BCL9:DVL*:JUN:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*:p300*

Complex BCL9:DVL*:JUN:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*:p300* map


Complex composition:

  1. LEF_TCF* map
  2. WRE* map
  3. BCL9 map
  4. PYGO* map
  5. p300* map
  6. _beta_-Catenin* map
  7. DVL* map
  8. JUN map




BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus

Identifiers
NAME:BCL9:DVL*:JUN:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*:p300*

References
s_wca3_re6( Survival  map ):
PMID:16169192
B-catenin competes with TLE for Lef-1
PMID:15768032
CBP-and P300-mediated transcription different cell fates
PMID:20530697
(phosphorylated) C-JUN can bind to TCF4
PMID:18347071 PMID:16007074
s_wca3_re7( Survival  map ):
The transcription complex containing P300 initiates transcription of genes that are involved in differentiation.
PMID:20920541
The repressor complex is is by default present on the enhancers of wnt-target genes
PMID:16510874
s_wca3_re65( Survival  map ):
PMID:22761862
Smad1 alone inhibits myc expression while b-catenin/TCF4 activates gene expression. Highest gene expression obtained when SMAD1/b-catenin/TCF4 complex is formed
PMID:15576399
Mi-2/NuRD
PMID:22290435
s_wca3_re154( Survival  map ):
SOX9
PMID:23306204
p300 transcription complex
PMID:15806138
WNT-target gene:
PMID:20122174
s_wca3_re155( Survival  map ):
Transcription complex containing b-catenin and P300
PMID:17050667 PMID:21767405
RAD6B is overexpressed in breast cancer
PMID:11929833
RAD6B upregulated in invasive breast cancer
PMID:22705350
s_wca3_re157( Survival  map ):
BCL9 is a target gene of the wnt pathway.
PMID:18627596
However not known which transcription complex is involved either with CBP or P300. I have chosen this complex randomly
s_wca3_re166( Survival  map ):
Not known if P300 transcription complex mediates this trancription either it is CBP transcription complex
PMID:17291450

Confidence
REF=5 FUNC=3


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. APC|​T1487_pho:​CTBP*|​hm2:​HDAC1_2*@Nucleus map + BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map

  2. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map + BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map + HDAC1_2*:​TLE*|​ubi@Nucleus map

As Catalyser:

  1. gTCF4@Nucleus map map rTCF4@Nucleus map

  2. gRAD6B*@Nucleus map map rRAD6B*@Nucleus map
  3. gBCL9@Nucleus map map rBCL9@Nucleus map
  4. gCRIPTO-1*@Nucleus map map rCRIPTO-1*@Nucleus map
  5. gMYC@Nucleus map map rMYC@Nucleus map
  6. gGene under control of_br_ P300-mediated transcription*@Nucleus map map rRNA@Nucleus map

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