BBC3:BCL2

Complex BBC3:BCL2 map


Complex composition:

  1. BCL2 map
  2. BBC3 map




BBC3:​BCL2@Mitochondrial outer membrane

Identifiers
NAME:BBC3:BCL2

Confidence
REF=0 FUNC=5

BBC3:​BCL2@Mitochondria

Identifiers
NAME:BBC3:BCL2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:11463392
BBC3 (so-called PUMA, p53 upregulated modulator of apoptosis) as a target for activation by p53.
This gene encodes two BH3 domain–containing proteins that are induced in cells following p53 activation.
BBC3 binds to BCL2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of programmed cell death.
Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role inmediating p53-induced cell death through the cytochrome c/Apaf-1–dependent pathway.
PMID:11463391
PUMA was found to be exclusively mitochondrial and to bind to BCL2 and BCL2L1 through a BH3 domain.
It is via this binding to BBC3 (an apoptic inducer) that BCL2 and BCL2L1 exhibit their anti-apoptic effect.

Confidence
REF=2 FUNC=5


Modifications:
Participates in complexes:
In compartment: Mitochondria
  1. BBC3:​BCL2@Mitochondria map

In compartment: Mitochondrial outer membrane

  1. BBC3:​BCL2@Mitochondrial outer membrane map

Participates in reactions:
As Reactant or Product:

  1. BBC3@Mitochondrial outer membrane map + BCL2|​pho@Mitochondrial outer membrane map map BBC3:​BCL2@Mitochondrial outer membrane map

  2. BBC3@Mitochondria map + BCL2@Mitochondria map map BBC3:​BCL2@Mitochondria map

As Catalyser:

    48 thoughts on “BBC3:BCL2

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