BRCA1

Protein BRCA1 map

Identifiers
breast cancer 1, early onset
HUGO:BRCA1 HGNC:1100 ENTREZ:672 UNIPROT:P38398 GENECARDS:BRCA1 REACTOME:50950 KEGG:672 ATLASONC:BRCA1ID163ch17q21 WIKI:BRCA1

Maps_Modules
 Apoptosis  map  / MITOCH_METABOLISM  map
 DNA repair  map  / G1_S_CHECKPOINT  map
 DNA repair  map  / S_PHASE_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / HR  map
 DNA repair  map  / FANCONI  map

References
For S-phase checkpoint
PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331

BRCA1@Cytoplasm

References
a_re1070:( Apoptosis  map ) PMID:16326698

BRCA1@Site of DNA damage

References
a_re1502( Apoptosis  map ):
influenceDelete: re to products
PMID:18087291
review
a_re1508( Apoptosis  map ):
influenceDelete: re to reactants
PMID:19342239
genetic arguments for the components of this complex being recruited all together

BRCA1|​ubi@default

References
d_re523( DNA repair  map ):
HSP90 redirects BRCA1 to degradation, inhibits HR and G2/M chechpoint, increases sensitivity to cross-linking agents
PMID:22869732

BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default

References
d_re33:( DNA repair  map ) PMID:15485915
d_re34:( DNA repair  map ) PMID:19788416
d_re48( DNA repair  map ):
BRCA1 stabilises p53 and causes activation of p53-dependent DNA-repair genes and activation of checkpoint, but no apoptoss:
PMID:12024039 , PMID:12496474
d_re118( DNA repair  map ):
BRCA1 ubiquitinates CtIP that allows propagation through G2 to M checkpoint
PMID:16818604
PMID:19357644
d_re121( DNA repair  map ):
The shift from C_NHEJ to HR is regulated by the CtIP and BRCA1. CDK1-dependent phosphorylation of CtIP regulates the shift: PMID:19357644
PMID:15485915
d_re166( DNA repair  map ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
d_re204:( DNA repair  map ) PMID:15242590
d_re226( DNA repair  map ):
BRCA1 up-regulates transcription of GADD45 in p53 independed manner:
PMID:10367887, PMID:10962562
PMID:19004803, PMID:12496474
p53 enhances transcription of GADD45:
PMID:9892649, PMID:10779360
p53 regulated global genomic NER at the level of DNA damage recognition involving GADD45, XPC, DDB2:
PMID:12771027, PMID:9346961
d_re228( DNA repair  map ):
BRCA1 enhances transcription of DDB2 in p53 independent manner
PMID:19004803, PMID:12496474, PMID:12170778
p53 enhances transcription of DDB2:
d_re231( DNA repair  map ):
BRCA1 upregulates transcription of XPC in p53 independed manner:
p53 enhances transcription of XPC:
d_re344:( DNA repair  map ) CHECKPOINT is p53_dependent_G1S_checkpoint

BRCA1@default

References
d_re523( DNA repair  map ):
HSP90 redirects BRCA1 to degradation, inhibits HR and G2/M chechpoint, increases sensitivity to cross-linking agents
PMID:22869732


Modifications:
In compartment: Cytoplasm
  1. BRCA1@Cytoplasm map

In compartment: Mitochondrial Matrix

  1. BRCA1@Mitochondrial Matrix map

In compartment: Site of DNA damage

  1. BRCA1@Site of DNA damage map

  2. BRCA1@Site of DNA damage map

In compartment: default

  1. BRCA1@default map

  2. BRCA1|​ubi@default map
  3. BRCA1|​S308_pho@default map
  4. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map

Participates in complexes:
In compartment: Cytoplasm

  1. ACACA|​S79_pho:​BRCA1@Cytoplasm map

In compartment: Site of DNA damage

  1. BARD1:​BRCA1:​BRCC3:​FAM175A:​UIMC1@Site of DNA damage map

In compartment: default

  1. BARD1:​BRCA1@default map

  2. AURKA:​BRCA1|​S308_pho@default map
  3. BRCA1:​SMC1*|​S957_pho@default map
  4. BRCA1:​SMC3|​S1083_pho@default map
  5. BRCA1:​FANCJ*|​S990_pho@default map
  6. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map
  7. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​E2F1:​RB1@default map
  8. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map
  9. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map
  10. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map
  11. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  12. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  13. BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@default map

Participates in reactions:
As Reactant or Product:

