BLM:EXO1

Complex BLM:EXO1 map


Complex composition:

  1. BLM map
  2. EXO1 map




BLM:​EXO1@Nucleus

Identifiers
NAME:BLM:EXO1

Maps_Modules
 DNA repair  map  / HR  map

References
d_re114( DNA repair  map ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833

Confidence
REF=5 FUNC=4


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. BLM:​EXO1@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. EXO1@default map + BLM@Nucleus map map BLM:​EXO1@Nucleus map

As Catalyser:

  1. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map

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