BRAF:GRB2:KSR1:MEK*:RAS*:RTK*:SOS*

Complex BRAF:GRB2:KSR1:MEK*:RAS*:RTK*:SOS* map


Complex composition:

  1. KSR1 map
  2. GRB2 map
  3. SOS* map
  4. BRAF map
  5. MEK* map
  6. RAS* map
  7. RTK* map




BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane

Identifiers
NAME:BRAF:GRB2:KSR1:MEK*:RAS*:RTK*:SOS*

References
s_mpk1_re15( Survival  map ):
After having translocated to the plasma membrane KSR1 is able to interact with activated B-Raf and ERK.
PMID:17496910
s_mpk1_re16( Survival  map ):
ERK recruitment is enhanced by KSR1. ERK is then phosphorylated by MEK.
PMID:19541618
s_mpk1_re30( Survival  map ):
KSR1 is cleaved by CASPASE3 in two regions: the C-ter region which mediates MEK binding and the N-ter region which contains the ERK binding site and the C1 domain required for plasma membrane localisation
PMID:17613518

Confidence
REF=2 FUNC=4


Modifications:
Participates in complexes:
In compartment: Plasma Membrane
  1. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map

Participates in reactions:
As Reactant or Product:

  1. BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + KSR1:​MEK*@Cytoplasm map map BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map

  2. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + ERK*@Cytoplasm map map BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  3. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map BRAF|​pho:​GRB2:​KSR1-NTER*:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + KSR1-CTER*:​MEK*@Cytoplasm map

As Catalyser:

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