BMI1

RNA BMI1 map

Identifiers
BMI1 polycomb ring finger oncogene
HUGO:BMI1 HGNC:1066 ENTREZ:648 UNIPROT:P35226 GENECARDS:BMI1 KEGG:648 ATLASONC:BMI1ID807ch10p12 WIKI:BMI1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:21224848

rBMI1@Nucleus

References
e_re1197( EMT  map ):
PMID:21919891
PMID:21733352
Direct activation of Bmi1 expression by Twist1 using transient transfection.
PMID:20818389
Twist1 directly activates BMI1 transcription by binding to the E-box in intron 1 of the BMI1 gene.
PMID:17550342
SNAI2 induces BMI1 expression
e_re1198( EMT  map ):
PMID:19935649
Protein expression of Bmi1, Sox2, p63 was reduced after ZEB1 knockdown.
ZEB1 knockdown not only resulted in reduced invasion and metastasis, but also in reduced tumorigenicity.
ZEB1 is also necessary for the self-renewing capacity.
ZEB1 is crucial for drug resistance in pancreatic cancer cells. This supports data showing that EMT activators (Twist and Snail) confer anti-apoptotic properties


Modifications:
In compartment: Nucleus
  1. rBMI1@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. BMI1:​Cyclin D1*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. rBMI1_BIRC5_KLF4_SOX2_SNAI1_ZEB2*@Nucleus map map rBMI1@Nucleus map

  2. rBIM1_KLF4_SOX2*@Nucleus map map rBMI1@Nucleus map
  3. gBMI1@Nucleus map map rBMI1@Nucleus map
  4. rBMI1@Nucleus map map BMI1@Cytoplasm map

As Catalyser:

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