BLM

Protein BLM map

Identifiers
Bloom syndrome, RecQ helicase-like
HUGO:BLM HGNC:1058 ENTREZ:641 UNIPROT:P54132 GENECARDS:BLM REACTOME:50864 KEGG:641 ATLASONC:BLM109 WIKI:BLM

Maps_Modules
 DNA repair  map  / HR  map
 DNA repair  map  / FANCONI  map
 DNA repair  map  / TLS  map

References
For HR pathway, PMID:22657828
PMID:19772495, PMID:16697054, PMID:19847258
For Fanconi anemia pathway
PMID:19686080, PMID:19622404, PMID:18931676
FA core complex regulates REV1 and activated TLS
PMID:22266823
BLM in telomere maintenance
PMID:23253856
Resolving stalled replication fork
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737

BLM@Nucleus

References
d_re24:( DNA repair  map ) PMID:22973052
d_re105( DNA repair  map ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737
d_re142:( DNA repair  map ) PMID:19490890


Modifications:
In compartment: Nucleus
  1. BLM@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. BLM:​EXO1@Nucleus map

In compartment: default

  1. BLM:​RMI1:​TOP3A@default map

  2. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
  3. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​RPA1:​RPA2:​RPA3:​TOP3A@default map

Participates in reactions:
As Reactant or Product:

  1. EXO1@default map + BLM@Nucleus map map BLM:​EXO1@Nucleus map

  2. TOP3A@default map + BLM@Nucleus map + RMI1@default map map BLM:​RMI1:​TOP3A@default map
  3. FANCA|​pho:​FANCG|​S7_pho@default map + FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF@default map + FAAP24*:​FANCM@default map + FAAP100*:​FANCB:​FANCL@default map + BLM@Nucleus map + HES1@default map + FAAP20*@default map map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
  4. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map + TOP3A@default map + RPA1:​RPA2:​RPA3@default map map BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​RPA1:​RPA2:​RPA3:​TOP3A@default map
  5. BLM@Nucleus map map Telomere maintenance@Nucleus map

As Catalyser:

  1. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map

  2. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map
  3. gHR_DNA_st5*@Nucleus map map gHR_DNA_st6*@Nucleus map
  4. gFanconi_DNA_st2*@Nucleus map map gFanconi_DNA_st3*@Nucleus map
  5. FANCD2|​pho@default map map FANCD2|​K561_ubi|​pho@default map
  6. FANCI|​pho@default map map FANCI|​K523_ubi|​pho@default map
  7. gFanconi_DNA_st4*@Nucleus map map gFanconi_DNA_st5*@Nucleus map
  8. FANCD2@default map map FANCD2|​pho@default map
  9. FANCD2|​K561_ubi|​pho@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + ATR|​pho|​active@Nucleus map map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  10. PCNA@default map + FEN1@default map + WRN@Nucleus map map FEN1:​PCNA:​WRN@default map
  11. gTLS_DNA_st1*@Nucleus map map gTLS_DNA_st2*@Nucleus map

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