BIRC2

Protein BIRC2 map

Identifiers
baculoviral IAP repeat containing 2
HUGO:BIRC2 HGNC:590 ENTREZ:329 UNIPROT:Q13490 GENECARDS:BIRC2 REACTOME:50848 KEGG:329 ATLASONC:BIRC2ID795ch11q22 WIKI:BIRC2

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / TNF_RESPONSE  map

References
synonym:cIAP1

BIRC2@Cytoplasm

References
a_re708( Apoptosis  map ):
PMID:15665297
in Hela, cIAP1 is a nuclear protein, that partially translocates to the cytoplasm upon apoptotic stimuli (UV, staurosporin, TRAIL, TNF+CHX), and in a capase-dependent manner
a_re1157:( Apoptosis  map ) reactionType:is.a
a_re1247( Apoptosis  map ):
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:11106668

BIRC2@Nucleus

References
a_re708( Apoptosis  map ):
PMID:15665297
in Hela, cIAP1 is a nuclear protein, that partially translocates to the cytoplasm upon apoptotic stimuli (UV, staurosporin, TRAIL, TNF+CHX), and in a capase-dependent manner
a_re714( Apoptosis  map ):
PMID:18082613
in vitro
in 293T, interaction of endogenous of overexpressed cIAP1 and MAD1
in 293T, a RING mutant of cIAP1 does not induce polyubiquitinylation and degradation of MAD1 as the wt does


Modifications:
In compartment: Cytoplasm
  1. BIRC2@Cytoplasm map

In compartment: Nucleus

  1. BIRC2@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. rBIRC2@Nucleus map map BIRC2@Cytoplasm map

    2. BIRC2@Cytoplasm map map BIRC2@Nucleus map
    3. BIRC2@Cytoplasm map map cIAP*@Cytoplasm map
    4. BIRC2@Cytoplasm map map cleaved~BIRC2*@Cytoplasm map
    5. BIRC2@Nucleus map map BIRC2@Cytoplasm map

    As Catalyser:

    1. MXD1@Nucleus map map MXD1|​ubi@Nucleus map

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