BAX:p53*

Complex BAX:p53* map


Complex composition:

  1. p53* map
  2. BAX map




BAX:​p53*@Cytoplasm

Identifiers
NAME:BAX:p53*

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:14963330
Cytosolic localization of endogenous p53 was necessary and sufficient for apoptosis.
p53 directly activated the pro-apoptotic BCL2 protein Bax in the absence of other proteins to permeabilize mitochondria and engage the apoptotic program.
It was proposed that when p53 accumulates in the cytosol, it can function analogously to the pro-apoptotic BAX protein to activate Bax and trigger apoptosis.

Confidence
REF=1 FUNC=4


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. BAX:​p53*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. p53*@Mitochondria map + BAX@Cytoplasm map map BAX:​p53*@Cytoplasm map

  2. BAX:​p53*@Cytoplasm map map Apoptosis@Cytoplasm map

As Catalyser:

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