RAD51:TIP60* map


Complex composition:

  1. FANCI map
  2. FANCD2 map
  3. BRCA2 map
  4. BRCA1 map
  5. PCNA map
  6. H2AFX map
  7. RAD51 map
  8. NBS1* map
  9. TIP60* map




BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default

Identifiers
NAME:BRCA1:BRCA2:FANCD2:FANCI:H2AFX:NBS1*:PCNA:RAD51:TIP60*

Maps_Modules
 DNA repair  map  / HR  map
 DNA repair  map  / FANCONI  map

References
The complex participates in the HR and S-checkpoint
PMID:12239151, PMID:19686080
For Fanconi
PMID:19622404
The complex is considered to be the actual repair structure of the pathway.
MODULE:G1_CC_PHASE map
MODULE:S_CC_PHASE map
Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. Followed by FANCD2 and FANCI DE-uiquitination by USP1/UAF1 to allow the repair process
PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559
d_re248( DNA repair  map ):
d_re136( DNA repair  map ):
Regulation of HR DNA repair foci formation regulation by UBc13:
PMID:17349954
For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862
MCM8*/MCM9* colocolize at RAD51 filament and reqired for interstrand crosslinks repair
PMID:22771115
d_re165( DNA repair  map ):
Link between Fanconi pathway and HR.
Fanconi pathway is a coordination of NER, TLS and HR
PMID:19686080:G
POLH activates D-loop extension. PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
PMID:16337602
For role of SMARCAL1/RPA in stalled replication fork repair and in the homologous recombination:

Confidence
REF=5 FUNC=4

BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default

Identifiers
NAME:BRCA1:BRCA2:FANCD2:FANCI:H2AFX:NBS1*:PCNA:RAD51:TIP60*

Maps_Modules
 DNA repair  map  / HR  map
 DNA repair  map  / FANCONI  map

References
The complex participates in the HR and S-checkpoint
PMID:12239151, PMID:19686080
For Fanconi
PMID:19622404
The complex is considered to be the actual repair structure of the pathway.
MODULE:G1_CC_PHASE map
MODULE:S_CC_PHASE map
Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. Followed by FANCD2 and FANCI DE-uiquitination by USP1/UAF1 to allow the repair process
PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559
d_re166( DNA repair  map ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
d_re248( DNA repair  map ):

Confidence
REF=5 FUNC=4


Modifications:
Participates in complexes:
In compartment: default
  1. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map

  2. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map

Participates in reactions:
As Reactant or Product:

  1. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map + BRCA2@default map + NBS1*|​S343_pho@default map + RAD51@default map + PCNA@default map + H2AFX|​pho|​ubi@default map + TIP60*@default map map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map

  2. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map

As Catalyser:

  1. gHR_DNA_st2*@Nucleus map map gHR_DNA_st3*@Nucleus map

  2. gFanconi_DNA_st4*@Nucleus map map gHR_DNA_st2*@Nucleus map

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