BAD:BCL2

Complex BAD:BCL2 map


Complex composition:

  1. BAD map
  2. BCL2 map




BAD|​S91_unk:​BCL2@Mitochondrial outer membrane

Identifiers
NAME:BAD:BCL2

References
a_re597:( Apoptosis  map ) testtest
a_re1420( Apoptosis  map ):
PMID:8929532
in vitro RAF1:BCL2 interaction
in 293, overexpression of BCL2 induces relocalization of RAF1-GFP to mitochondria
in vitro phosphorylation of BAD by RAF1
in 293T, over-expression of a mitochondria-targeted version of RAF1 induces phosphorylation of BAD (controls: plasma membrane targeted RAF1, kinase dead mutant)
BCL2 over-expression targets RAF1 kinase domain-GFP to mitochondria
mitochondria-targeted RAF1 (deleted for Ras binding domain) potentiates BCL2 anti-apoptotic activity in 32D.3 exposed to staurosporine or upon IL-3 withdrawal

Confidence
REF=1 FUNC=5


Modifications:
Participates in complexes:
In compartment: Mitochondrial outer membrane
  1. BAD|​S91_unk:​BCL2@Mitochondrial outer membrane map

Participates in reactions:
As Reactant or Product:

  1. BAD|​S91_unk:​BCL2@Mitochondrial outer membrane map map BCL2@Mitochondrial outer membrane map + BAD|​pho@Cytoplasm map

  2. BAD|​S91_unk|​active@Cytoplasm map + BCL2|​pho@Mitochondrial outer membrane map map BAD|​S91_unk:​BCL2@Mitochondrial outer membrane map

As Catalyser:

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