BCL2-XL*

Protein BCL2-XL* map

Identifiers
BCL2-like 1
HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1
BCL2-like 1BCL2-associated agonist of cell death

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / MOMP_REGULATION  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:12667443
PMID:22039431
The Bcl2 family proteins regulate and mediate the mitochondrial outer membrane permeabilization, a crucial event in the mitochondrial pathway of apoptosis in vertebrates.
The regulation of apoptosis is governed largely by interactions between the pro-survival and pro-death members of the Bcl2 protein family.
Some members of this family (e.g., Bax, Bak, and Bid: pro-apoptotic proteins) promote apoptosis, while others such as BCL2, BCL2L1, BCL2L2 (anti-apoptotic proteins) work against programmed cell death.
The BCL2 family proteins are characterized by regions of specific sequence homology named as BCL2 homology (BH) motifs that number from 1 to 4 and are critical for function.
Especially a helical BH3 motif of pro-apoptotic proteins occupy and form strong interactions with hydrophobic groove of anti-apoptotic BCL2 family proteins which leads to the activation of the essential death mediators Bax and Bak, thereby committing cells to apoptosis
PMID:22836101
BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cells.
The activation of the pro-death family member BAX is often the final step before cell death in neurons.
Pro-survival family members such as BCL2L1 act to inhibit BAX activation
PMID:23064052
PMID:11085534
BCL2 and BCL2L1 are known to be overexpressed in several cancers.
In particular, BCL2L1 overexpression has been correlated with cancer cells resistance to chemotherapeutic agents
synonym:BCL2-XL
PMID:10949026
PMID:18097445

BCL2-XL*@Mitochondria

References
e_re425( EMT  map ):
PMID:11463392
BBC3 (so-called PUMA, p53 upregulated modulator of apoptosis) as a target for activation by p53.
This gene encodes two BH3 domain–containing proteins that are induced in cells following p53 activation.
BBC3 binds to BCL2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of programmed cell death.
Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role inmediating p53-induced cell death through the cytochrome c/Apaf-1–dependent pathway.
PMID:11463391
PUMA was found to be exclusively mitochondrial and to bind to BCL2 and BCL2L1 through a BH3 domain.
e_re426( EMT  map ):
PMID:12667443
p53 induces apoptosis by target gene regulation and transcription-independent signaling.
A fraction of induced p53 translocates to the mitochondria of apoptosing tumor cells. Targeting p53 to mitochondria is sufficient to launch apoptosis.
Evidence that p53 translocation to the mitochondria occurs in vivo in irradiatedthymocytes was shown.
Further, p53 can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BCL2L1, resulting in cytochrome c release.
p53 binds to BCL2L1 via its DNA binding domain.
Tumor-derived transactivation-deficient mutants of p53 concomitantly lose the ability to interact with BCL2L1 and promote cytochrome c release.
e_re429( EMT  map ):
PMID:22039431
The Bcl2 family proteins regulate and mediate the mitochondrial outer membrane permeabilization, a crucial event in the mitochondrial pathway of apoptosis in vertebrates.
The regulation of apoptosis is governed largely by interactions between the pro-survival and pro-death members of the Bcl2 protein family.
Some members of this family (e.g., Bax, Bak, and Bid: pro-apoptotic protines) promote apoptosis, while others such as BCL2, BCL2L1, BCL2L2 (anti-apoptotic protines)work against programmed cell death.
The BCL2 family proteins are characterized by regions of specific sequence homology named as BCL2 homology (BH) motifs that number from 1 to 4 and are critical for function.
Especially a helical BH3 motif of pro-apoptotic proteins occupy and form strong interactions with hydrophobic groove of anti-apoptotic BCL2 family proteins which leads to the activation of the essential death mediators Bax and Bak, thereby committing cells to apoptosis
PMID:22836101
BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cells.
The activation of the pro-death family member BAX is often the final step before cell death in neurons.
Pro-survival family members such as BCL2L1 act to inhibit BAX activation
e_re432( EMT  map ):

BCL2-XL*@Cytoplasm

References
a_re1388:( Apoptosis  map ) PMID:17446862

BCL2-XL*@Mitochondrial outer membrane

References
a_re583( Apoptosis  map ):
PMID:15724238
in human tonsil B cells, constitutive interaction
PMID:9430630
a_re593:( Apoptosis  map ) PMID:16608847
a_re603( Apoptosis  map ):
PMID:11546872
in HEK293T, coIP
Y2H
a_re606( Apoptosis  map ):
PMID:9130713
PMID:10075695
in 293T, IP
a_re1003:( Apoptosis  map ) PMID:9660918
a_re1131:( Apoptosis  map ) PMID:12011449
a_re1246( Apoptosis  map ):
influenceDelete: reactants to re
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:9435230


