p53 has a direct signalling role at mitochondria in the induction of apoptosis
p53 interacts with the pro- apoptotic mitochondrial membrane protein Bak. Interaction of p53 with Bak causes oligomerization and thus activation of Bak and release of cytochrome c from mitochondria.
Formation of the p53–Bak complex coincides with loss of an interaction between Bak and the anti-apoptotic Bcl2-family member Mcl1.
These results are consistent with a model in which p53 and Mcl1 have opposing effects on mitochondrial apoptosis by interacting with, and modulating the activity of, the death effector Bak.
Participates in complexes:
In compartment: Mitochondria
Participates in reactions:
As Reactant or Product:
- p53*@Mitochondria + BAK1@Mitochondria → BAK1:p53*@Mitochondria
- BAK1:p53*@Mitochondria → Apoptosis@Cytoplasm