BAK1:p53*

Complex BAK1:p53* map


Complex composition:

  1. BAK1 map
  2. p53* map




BAK1:​p53*@Mitochondria

Identifiers
NAME:BAK1:p53*

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:15077116
p53 has a direct signalling role at mitochondria in the induction of apoptosis
p53 interacts with the pro- apoptotic mitochondrial membrane protein Bak. Interaction of p53 with Bak causes oligomerization and thus activation of Bak and release of cytochrome c from mitochondria.
Formation of the p53–Bak complex coincides with loss of an interaction between Bak and the anti-apoptotic Bcl2-family member Mcl1.
These results are consistent with a model in which p53 and Mcl1 have opposing effects on mitochondrial apoptosis by interacting with, and modulating the activity of, the death effector Bak.

Confidence
REF=1 FUNC=5


Modifications:
Participates in complexes:
In compartment: Mitochondria
  1. BAK1:​p53*@Mitochondria map

Participates in reactions:
As Reactant or Product:

  1. p53*@Mitochondria map + BAK1@Mitochondria map map BAK1:​p53*@Mitochondria map

  2. BAK1:​p53*@Mitochondria map map Apoptosis@Cytoplasm map

As Catalyser:

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