BAK1:BCL2-XL*

Complex BAK1:BCL2-XL* map


Complex composition:

  1. BAK1 map
  2. BCL2-XL* map




BAK1:​BCL2-XL*@Mitochondria

Identifiers
NAME:BAK1:BCL2-XL*

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
e_re432( EMT  map ):
PMID:22039431
The Bcl2 family proteins regulate and mediate the mitochondrial outer membrane permeabilization, a crucial event in the mitochondrial pathway of apoptosis in vertebrates.
The regulation of apoptosis is governed largely by interactions between the pro-survival and pro-death members of the Bcl2 protein family.
Some members of this family (e.g., Bax, Bak, and Bid: pro-apoptotic protines) promote apoptosis, while others such as BCL2, BCL2L1, BCL2L2 (anti-apoptotic protines)work against programmed cell death.
The BCL2 family proteins are characterized by regions of specific sequence homology named as BCL2 homology (BH) motifs that number from 1 to 4 and are critical for function.
Especially a helical BH3 motif of pro-apoptotic proteins occupy and form strong interactions with hydrophobic groove of anti-apoptotic BCL2 family proteins which leads to the activation of the essential death mediators Bax and Bak, thereby committing cells to apoptosis:

Confidence
REF=1 FUNC=5


Modifications:
Participates in complexes:
In compartment: Mitochondria
  1. BAK1:​BCL2-XL*@Mitochondria map

Participates in reactions:
As Reactant or Product:

  1. BCL2-XL*@Mitochondria map + BAK1@Mitochondria map map BAK1:​BCL2-XL*@Mitochondria map

As Catalyser:

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