Complex BBC3:BCL2 map

Complex composition:

  1. BCL2 map
  2. BBC3 map

BBC3:​BCL2@Mitochondrial outer membrane





 EMT  map  / EMT_REGULATORS  map

BBC3 (so-called PUMA, p53 upregulated modulator of apoptosis) as a target for activation by p53.
This gene encodes two BH3 domain–containing proteins that are induced in cells following p53 activation.
BBC3 binds to BCL2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of programmed cell death.
Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role inmediating p53-induced cell death through the cytochrome c/Apaf-1–dependent pathway.
PUMA was found to be exclusively mitochondrial and to bind to BCL2 and BCL2L1 through a BH3 domain.
It is via this binding to BBC3 (an apoptic inducer) that BCL2 and BCL2L1 exhibit their anti-apoptic effect.


Participates in complexes:
In compartment: Mitochondria
  1. BBC3:​BCL2@Mitochondria map

In compartment: Mitochondrial outer membrane

  1. BBC3:​BCL2@Mitochondrial outer membrane map

Participates in reactions:
As Reactant or Product:

  1. BBC3@Mitochondrial outer membrane map + BCL2|​pho@Mitochondrial outer membrane map map BBC3:​BCL2@Mitochondrial outer membrane map

  2. BBC3@Mitochondria map + BCL2@Mitochondria map map BBC3:​BCL2@Mitochondria map

As Catalyser:

    48 thoughts on “BBC3:BCL2

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