Modifications:
In compartment: Cytoplasm
  1. BCL2-XL*@Cytoplasm map

In compartment: Mitochondria

  1. BCL2-XL*@Mitochondria map

In compartment: Mitochondrial outer membrane

  1. BCL2-XL*@Mitochondrial outer membrane map

Participates in complexes:
In compartment: Cytoplasm

  1. BCL2-XL*:​BECN1@Cytoplasm map

In compartment: Mitochondria

  1. BAX:​BCL2-XL*@Mitochondria map

  2. BAK1:​BCL2-XL*@Mitochondria map
  3. BBC3:​BCL2-XL*@Mitochondria map
  4. BCL2-XL*:​p53*@Mitochondria map

In compartment: Mitochondrial outer membrane

  1. BCL2-XL*:​HRK@Mitochondrial outer membrane map

  2. BBC3:​BCL2-XL*@Mitochondrial outer membrane map
  3. BCL2-XL*:​p53*@Mitochondrial outer membrane map
  4. BCL2-XL*:​SIVA1@Mitochondrial outer membrane map
  5. BCL2-XL*:​TMBIM6@Mitochondrial outer membrane map
  6. BCL2-XL*:​BCL2L11@Mitochondrial outer membrane map
  7. BCL2-XL*:​BMF|​unk@Mitochondrial outer membrane map
  8. BAD|​S91_unk:​BCL2-XL*@Mitochondrial outer membrane map
  9. BCL2-XL*:​cleaved_BID*|​myr@Mitochondrial outer membrane map
  10. BAX|​S163_unk|​T167_unk:​BCL2-XL*@Mitochondrial outer membrane map

Participates in reactions:
As Reactant or Product:

  1. TMBIM6@Mitochondrial outer membrane map + BCL2-XL*@Mitochondrial outer membrane map map BCL2-XL*:​TMBIM6@Mitochondrial outer membrane map

  2. SIVA1@Cytoplasm map + BCL2-XL*@Mitochondrial outer membrane map map BCL2-XL*:​SIVA1@Mitochondrial outer membrane map
  3. BCL2-XL*@Mitochondrial outer membrane map map cleaved~BCL2_XL*@Mitochondrial outer membrane map
  4. BCL2-XL*@Cytoplasm map + BECN1@Cytoplasm map map BCL2-XL*:​BECN1@Cytoplasm map
  5. BCL2-XL*@Mitochondrial outer membrane map + BAX|​S163_unk|​T167_unk@Mitochondrial outer membrane map map BAX|​S163_unk|​T167_unk:​BCL2-XL*@Mitochondrial outer membrane map
  6. BCL2-XL*@Mitochondrial outer membrane map + p53*|​S15_unk@Cytoplasm map map BCL2-XL*:​p53*@Mitochondrial outer membrane map
  7. rBCL2-XL*@Nucleus map map BCL2-XL*@Cytoplasm map
  8. BCL2L11@Mitochondrial outer membrane map + BCL2-XL*@Mitochondrial outer membrane map map BCL2-XL*:​BCL2L11@Mitochondrial outer membrane map
  9. cleaved_BID*|​myr@Mitochondrial outer membrane map + BCL2-XL*@Mitochondrial outer membrane map map BCL2-XL*:​cleaved_BID*|​myr@Mitochondrial outer membrane map
  10. BBC3@Mitochondrial outer membrane map + BCL2-XL*@Mitochondrial outer membrane map map BBC3:​BCL2-XL*@Mitochondrial outer membrane map
  11. BAD|​S91_unk|​active@Cytoplasm map + BCL2-XL*@Mitochondrial outer membrane map map BAD|​S91_unk:​BCL2-XL*@Mitochondrial outer membrane map
  12. BMF|​unk@Mitochondrial outer membrane map + BCL2-XL*@Mitochondrial outer membrane map map BCL2-XL*:​BMF|​unk@Mitochondrial outer membrane map
  13. HRK@Mitochondrial outer membrane map + BCL2-XL*@Mitochondrial outer membrane map map BCL2-XL*:​HRK@Mitochondrial outer membrane map
  14. BAD_binding partners*@Mitochondria map map BCL2-XL*@Mitochondria map
  15. BBC3@Mitochondria map + BCL2-XL*@Mitochondria map map BBC3:​BCL2-XL*@Mitochondria map
  16. BCL2-XL*@Mitochondria map + p53*@Mitochondria map map BCL2-XL*:​p53*@Mitochondria map
  17. BCL2-XL*@Mitochondria map + BAX@Cytoplasm map map BAX:​BCL2-XL*@Mitochondria map
  18. BCL2-XL*@Mitochondria map + BAK1@Mitochondria map map BAK1:​BCL2-XL*@Mitochondria map
  19. 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map map 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map + BCL2-XL*@Mitochondria map
  20. BCL2-XL*@Mitochondria map map Prosurvival@Mitochondria map
  21. BAX@Cytoplasm map + BCL2-XL*@Cytoplasm map map BAX:​BCL2-XL*@Mitochondria map
  22. BAX:​BCL2-XL*@Mitochondria map + BAX_sub_TRUNC_endsub_*@Cytoplasm map map s_s_wnc2_s64 + BAX@Cytoplasm map

As Catalyser:

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