BAK1

Protein BAK1 map

Identifiers
BCL2-antagonist/killer 1
HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 GENECARDS:BAK1 REACTOME:50691 KEGG:578 ATLASONC:BAK1ID752ch6p21 WIKI:BAK1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / MOMP_REGULATION  map

References
PMID:22039431
The Bcl2 family proteins regulate and mediate the mitochondrial outer membrane permeabilization, a crucial event in the mitochondrial pathway of apoptosis in vertebrates.
The regulation of apoptosis is governed largely by interactions between the pro-survival and pro-death members of the Bcl2 protein family.
Some members of this family (e.g., Bax, Bak, and Bid: pro-apoptotic proteins) promote apoptosis, while others such as BCL2, BCL2L1, BCL2L2 (anti-apoptotic proteins) work against programmed cell death.
The BCL2 family proteins are characterized by regions of specific sequence homology named as BCL2 homology (BH) motifs that number from 1 to 4 and are critical for function.
Especially a helical BH3 motif of pro-apoptotic proteins occupy and form strong interactions with hydrophobic groove of anti-apoptotic BCL2 family proteins which leads to the activation of the essential death mediators Bax and Bak, thereby committing cells to apoptosis

BAK1@Mitochondria

References
e_re431( EMT  map ):
PMID:22039431
The Bcl2 family proteins regulate and mediate the mitochondrial outer membrane permeabilization, a crucial event in the mitochondrial pathway of apoptosis in vertebrates.
The regulation of apoptosis is governed largely by interactions between the pro-survival and pro-death members of the Bcl2 protein family.
Some members of this family (e.g., Bax, Bak, and Bid: pro-apoptotic protines) promote apoptosis, while others such as BCL2, BCL2L1, BCL2L2 (anti-apoptotic protines)work against programmed cell death.
The BCL2 family proteins are characterized by regions of specific sequence homology named as BCL2 homology (BH) motifs that number from 1 to 4 and are critical for function.
Especially a helical BH3 motif of pro-apoptotic proteins occupy and form strong interactions with hydrophobic groove of anti-apoptotic BCL2 family proteins which leads to the activation of the essential death mediators Bax and Bak, thereby committing cells to apoptosis:
e_re437( EMT  map ):
PMID:15077116
p53 has a direct signalling role at mitochondria in the induction of apoptosis
p53 interacts with the pro- apoptotic mitochondrial membrane protein Bak. Interaction of p53 with Bak causes oligomerization and thus activation of Bak and release of cytochrome c from mitochondria.
Formation of the p53–Bak complex coincides with loss of an interaction between Bak and the anti-apoptotic Bcl2-family member Mcl1.
These results are consistent with a model in which p53 and Mcl1 have opposing effects on mitochondrial apoptosis by interacting with, and modulating the activity of, the death effector Bak.

BAK1@Mitochondrial outer membrane

References
a_re11( Apoptosis  map ):
PMID:10950869
direct activation of BAK by tBID
a_re1262( Apoptosis  map ):
PMID:20460378
in breast cancer cell lines MDA-435, MDA-231, MCF7 and SKBr3
a_re8( Apoptosis  map ):
in Ba/F3 cells, stable expression of the C-terminal cleavage product of BECN1 sensitizes cells to IL3-deprivation induced apoptosis
in vitro, incubation of isolated mitochondria with recombinant BECN1 C-terminal cleavage product triggers release of Omi/HtrA2 and cytochrome c
PMID:11832478
in vitro CASP2 unlike CASP8 induce release of CYCS , DIABLO and AIF form purified mitochondria from Hela cells
a_re12( Apoptosis  map ):
PMID:12881569
PMID:19706873
a_re13( Apoptosis  map ):
PMID:18056423
in mouse liver
a_re1417( Apoptosis  map ):
PMID:20501829
in DU-145 upon ER stress induced by IL24 ectopic expression


Modifications:
In compartment: Mitochondria
  1. BAK1@Mitochondria map

In compartment: Mitochondrial outer membrane

  1. BAK1@Mitochondrial outer membrane map

Participates in complexes:
In compartment: Mitochondria

  1. BAK1:​BCL2@Mitochondria map

  2. BAK1:​p53*@Mitochondria map
  3. BAK1:​BCL2-XL*@Mitochondria map

In compartment: Mitochondrial outer membrane

  1. BAK1:​VDAC2@Mitochondrial outer membrane map

  2. BAK1:​IGFBP1@Mitochondrial outer membrane map
  3. BAK1:​MCL1|​S159_unk@Mitochondrial outer membrane map

Participates in reactions:
As Reactant or Product:

  1. BAK1@Mitochondrial outer membrane map map a_s11

  2. VDAC2@Mitochondrial outer membrane map + BAK1@Mitochondrial outer membrane map map BAK1:​VDAC2@Mitochondrial outer membrane map
  3. rBAK1@Nucleus map map BAK1@Mitochondrial outer membrane map
  4. BAK1@Mitochondrial outer membrane map + IGFBP1@Cytoplasm map map BAK1:​IGFBP1@Mitochondrial outer membrane map
  5. MCL1|​S159_unk@Mitochondrial outer membrane map + BAK1@Mitochondrial outer membrane map map BAK1:​MCL1|​S159_unk@Mitochondrial outer membrane map
  6. BCL2@Mitochondria map + BAK1@Mitochondria map map BAK1:​BCL2@Mitochondria map
  7. BCL2-XL*@Mitochondria map + BAK1@Mitochondria map map BAK1:​BCL2-XL*@Mitochondria map
  8. p53*@Mitochondria map + BAK1@Mitochondria map map BAK1:​p53*@Mitochondria map
  9. BAK1:​p53*@Mitochondria map map Apoptosis@Cytoplasm map

As Catalyser:

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