BIRC5

Protein BIRC5 map

Identifiers
baculoviral IAP repeat containing 5
HUGO:BIRC5 HGNC:593 ENTREZ:332 UNIPROT:O15392 GENECARDS:BIRC5 REACTOME:50852 KEGG:332 ATLASONC:GC_BIRC5 WIKI:BIRC5
baculoviral IAP repeat-containing 5, Surverin

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / CASPASES  map

References
synonym:survivin
Component of the chromosomal passenger complex (CPC)
PMID:15249581, PMID:15249581, PMID:17956729, PMID:12925766, PMID:16571674

BIRC5@Cytoplasm

References
a_re669:( Apoptosis  map ) PMID:11069302
a_re718:( Apoptosis  map ) PMID:14614132

BIRC5|​T34_pho@Cytoplasm

References
a_re669:( Apoptosis  map ) PMID:11069302
a_re668( Apoptosis  map ):
PMID:12773388
in vitro survivin_BIRC5 alone does not suppress CASP3/7/9 activities
in HepG2, interaction by coIP of endogenous proteins
in HEK293 or in vitro, preferential binding to T34 phosphorylated BIRC5, as determined through the use of unphosphorylatable or phosphomimetic mutants
in Hela expression of a dominant negative CDC2 decreases interaction
a_re737( Apoptosis  map ):
PMID:12660240
in Hela, upon taxol treatment, interaction detected by GST pull-down, BIRC5 antagonizes DIABLO pro-apoptotic effect


Modifications:
In compartment: Cytoplasm
  1. BIRC5@Cytoplasm map

  2. BIRC5|​T34_pho@Cytoplasm map

In compartment: Mitochondrial Matrix

  1. BIRC5@Mitochondrial Matrix map

In compartment: default

  1. BIRC5@default map

Participates in complexes:
In compartment: Cytoplasm

  1. BIRC5|​T34_pho:​HBXIP@Cytoplasm map

  2. BIRC5|​T34_pho:​DIABLO@Cytoplasm map

In compartment: default

  1. AURKB|​T232_pho:​BIRC5:​Borealin*|​pho:​INCENP|​pho@default map

Participates in reactions:
As Reactant or Product:

  1. rheavy strand transcript*@Mitochondrial Matrix map map rMT-TT@Mitochondrial Matrix map + rMT-ND5@Mitochondrial Matrix map + BARD1@Mitochondrial Matrix map + PYCARD@Mitochondrial Matrix map + BAX@Mitochondrial Matrix map + rMT-ND4@Mitochondrial Matrix map + rMT-ND4L@Mitochondrial Matrix map + BRCA1@Mitochondrial Matrix map + rMT-ND3@Mitochondrial Matrix map + BIRC5@Mitochondrial Matrix map + rMT-CO3@Mitochondrial Matrix map + rMT-ATP6@Mitochondrial Matrix map + rMT-ATP8@Mitochondrial Matrix map + rMT-TK@Mitochondrial Matrix map + rMT-CO2@Mitochondrial Matrix map + rMT-TD@Mitochondrial Matrix map + rMT-CO1@Mitochondrial Matrix map + rMT-TW@Mitochondrial Matrix map + rMT-ND2@Mitochondrial Matrix map + rMT-TM@Mitochondrial Matrix map + rMT-TI@Mitochondrial Matrix map + rMT-ND1@Mitochondrial Matrix map + rMT-TL1@Mitochondrial Matrix map + rMT-RNR2@Mitochondrial Matrix map + rMT-TV@Mitochondrial Matrix map + rMT-RNR1@Mitochondrial Matrix map + rMT-TF@Mitochondrial Matrix map + rMT-CYB@Mitochondrial Matrix map

  2. rBIRC5@Nucleus map map BIRC5@Cytoplasm map
  3. HBXIP@Cytoplasm map + BIRC5|​T34_pho@Cytoplasm map map BIRC5|​T34_pho:​HBXIP@Cytoplasm map
  4. BIRC5@Cytoplasm map map BIRC5|​T34_pho@Cytoplasm map
  5. BIRC5@Cytoplasm map map degraded
  6. BIRC5|​T34_pho@Cytoplasm map + DIABLO@Cytoplasm map map BIRC5|​T34_pho:​DIABLO@Cytoplasm map
  7. Borealin*|​pho@default map + AURKB|​T232_pho@default map + INCENP|​pho@default map + BIRC5@default map map AURKB|​T232_pho:​BIRC5:​Borealin*|​pho:​INCENP|​pho@default map

As Catalyser:

  1. Caspase9*@Cytoplasm map map cleaved~Caspase9*@Cytoplasm map

  2. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@default map + MAD2*@default map + BUBR1*@default map + BUB3@default map + MAD1*|​pho@default map + BUB1|​pho@default map map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​BUB1|​pho:​BUB3:​BUBR1*:​CDC20:​MAD1*|​pho:​MAD2*@default map

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