BLM:FAAP100*:FAAP20*:FAAP24*:FANCA:FANCB:FANCC:FANCE:FANCF:FANCG:FANCL:FANCM:HES1

Complex BLM:FAAP100*:FAAP20*:FAAP24*:FANCA:FANCB:FANCC:FANCE:FANCF:FANCG:FANCL:FANCM:HES1 map


Complex composition:

  1. BLM map
  2. HES1 map
  3. FANCL map
  4. FAAP100* map
  5. FANCB map
  6. FANCE map
  7. FANCF map
  8. FANCC map
  9. FANCA map
  10. FANCM map
  11. FAAP24* map
  12. FAAP20* map
  13. FANCG map




BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default

Identifiers
NAME:BLM:FAAP100*:FAAP20*:FAAP24*:FANCA:FANCB:FANCC:FANCE:FANCF:FANCG:FANCL:FANCM:HES1

Maps_Modules
 DNA repair  map  / FANCONI  map
 DNA repair  map  / TLS  map

References
The complex has two functions, FANCM and BLM create reverse-fork structure creating four way junction and allowing initiation of repair for FA core complex and the following steps evolving NER and HR proteins.
FANCL ubiquitinates FANCD2 that together with FANCI initiates the repair
PMID:19622404
FA core complex regulates REV1 and activated TLS
PMID:22266823
d_re156( DNA repair  map ):
MRN complex co-locolises at the FA foci and modulates propagation of ICL repair by Fanconi PMID:15136767, PMID:19622404
RPA is required for the replication fork block and remodeling toward DNA repair:
For role of SNM1B in Fanconi and S-phase checkpoint
PMID:18469862
d_re158( DNA repair  map ):
S phase checkpoint controls and induces FANCD2 monoubiquitusation to start Fanconi and HR
PMID:12239151
d_re163( DNA repair  map ):
PMID:19686080
POLH activates D-loop extention
PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
PMID:16337602
Presence of FA core complex is essential for thePolZ/Rev1 activity:
PMID:18448394
PoLQ/HEL308 in Fancon:
PMID:18472307
d_re187( DNA repair  map ):
PMID:18931676, PMID:19686080
Link between cell cycle and activation of Fanconi pathway
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723
d_re206( DNA repair  map ):
Phosphorylation of NBS1 bt ATR in responce to crosslink-activation of S phase checkpoint
PMID:15136767
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop cell cycle propagation:
d_re489( DNA repair  map ):
Reaction (id=re180, name=; CellCycle_DNArepair_18_12_2010_Version3.xml)
Phosphorilated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
PMID:17035102
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
PMID:19225445
REV1 interacts with many TLS polymerases:
PMID:14657033
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158
For TLS
PMID:19258535

Confidence
REF=5 FUNC=4


Modifications:
Participates in complexes:
In compartment: default
  1. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map

Participates in reactions:
As Reactant or Product:

  1. FANCA|​pho:​FANCG|​S7_pho@default map + FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF@default map + FAAP24*:​FANCM@default map + FAAP100*:​FANCB:​FANCL@default map + BLM@Nucleus map + HES1@default map + FAAP20*@default map map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map

  2. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map + TOP3A@default map + RPA1:​RPA2:​RPA3@default map map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​RPA1:​RPA2:​RPA3:​TOP3A@default map

As Catalyser:

  1. gFanconi_DNA_st2*@Nucleus map map gFanconi_DNA_st3*@Nucleus map

  2. FANCD2|​pho@default map map FANCD2|​K561_ubi|​pho@default map
  3. FANCI|​pho@default map map FANCI|​K523_ubi|​pho@default map
  4. gFanconi_DNA_st4*@Nucleus map map gFanconi_DNA_st5*@Nucleus map
  5. FANCD2@default map map FANCD2|​pho@default map
  6. FANCD2|​K561_ubi|​pho@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + ATR|​pho|​active@Nucleus map map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  7. gTLS_DNA_st1*@Nucleus map map gTLS_DNA_st2*@Nucleus map

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