BCL2:p53*

Complex BCL2:p53* map


Complex composition:

  1. BCL2 map
  2. p53* map




BCL2:​p53*@Mitochondrial outer membrane

Identifiers
NAME:BCL2:p53*

References
a_re1406( Apoptosis  map ):
PMID:18845789
unphosphorylated TP53 from coIP experiments with okadaic acid (PKC inhibitor) or ceramide C2 (potent inductor of PP1/2A

Confidence
REF=1 FUNC=5

BCL2:​p53*@Mitochondria

Identifiers
NAME:BCL2:p53*

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:12667443
Fraction of induced p53 translocates to the mitochondria of apoptosing tumor cells. Targeting p53 to mitochondria is sufficient to launch apoptosis.
p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BCL2L1 and BCL2 proteins, resulting in cytochrome c release.
PMID:14963330
In other hand, cytosolic localization of endogenous p53 was necessary and sufficient for apoptosis. p53 directly activated the pro-apoptotic BCL2 protein Bax in the absence of other proteins to permeabilize mitochondria and engage the apoptotic program.
Binding of BCL2 or BCL2L1 to TP53 therefore antagonizes the activation of BAX via binding to TP53. Like this BCL2 and BCL2L1 also perform their anti-apoptotic effect.
e_re433( EMT  map ):
p53 induces apoptosis by target gene regulation and transcription-independent signaling.
A fraction of induced p53 translocates to the mitochondria of apoptosing tumor cells. Targeting p53 to mitochondria is sufficient to launch apoptosis.
Evidence that p53 translocation to the mitochondria occurs in vivo in irradiatedthymocytes was shown.

Confidence
REF=2 FUNC=5


Modifications:
Participates in complexes:
In compartment: Mitochondria
  1. BCL2:​p53*@Mitochondria map

In compartment: Mitochondrial outer membrane

  1. BCL2:​p53*@Mitochondrial outer membrane map

Participates in reactions:
As Reactant or Product:

  1. BCL2|​unk@Mitochondrial outer membrane map + p53*|​S15_unk@Cytoplasm map map BCL2:​p53*@Mitochondrial outer membrane map

  2. p53*@Mitochondria map + BCL2@Mitochondria map map BCL2:​p53*@Mitochondria map

As Catalyser:

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