BCAR1:FAK1*:PXN:Talin*:Vinculin*:c-SRC*

Complex BCAR1:FAK1*:PXN:Talin*:Vinculin*:c-SRC* map


Complex composition:

  1. c-SRC* map
  2. Talin* map
  3. PXN map
  4. Vinculin* map
  5. FAK1* map
  6. BCAR1 map




BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm

Identifiers
NAME:BCAR1:FAK1*:PXN:Talin*:Vinculin*:c-SRC*

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map

References
PMID:15688067
The integrin-binding protein talin recruits FAK1 and vinculin to focal contacts.
e_re987( EMT  map ):
Alpha-actinin servers a link between cytoskeletal actin (in stress fibres) and vinculin at the focal contacts.
Phosphorylation of alpha-actinin by FAK1 (PTK2) redues this ability of linking actin to vinculin, thus prevents the maturation of focal contacts.

Confidence
REF=0 FUNC=4


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. FAK1*|​Y_pho|​pho:​c-SRC*@Cytoplasm map + BCAR1@Cytoplasm map + Talin*@Cytoplasm map + PXN|​pho@Cytoplasm map + Vinculin*@Cytoplasm map map BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map

  2. BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map + Actinin*@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map

As Catalyser:

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