BimEL*

Protein BimEL* map

Identifiers
BCL2-like 11 (apoptosis facilitator)
HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 GENECARDS:BCL2L11 REACTOME:401534 KEGG:10018 ATLASONC:BCL2L11ID772ch2q13 WIKI:BCL2L11
BCL2-like 12 (proline rich)
HUGO:BCL2L12 HGNC:13787 ENTREZ:83596 UNIPROT:Q9HB09 GENECARDS:BCL2L12 ATLASONC:BCL2L12ID773ch19q13 WIKI:BCL2L12

Maps_Modules
 Apoptosis  map  / MOMP_REGULATION  map

References
BCL2L11 splice variant

BimEL*@Cytoplasm

References
a_re436( Apoptosis  map ):
PMID:12646560
in CCL39 chinese hamster lung fibroblast cell line
PMID:15486085
in IL-3 dependent mouse pro-B cell line FL5.12, upon IL-3, ERK dependent phosphorylation of BimEL on S55, S65, S100 (mouse Bim)
in vitro, ERK2 phosphorylates mouse BimEL
in mouse BAF3 cells, in TF-1 human granulocyte macrophage- colony stimulating factor-dependent er ythroleukemia cell line, and in mouse embr yonic fibroblasts when IGF-1 was used as a survival factor, an upshift in BimEL (not BimL) electrophoretic mobility upon IL3. This upshift is lost in FL5.12 if phosphosites are mutated.
PMID:19150432
a_re440:( Apoptosis  map ) reactionType:is.a
a_re442( Apoptosis  map ):
PMID:16282323
in murine BA/F3 IL3-dependent cells, multisite phosphorylation of BimEL upon IL3. Attenuated by ERK and PI3K inhibitors.
in vitro, active mouse Akt purified from IL3 treated BAF3 cells phosphorylates recombinant human BimEL. Blocked by mutation of S87
a_re445:( Apoptosis  map ) PMID:18420585

BimEL*|​S69_pho@Cytoplasm

References
a_re436( Apoptosis  map ):
PMID:12646560
in CCL39 chinese hamster lung fibroblast cell line
PMID:15486085
in IL-3 dependent mouse pro-B cell line FL5.12, upon IL-3, ERK dependent phosphorylation of BimEL on S55, S65, S100 (mouse Bim)
in vitro, ERK2 phosphorylates mouse BimEL
in mouse BAF3 cells, in TF-1 human granulocyte macrophage- colony stimulating factor-dependent er ythroleukemia cell line, and in mouse embr yonic fibroblasts when IGF-1 was used as a survival factor, an upshift in BimEL (not BimL) electrophoretic mobility upon IL3. This upshift is lost in FL5.12 if phosphosites are mutated.
PMID:19150432

BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytoplasm

References
a_re439:( Apoptosis  map ) PMID:19150432

BimEL*|​S87_pho@Cytoplasm

References
a_re442( Apoptosis  map ):
PMID:16282323
in murine BA/F3 IL3-dependent cells, multisite phosphorylation of BimEL upon IL3. Attenuated by ERK and PI3K inhibitors.
in vitro, active mouse Akt purified from IL3 treated BAF3 cells phosphorylates recombinant human BimEL. Blocked by mutation of S87
a_re443( Apoptosis  map ):
in HepG3 cells, insulin activates Akt but not ERK, and induces interaction between 14-3-3 and Bim (IP). In the same cell line, BimEL S87 phosphorylation was not assessed. The authors propose that the 14-3-3 bind to Akt-phosphorylated BimEL

BimEL*|​ubi@Cytoplasm

References
a_re448( Apoptosis  map ):
PMID:19622774
BIM interacts with NDRG1 and with CISH and CUL2 in a NDRG1 dependent manner
NDRG1 expression destabilizes BIM
a_re446:( Apoptosis  map ) PMID:18420585


Modifications:
In compartment: Cytoplasm
  1. BimEL*@Cytoplasm map

  2. BimEL*|​ubi@Cytoplasm map
  3. BimEL*|​S69_pho@Cytoplasm map
  4. BimEL*|​S87_pho@Cytoplasm map
  5. BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. BimEL*:​DYNLL1@Cytoplasm map

  2. 14-3-3*|​unk:​BimEL*|​S87_pho@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytoplasm map map BimEL*|​S69_pho@Cytoplasm map

  2. BimEL*|​S87_pho@Cytoplasm map map BimEL*@Cytoplasm map
  3. BCL2L12@Cytoplasm map map BimEL*|​ubi@Cytoplasm map
  4. BimEL*@Cytoplasm map map BimEL*|​S69_pho@Cytoplasm map
  5. BimEL*|​S69_pho@Cytoplasm map map BimEL*@Cytoplasm map
  6. BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytoplasm map map degraded
  7. BimEL*|​S69_pho@Cytoplasm map map BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytoplasm map
  8. BimEL*@Cytoplasm map map BCL2L11|​ubi@Cytoplasm map
  9. BimEL*@Cytoplasm map map BimEL*|​S87_pho@Cytoplasm map
  10. 14-3-3*|​unk@Cytoplasm map + BimEL*|​S87_pho@Cytoplasm map map 14-3-3*|​unk:​BimEL*|​S87_pho@Cytoplasm map
  11. BimEL*@Cytoplasm map + DYNLL1@Cytoplasm map map BimEL*:​DYNLL1@Cytoplasm map
  12. BimEL*@Cytoplasm map map BimEL*|​ubi@Cytoplasm map
  13. BimEL*|​ubi@Cytoplasm map map BCL2L11|​ubi@Cytoplasm map
  14. BCL2L11|​ubi@Cytoplasm map map BimEL*|​ubi@Cytoplasm map

As Catalyser:

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