BBC3

Protein BBC3 map

Identifiers
BCL2 binding component 3
HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 GENECARDS:BBC3 KEGG:27113 ATLASONC:BBC3ID759ch19q13 WIKI:BBC3

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / MOMP_REGULATION  map

References
PMID:11463392
BBC3 (so-called PUMA, p53 upregulated modulator of apoptosis) as a target for activation by p53.
This gene encodes two BH3 domain–containing proteins that are induced in cells following p53 activation.
BBC3 binds to BCL2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of programmed cell death.
Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role inmediating p53-induced cell death through the cytochrome c/Apaf-1–dependent pathway.
PMID:11463391
PUMA was found to be exclusively mitochondrial and to bind to BCL2 and BCL2L1 through a BH3 domain.
synonym:PUMA

BBC3@Mitochondria

References
e_re425( EMT  map ):
PMID:11463392
BBC3 (so-called PUMA, p53 upregulated modulator of apoptosis) as a target for activation by p53.
This gene encodes two BH3 domain–containing proteins that are induced in cells following p53 activation.
BBC3 binds to BCL2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of programmed cell death.
Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role inmediating p53-induced cell death through the cytochrome c/Apaf-1–dependent pathway.
PMID:11463391
PUMA was found to be exclusively mitochondrial and to bind to BCL2 and BCL2L1 through a BH3 domain.
e_re428( EMT  map ):
PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells
It is via this binding to BBC3 (an apoptic inducer) that BCL2L1 exhibits its anti-apoptotic effect.
e_re436( EMT  map ):
It is via this binding to BBC3 (an apoptic inducer) that BCL2 and BCL2L1 exhibit their anti-apoptic effect.

BBC3@Mitochondrial outer membrane

References
a_re593:( Apoptosis  map ) PMID:16608847


Modifications:
In compartment: Cytoplasm
  1. BBC3@Cytoplasm map

In compartment: Mitochondria

  1. BBC3@Mitochondria map

In compartment: Mitochondrial outer membrane

  1. BBC3@Mitochondrial outer membrane map

Participates in complexes:
In compartment: Mitochondria

  1. BBC3:​BCL2@Mitochondria map

  2. BBC3:​BCL2-XL*@Mitochondria map

In compartment: Mitochondrial outer membrane

  1. BBC3:​BCL2@Mitochondrial outer membrane map

  2. BBC3:​BCL2A1@Mitochondrial outer membrane map
  3. BBC3:​BCL2L2@Mitochondrial outer membrane map
  4. BBC3:​BCL2-XL*@Mitochondrial outer membrane map
  5. BBC3:​MCL1|​S159_unk@Mitochondrial outer membrane map

Participates in reactions:
As Reactant or Product:

  1. rBBC3@Nucleus map map BBC3@Cytoplasm map

  2. BBC3@Mitochondrial outer membrane map + BCL2|​pho@Mitochondrial outer membrane map map BBC3:​BCL2@Mitochondrial outer membrane map
  3. BBC3@Mitochondrial outer membrane map + BCL2-XL*@Mitochondrial outer membrane map map BBC3:​BCL2-XL*@Mitochondrial outer membrane map
  4. BBC3@Mitochondrial outer membrane map + BCL2L2@Mitochondrial outer membrane map map BBC3:​BCL2L2@Mitochondrial outer membrane map
  5. BBC3@Mitochondrial outer membrane map + BCL2A1@Mitochondrial outer membrane map map BBC3:​BCL2A1@Mitochondrial outer membrane map
  6. BBC3@Mitochondrial outer membrane map + MCL1|​S159_unk@Mitochondrial outer membrane map map BBC3:​MCL1|​S159_unk@Mitochondrial outer membrane map
  7. BBC3@Mitochondria map + BCL2-XL*@Mitochondria map map BBC3:​BCL2-XL*@Mitochondria map
  8. BBC3@Mitochondria map map Apoptosis@Cytoplasm map
  9. BBC3@Mitochondria map + BCL2@Mitochondria map map BBC3:​BCL2@Mitochondria map

As Catalyser:

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