  1. rheavy strand transcript*@Mitochondrial Matrix map map rMT-TT@Mitochondrial Matrix map + rMT-ND5@Mitochondrial Matrix map + BARD1@Mitochondrial Matrix map + PYCARD@Mitochondrial Matrix map + BAX@Mitochondrial Matrix map + rMT-ND4@Mitochondrial Matrix map + rMT-ND4L@Mitochondrial Matrix map + BRCA1@Mitochondrial Matrix map + rMT-ND3@Mitochondrial Matrix map + BIRC5@Mitochondrial Matrix map + rMT-CO3@Mitochondrial Matrix map + rMT-ATP6@Mitochondrial Matrix map + rMT-ATP8@Mitochondrial Matrix map + rMT-TK@Mitochondrial Matrix map + rMT-CO2@Mitochondrial Matrix map + rMT-TD@Mitochondrial Matrix map + rMT-CO1@Mitochondrial Matrix map + rMT-TW@Mitochondrial Matrix map + rMT-ND2@Mitochondrial Matrix map + rMT-TM@Mitochondrial Matrix map + rMT-TI@Mitochondrial Matrix map + rMT-ND1@Mitochondrial Matrix map + rMT-TL1@Mitochondrial Matrix map + rMT-RNR2@Mitochondrial Matrix map + rMT-TV@Mitochondrial Matrix map + rMT-RNR1@Mitochondrial Matrix map + rMT-TF@Mitochondrial Matrix map + rMT-CYB@Mitochondrial Matrix map

  2. BRCA1@Cytoplasm map + ACACA|​S1263_pho@Cytoplasm map map ACACA|​S79_pho:​BRCA1@Cytoplasm map
  3. BRCA1@Site of DNA damage map map BRCA1@Site of DNA damage map
  4. BRCA1@Site of DNA damage map + FAM175A@Site of DNA damage map + UIMC1@Site of DNA damage map + BRCC3@Site of DNA damage map + BARD1@Site of DNA damage map map BARD1:​BRCA1:​BRCC3:​FAM175A:​UIMC1@Site of DNA damage map
  5. BARD1:​BRCA1:​BRCC3:​FAM175A:​UIMC1@Site of DNA damage map map BRCA1@Site of DNA damage map + UIMC1@Site of DNA damage map + FAM175A@Site of DNA damage map + BRCC3@Site of DNA damage map + BARD1@Site of DNA damage map
  6. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map map BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map
  7. CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map map BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map
  8. BARD1@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map map BARD1:​BRCA1@default map
  9. RAD51:​XRCC2:​XRCC3@default map + BARD1:​BRCA1@default map + RAD52@default map + BRCA2:​DSS1*@default map + FANCN*@default map + FANCD2|​K561_ubi|​pho@default map + BRIT1*@default map + SFPQ@default map map BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@default map
  10. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map + BRCA2@default map + NBS1*|​S343_pho@default map + RAD51@default map + PCNA@default map + H2AFX|​pho|​ubi@default map + TIP60*@default map map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  11. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map + BRCA2@default map + FANCJ*@default map + RPA1:​RPA2:​RPA3@default map + FANCN*@default map + FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map map BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map
  12. FANCJ*|​S990_pho@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map map BRCA1:​FANCJ*|​S990_pho@default map
  13. rBRCA1@default map map BRCA1@default map
  14. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  15. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map
  16. BRCA1@default map map BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map
  17. E2F1:​RB1@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map map BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​E2F1:​RB1@default map
  18. BRCA1@default map map BRCA1|​S308_pho@default map
  19. BRCA1|​S308_pho@default map + AURKA@default map map AURKA:​BRCA1|​S308_pho@default map
  20. BRCA1@default map + SMC1*|​S957_pho|​S966_pho@default map map BRCA1:​SMC1*|​S957_pho@default map
  21. SMC3|​S1083_pho@default map + BRCA1@default map map BRCA1:​SMC3|​S1083_pho@default map
  22. BRCA1@default map map BRCA1|​ubi@default map
  23. BRCA1|​ubi@default map map degraded

As Catalyser:

  1. DNA~damage@Nucleus map + gDNA2@Nucleus map map DNA~integrity@Nucleus map

  2. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map
  3. G1 phase@default map map S phase@default map
  4. CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map map CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map
  5. G2 phase@default map map M phase@default map
  6. gHR_DNA_st2*@Nucleus map map gHR_DNA_st3*@Nucleus map
  7. gHR_DNA_st3*@Nucleus map map gHR_DNA_st4*@Nucleus map
  8. gFanconi_DNA_st4*@Nucleus map map gFanconi_DNA_st5*@Nucleus map
  9. gFanconi_DNA_st4*@Nucleus map map gHR_DNA_st2*@Nucleus map
  10. gGADD45*@default map map rGADD45*@default map
  11. gDDB2@default map map rDDB2@default map
  12. gXPC@default map map rXPC@default map
  13. CHEK1@default map map CHEK1|​pho|​active@default map
  14. p53*@default map map p53*|​pho|​ace|​active@default map
  15. gCIP/KIP*@default map map rCIP/KIP*@default map
  16. gMAD2*@default map map rMAD2*@default map
  17. gBUB1@default map map rBUB1@default map
  18. No DNA replicarion@default map map DNA replicarion@default map
  19. p53*@default map map degraded
  20. gC_NHEJ_DNA_st1*@Nucleus map map gC_NHEJ_DNA_st2*@Nucleus map

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