BRAF:ERK*:GRB2:KSR1:MEK*:RAS*:RTK*:SOS*

Complex BRAF:ERK*:GRB2:KSR1:MEK*:RAS*:RTK*:SOS* map


Complex composition:

  1. GRB2 map
  2. SOS* map
  3. KSR1 map
  4. RTK* map
  5. ERK* map
  6. MEK* map
  7. BRAF map
  8. RAS* map




BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane

Identifiers
NAME:BRAF:ERK*:GRB2:KSR1:MEK*:RAS*:RTK*:SOS*

References
s_mpk1_re16( Survival  map ):
ERK recruitment is enhanced by KSR1. ERK is then phosphorylated by MEK.
PMID:19541618
s_mpk1_re29( Survival  map ):
Docking of activated ERK to the KSR1 scaffold negatively regulates the interaction between KSR1 and B-Raf.
s_s_mpk1_re29( Survival  map ):

Confidence
REF=1 FUNC=4


Modifications:
Participates in complexes:
In compartment: Plasma Membrane
  1. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map

Participates in reactions:
As Reactant or Product:

  1. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + ERK*@Cytoplasm map map BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map

  2. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map KSR1:​MEK*@Cytoplasm map + BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + ERK*|​pho|​pho@Cytoplasm map
  3. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map + BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map

As Catalyser:

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