BRCA1:BRCA2:FANCD2:FANCI:FANCJ*:FANCN*:RPA1:RPA2:RPA3

Complex BRCA1:BRCA2:FANCD2:FANCI:FANCJ*:FANCN*:RPA1:RPA2:RPA3 map


Complex composition:

  1. FANCI map
  2. FANCD2 map
  3. BRCA2 map
  4. BRCA1 map
  5. FANCJ* map
  6. FANCN* map
  7. RPA1 map
  8. RPA2 map
  9. RPA3 map




BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default

Identifiers
NAME:BRCA1:BRCA2:FANCD2:FANCI:FANCJ*:FANCN*:RPA1:RPA2:RPA3

Maps_Modules
 DNA repair  map  / HR  map
 DNA repair  map  / FANCONI  map

References
PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559
d_re249( DNA repair  map ):
Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. Followed by FANCD2 and FANCI DE-uiquitination by USP1/UAF1 to allow the repair process:

Confidence
REF=4 FUNC=4

BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default

Identifiers
NAME:BRCA1:BRCA2:FANCD2:FANCI:FANCJ*:FANCN*:RPA1:RPA2:RPA3

Maps_Modules
 DNA repair  map  / HR  map
 DNA repair  map  / FANCONI  map

References
PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559
d_re249( DNA repair  map ):
Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. Followed by FANCD2 and FANCI DE-uiquitination by USP1/UAF1 to allow the repair process:
d_re139( DNA repair  map ):
PMID:19686080
POLH participates in the D-loop formation in HR:
PMID:16337602, PMID:16337601
Complex PolN:HEL308 participates in HR and in Fanconi PMID:19995904
d_re163( DNA repair  map ):
POLH activates D-loop extention
PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
PMID:16337602
Presence of FA core complex is essential for thePolZ/Rev1 activity:
PMID:18448394
PoLQ/HEL308 in Fancon:
PMID:18472307
d_re165( DNA repair  map ):
Link between Fanconi pathway and HR.
Fanconi pathway is a coordination of NER, TLS and HR
PMID:19686080:G
POLH activates D-loop extension. PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
For role of SMARCAL1/RPA in stalled replication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862

Confidence
REF=5 FUNC=4


Modifications:
Participates in complexes:
In compartment: default
  1. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map

  2. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map

Participates in reactions:
As Reactant or Product:

  1. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map + BRCA2@default map + FANCJ*@default map + RPA1:​RPA2:​RPA3@default map + FANCN*@default map + FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map

  2. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map

As Catalyser:

  1. gHR_DNA_st3*@Nucleus map map gHR_DNA_st4*@Nucleus map

  2. gFanconi_DNA_st4*@Nucleus map map gFanconi_DNA_st5*@Nucleus map
  3. gFanconi_DNA_st4*@Nucleus map map gHR_DNA_st2*@Nucleus map

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