BNIP2

Protein BNIP2 map

Identifiers
BCL2/adenovirus E1B 19kDa interacting protein 2
“BCL2/adenovirus E1B 19kD-interacting protein 2″
HUGO:BNIP2 HGNC:1083 ENTREZ:663 UNIPROT:Q12982 GENECARDS:BNIP2 REACTOME:200758 KEGG:663 ATLASONC:GC_BNIP2 WIKI:BNIP2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:10551883
FGFR1 regulates activity of CDC42 by binding and phosphorylating thus inactivating BCL2.
Phosphorylated BCL2 binds to another CDC42_GAP, ARHGAP1 and neutralize the GAP activity of ARHGAP1 as well.

BNIP2@Cytoplasm

References
e_re883( EMT  map ):
PMID:10551883
FGFR1 regulates activity of CDC42 by binding and phosphorylating thus inactivating BCL2.
Phosphorylated BCL2 binds to another CDC42_GAP, ARHGAP1 and neutralize the GAP activity of ARHGAP1 as well.
e_re802( EMT  map ):
Rac1 stimulates actin polymerization by activation of WAS protein family (WASF1 and WASF2)
PMID:16212495
PMID:9843499
PMID:16702231
PMID:12181570
Rac1 binds to NCKAP1 and CYFIP2 and also promotes NCK1 binding to NCKAP1.
This binding inhibits NCKAP1 and CYFIP2 binding to WASF1 and promotes release of the complex of WASF1 and BRK1, thus activating WASF1.
Activated WASF1 then stimulates ARP2/3 that mediates actin cytoskeletal polymerizatioin

BNIP2|​pho@Cytoplasm

References
e_re894( EMT  map ):
PMID:10551883
FGFR1 regulates activity of CDC42 by binding and phosphorylating thus inactivating BCL2.
Phosphorylated BCL2 binds to another CDC42_GAP, ARHGAP1 and neutralize the GAP activity of ARHGAP1 as well.


Modifications:
In compartment: Cytoplasm
  1. BNIP2@Cytoplasm map

  2. BNIP2|​pho@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. ARHGAP1:​BNIP2|​pho@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. CYFIP2@Cytoplasm map map BNIP2@Cytoplasm map

  2. NCKAP1@Cytoplasm map map BNIP2@Cytoplasm map
  3. CDC42_GAPs*@Cytoplasm map map BNIP2@Cytoplasm map
  4. BNIP2@Cytoplasm map map BNIP2|​pho@Cytoplasm map
  5. ARHGAP1@Cytoplasm map + BNIP2|​pho@Cytoplasm map map ARHGAP1:​BNIP2|​pho@Cytoplasm map

As Catalyser:

  1. WASF1@Cytoplasm map map WASF1@Cytoplasm map

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