BECN1

Protein BECN1 map

Identifiers
beclin 1, autophagy related
HUGO:BECN1 HGNC:1034 ENTREZ:8678 UNIPROT:Q14457 GENECARDS:BECN1 KEGG:8678 ATLASONC:GC_BECN1 WIKI:BECN1

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / APOPTOSIS_GENES  map

BECN1@Cytoplasm

References
a_re410( Apoptosis  map ):
PMID:9765397
PMID:10604474
PMID:16179260
a_re1032( Apoptosis  map ):
PMID:19180116
in HEK293
in vitro
DAPK1 mediated phosphorylation of BECN1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
a_re1034:( Apoptosis  map ) reactionType:is.a
a_re1388:( Apoptosis  map ) PMID:17446862

BECN1|​T119_pho@Cytoplasm

References
a_re1032( Apoptosis  map ):
PMID:19180116
in HEK293
in vitro
DAPK1 mediated phosphorylation of BECN1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
a_re1033:( Apoptosis  map ) reactionType:is.a

BECN1|​T119_unk@Cytoplasm

References
a_re1033:( Apoptosis  map ) reactionType:is.a
a_re375( Apoptosis  map ):
PMID:15146184
inhibition relieved in mouse model of Huntington disease, where mTOR is inhibited by sequestration into polyglutamine aggregates
PMID:16839881
p53 target gene DRAM1 is necessary for induction of autophagy
PMID:20424262
by ammonia
a_re651( Apoptosis  map ):
in vitro by CASP3, CASP7, CASP8
in Ba/F3 upon IL3 deprivation, in FDCP1 upon IL3 deprivation, in U937 upon serum starvation, z-VAD-fmk inhibitable cleavage
in Ba/F3 upon doxorubicin or etoposide or anti-Fas


Modifications:
In compartment: Cytoplasm
  1. BECN1@Cytoplasm map

  2. BECN1|​T119_pho@Cytoplasm map
  3. BECN1|​T119_unk@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. BCL2:​BECN1@Cytoplasm map

  2. BCL2-XL*:​BECN1@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. BECN1@Cytoplasm map map BECN1|​T119_pho@Cytoplasm map

  2. BECN1|​T119_pho@Cytoplasm map map BECN1|​T119_unk@Cytoplasm map
  3. BECN1@Cytoplasm map map BECN1|​T119_unk@Cytoplasm map
  4. BCL2-XL*@Cytoplasm map + BECN1@Cytoplasm map map BCL2-XL*:​BECN1@Cytoplasm map
  5. rBECN1@Nucleus map map BECN1@Cytoplasm map
  6. BECN1@Cytoplasm map + BCL2@Cytoplasm map map BCL2:​BECN1@Cytoplasm map
  7. BECN1|​T119_unk@Cytoplasm map map cleaved~BECN1*@Cytoplasm map

As Catalyser:

  1. degraded map Autophagy@Cytoplasm map

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