e_re1197( EMT ):
Direct activation of Bmi1 expression by Twist1 using transient transfection.
Twist1 directly activates BMI1 transcription by binding to the E-box in intron 1 of the BMI1 gene.
SNAI2 induces BMI1 expression
e_re1198( EMT ):
Protein expression of Bmi1, Sox2, p63 was reduced after ZEB1 knockdown.
ZEB1 knockdown not only resulted in reduced invasion and metastasis, but also in reduced tumorigenicity.
ZEB1 is also necessary for the self-renewing capacity.
ZEB1 is crucial for drug resistance in pancreatic cancer cells. This supports data showing that EMT activators (Twist and Snail) confer anti-apoptotic properties
In compartment: Nucleus
Participates in complexes:
In compartment: Cytoplasm
Participates in reactions:
As Reactant or Product:
- rBMI1_BIRC5_KLF4_SOX2_SNAI1_ZEB2*@Nucleus → rBMI1@Nucleus
- rBIM1_KLF4_SOX2*@Nucleus → rBMI1@Nucleus
- gBMI1@Nucleus → rBMI1@Nucleus
- rBMI1@Nucleus → BMI1@Cytoplasm