Cytosolic localization of endogenous p53 was necessary and sufficient for apoptosis.
p53 directly activated the pro-apoptotic BCL2 protein Bax in the absence of other proteins to permeabilize mitochondria and engage the apoptotic program.
It was proposed that when p53 accumulates in the cytosol, it can function analogously to the pro-apoptotic BAX protein to activate Bax and trigger apoptosis.
Participates in complexes:
In compartment: Cytoplasm
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As Reactant or Product: